Laser- synthesized TiN nanoparticles as promising plasmonic alternative for biomedical applications

Abstract

Exhibiting a red-shifted absorption/scattering feature compared to conventional plasmonic metals, titanium nitride nanoparticles (TiN NPs) look as very promising candidates for biomedical applications, but these applications are still underexplored despite the presence of extensive data for conventional plasmonic counterparts. Here, we report the fabrication of ultrapure, size-tunable TiN NPs by methods of femtosecond laser ablation in liquids and their biological testing. We show that TiN NPs demonstrate strong and broad plasmonic peak around 640–700 nm with a significant tail over 800 nm even for small NPs sizes (<7 nm). In vitro tests of laser-synthesized TiN NPs on cellular models evidence their low cytotoxicity and excellent cell uptake. We finally demonstrate a strong photothermal therapy effect on U87–MG cancer cell cultures using TiN NPs as sensitizers of local hyperthermia under near-infrared laser excitation. Based on absorption band in the region of relative tissue transparency and acceptable biocompatibility, laser-synthesized TiN NPs promise the advancement of biomedical modalities employing plasmonic effects, including absorption/scattering contrast imaging, photothermal therapy, photoacoustic imaging and SERS.

SrAl12O19: Fe3+ @3‐aminopropyl triethoxysilane: Ambient aqueous stable near‐infrared persistent luminescent nanocomposites

“…It is higher than the stability threshold (20 mV) for colloidal solutions. 32 After accomplishing the surface functionalization, it is very necessary to rerecognize the morphological characteristics of SrAl 12 O 19 : Fe 3+ @ APTES. SrAl 12 O 19 : Fe 3+ @APTES presented consistent previous shape with APTES-free SrAl 12 O 19 : Fe 3+ nanoparticles ( Figure 3D).…”

Laser-Ablative Synthesis of Stable Aqueous Solutions of Elemental Bismuth Nanoparticles for Multimodal Theranostic Applications

“…When ablated in a pure ambient (deionized water, ethanol, acetone, etc. ), the formed NPs are exempt of any toxic contamination, which opens up avenues for the synthesis of different nanomaterials for biological use, including Au NPs [15][16][17][18], Si NPs [19,20], TiN NPs [21], and Sm [22]. Methods of laser ablation have already been explored for the fabrication of Bi-based nanomaterials [23][24][25][26][27].…”

Texture and Stress Evolution in HfN Films Sputter-Deposited at Oblique Angles

“…However, studies on transition metal nitride (TMN) films produced at OAD or GLAD conditions remain relatively underexplored [16][17][18][19][20][21]. Long-used as protective hard coatings, for which achieving a dense and compact microstructure is a pre-requisite, TMN are foreseen as promising candidate materials for plasmonic and sensing applications [22][23][24]. Therefore, their synthesis by OAD offers an alternative bottom-up route of technological interest to produce nanoparticles or nanostructured layers with enhanced specific surface area or engineerable chiral properties [25].…”