Latanoprost and Physostigmine Have Mostly Additive Ocular Hypotensive Effects in Human Eyes

Use of latanoprost to reduce acute intraocular pressure rise following neodymium: Yag laser iridotomy

“…Pressure spikes after LI occur most frequently within the first 2 hours (Robin & Pollack 1984), while the IOP‐lowering effect of latanoprost reaches its peak 8–12 hours after administration (Villumsen & Alm 1992; Watson et al. 1996; Lindén & Alm 1997). In the present study, latanoprost was instilled 90 min before LI for reasons of practice feasibility so that patients did not have to spend a long time waiting in hospital.…”

“…Clinical study, however, shows a partially additive hypotensive effect when PGF 2 α is combined with pilocarpine (Friström & Nilsson 1993). Furthermore, Lindén & Alm (1997) demonstrated that administration of a strong cholinergic agent, physostigmine salicylate 8 mg/mL, every 2 hours could neither maintain a sustained contraction of the ciliary muscle nor abolish the hypotensive effect of latanoprost in healthy volunteers. The authors believe that pretreatment with a cholinergic agonist should not prevent latanoprost from reaching the FP receptors in human ciliary muscles.…”

Use of latanoprost to reduce acute intraocular pressure rise following neodymium: Yag laser iridotomy

“…Pressure spikes after LI occur most frequently within the first 2 hours (Robin & Pollack 1984), while the IOP‐lowering effect of latanoprost reaches its peak 8–12 hours after administration (Villumsen & Alm 1992; Watson et al. 1996; Lindén & Alm 1997). In the present study, latanoprost was instilled 90 min before LI for reasons of practice feasibility so that patients did not have to spend a long time waiting in hospital.…”

“…Clinical study, however, shows a partially additive hypotensive effect when PGF 2 α is combined with pilocarpine (Friström & Nilsson 1993). Furthermore, Lindén & Alm (1997) demonstrated that administration of a strong cholinergic agent, physostigmine salicylate 8 mg/mL, every 2 hours could neither maintain a sustained contraction of the ciliary muscle nor abolish the hypotensive effect of latanoprost in healthy volunteers. The authors believe that pretreatment with a cholinergic agonist should not prevent latanoprost from reaching the FP receptors in human ciliary muscles.…”

The Effectiveness and Safety of Brimonidine as Mono-, Combination, or Replacement Therapy for Patients with Primary Open-Angle Glaucoma or Ocular Hypertension: A Post Hoc Analysis of an Open-Label Community Trial

“…The efficacy of antiglaucoma medications varies and depends upon whether they are used as mono-or combination therapy (7)(8)(9)(10)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28). By grouping patient data according to the specific drag regimen used by each patient, our study evaluated this potential interaction.…”

The Glaucoma Guidelines of the Swedish Ophthalmological Society

“…Notwithstanding, the use of prostaglandin analogues combined with cholinergic agonists such as pilocarpine has been questioned because contraction of the ciliary body might prevent a prostaglandin analogue from reaching its target – the ciliary muscle. However, the intense contraction of the ciliary muscle is of short duration, and the pressure‐lowering effect has been found to be additive (Friström & Nilsson 1993; Lindén & Alm 1997).…”

Use of latanoprost to reduce acute intraocular pressure rise following neodymium: Yag laser iridotomy

“…Pressure spikes after LI occur most frequently within the first 2 hours (Robin & Pollack 1984), while the IOP‐lowering effect of latanoprost reaches its peak 8–12 hours after administration (Villumsen & Alm 1992; Watson et al. 1996; Lindén & Alm 1997). In the present study, latanoprost was instilled 90 min before LI for reasons of practice feasibility so that patients did not have to spend a long time waiting in hospital.…”

“…Clinical study, however, shows a partially additive hypotensive effect when PGF 2 α is combined with pilocarpine (Friström & Nilsson 1993). Furthermore, Lindén & Alm (1997) demonstrated that administration of a strong cholinergic agent, physostigmine salicylate 8 mg/mL, every 2 hours could neither maintain a sustained contraction of the ciliary muscle nor abolish the hypotensive effect of latanoprost in healthy volunteers. The authors believe that pretreatment with a cholinergic agonist should not prevent latanoprost from reaching the FP receptors in human ciliary muscles.…”

The Effectiveness and Safety of Brimonidine as Mono-, Combination, or Replacement Therapy for Patients with Primary Open-Angle Glaucoma or Ocular Hypertension: A Post Hoc Analysis of an Open-Label Community Trial

“…The efficacy of antiglaucoma medications varies and depends upon whether they are used as mono-or combination therapy (7)(8)(9)(10)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28). By grouping patient data according to the specific drag regimen used by each patient, our study evaluated this potential interaction.…”

The Glaucoma Guidelines of the Swedish Ophthalmological Society

“…Notwithstanding, the use of prostaglandin analogues combined with cholinergic agonists such as pilocarpine has been questioned because contraction of the ciliary body might prevent a prostaglandin analogue from reaching its target – the ciliary muscle. However, the intense contraction of the ciliary muscle is of short duration, and the pressure‐lowering effect has been found to be additive (Friström & Nilsson 1993; Lindén & Alm 1997).…”

Use of latanoprost to reduce acute intraocular pressure rise following neodymium: Yag laser iridotomy

“…Pressure spikes after LI occur most frequently within the first 2 hours (Robin & Pollack 1984), while the IOP‐lowering effect of latanoprost reaches its peak 8–12 hours after administration (Villumsen & Alm 1992; Watson et al. 1996; Lindén & Alm 1997). In the present study, latanoprost was instilled 90 min before LI for reasons of practice feasibility so that patients did not have to spend a long time waiting in hospital.…”

“…Clinical study, however, shows a partially additive hypotensive effect when PGF 2 α is combined with pilocarpine (Friström & Nilsson 1993). Furthermore, Lindén & Alm (1997) demonstrated that administration of a strong cholinergic agent, physostigmine salicylate 8 mg/mL, every 2 hours could neither maintain a sustained contraction of the ciliary muscle nor abolish the hypotensive effect of latanoprost in healthy volunteers. The authors believe that pretreatment with a cholinergic agonist should not prevent latanoprost from reaching the FP receptors in human ciliary muscles.…”

The Effectiveness and Safety of Brimonidine as Mono-, Combination, or Replacement Therapy for Patients with Primary Open-Angle Glaucoma or Ocular Hypertension: A Post Hoc Analysis of an Open-Label Community Trial

“…The efficacy of antiglaucoma medications varies and depends upon whether they are used as mono-or combination therapy (7)(8)(9)(10)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28). By grouping patient data according to the specific drag regimen used by each patient, our study evaluated this potential interaction.…”

The Glaucoma Guidelines of the Swedish Ophthalmological Society

“…Notwithstanding, the use of prostaglandin analogues combined with cholinergic agonists such as pilocarpine has been questioned because contraction of the ciliary body might prevent a prostaglandin analogue from reaching its target – the ciliary muscle. However, the intense contraction of the ciliary muscle is of short duration, and the pressure‐lowering effect has been found to be additive (Friström & Nilsson 1993; Lindén & Alm 1997).…”