Laser phototherapy as topical prophylaxis against head and neck cancer radiotherapy‐induced oral mucositis: Comparison between low and high/low power lasers

Simões, Alyne; Eduardo, Fernanda de Paula; Luiz, Ana Cláudia; Campos, Luana; N., Pedro Henrique R.; Cristofaro, M. L. De; Marques, Márcia Martins; Eduardo, Carlos

doi:10.1002/lsm.20758

Cited by 101 publications

(78 citation statements)

References 36 publications

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“…[3][4][5][6] Studies on the effects of LPT, either alone or in combination with other therapies, conducted in patients with immunosuppression, have shown that LPT promotes a reduction in pain intensity and mucositis severity, acceleration of wound healing, analgesic effects and an increase in the salivary flow rate, with no side effects. [3][4][7][8] Studies involving animal models allow a better understanding of the pathobiology of mucositis and a more in-depth evaluation of the effects of therapies for the prevention and treatment of this disease. The model for induced mucositis in hamsters was initially proposed by Sonis et al 9 and has proven useful in preclinical studies on new treatment options for mucositis.…”

Section: Introductionmentioning

confidence: 99%

Effect of laser phototherapy in the prevention and treatment of chemo-induced mucositis in hamsters

Lopez¹,

Martins²,

Pavesi

et al. 2013

Braz. oral res.

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The aim of this study was to investigate the effect of laser phototherapy (LPT) in the prevention and/or treatment of oral mucositis induced by 5-fluorouracil (5-FU; Eurofarma, São Paulo, Brazil) in hamsters. Ninety-six hamsters were divided into four groups (n = 24): Control (no treatment); Preventive [LPT from day (D) D−5 to D+5]; Therapeutic (LPT from D+5 to D+15); and Combined (preventive plus therapeutic LPT from D−5 to D+15). The animals received an intraperitoneal injection of 5-FU on Days 0 and 2. The pouch mucosa was scratched on Days 3 and 4. The irradiation parameters were: indium-gallium-aluminum-phosphide (InGaAlP) diode laser (MM Optics, São Carlos, Brazil) (660 nm), beam area of 0.036 cm², 40 mW, 1.11 W/cm², 6.6 J/cm², power density applied daily of 39.6 J/cm², in punctual mode (six points and six seconds per point) and contact mode, one application per day. The animals were sacrificed on Days 0, 5, 10 and 15 (n = 6) and weighed, and the pouch mucosa was removed for histopathological analysis. Clinical and corresponding histological scores were compared using ANOVA and Tukey's test (p ≤ 0.05). Similar weight losses ranging from 5% to 10% occurred in all groups. The therapeutic group had significantly lower clinical and histological scores than the other groups at Day 10. This study showed that positive effects on oral mucositis management were obtained only when LPT was applied in the therapeutic protocol (from D+5 to D+15 after chemotherapy).

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Section: Introductionmentioning

confidence: 99%

Effect of laser phototherapy in the prevention and treatment of chemo-induced mucositis in hamsters

Lopez¹,

Martins²,

Pavesi

et al. 2013

Braz. oral res.

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“…Par la suite, plusieurs types de lasers de basse énergie ont été évalués dans cette indication. Ainsi, Arora et al [15]. Ils rapportent un meilleur contrôle de l'intensité de la douleur avec le laser de plus faible énergie avec un protocole de 3 fois/semaine.…”

Section: Commentairesunclassified

“…Il semble que les protocoles sur 2 à 3 jours/semaine soient plus efficaces que les protocoles proposant 1 utilisation/semaine. Simoes et al ont obtenu de meilleurs résultats avec le laser de plus faible énergie [15]. Ces résultats restent à confirmer et des études supplémentaires devront préciser les paramètres suivant : le type de laser et sa longueur d'onde, la puissance et l'énergie administrée par cm 2 .…”

Section: Commentairesunclassified

Intérêt de la photothérapie au laser pour le traitement des mucites de la cavité buccale. Présentation d’un cas et revue de la littérature

Lescaille

Lang

Ernenwein

et al. 2010

Med Buccale Chir Buccale

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Mots clés : mucite buccale / laser / douleur / cancers des voies aéro-digestivesRésumé -La mucite est une complication classique de la radiothérapie et/ou de la chimiothérapie dans le traitement des cancers des voies aéro-digestives supérieures. Sa prise en charge est avant tout symptomatique : prescription d'un traitement antalgique, topique et systémique. Depuis quelques années, l'utilisation de différents lasers s'est révélée particulièrement intéressante pour le traitement préventif et curatif des mucites radio et/ou chimio-induites. L'objectif de cet article est de faire le point sur les mécanismes d'action du laser de basse énergie et ses indications dans le traitement de lésions muqueuses spécifiques. Nous rapportons ici l'exemple d'un cas de mucite de grade 3 radio-induite chez un patient en cours de radiothérapie postopératoire pour un carcinome épidermoïde du rebord maxillaire. La prise en charge classique (soins locaux et antalgiques) a été mise en place, en association avec des séances de laser Nd :YAP (1,34 μm). Le retour à une toxicité muqueuse ≤ 2 et une cicatrisation de la plupart des zones ulcérées ont été observés dès la première semaine d'application. Parallèlement, un effet antalgique rapide était constaté avec une diminution de la douleur qui est passée de 90 à 30 sur l'EVA.Key words: oral mucositis / laser / pain / head and neck cancers Abstract -Lasers in the treatment of oral mucositis. Report of a case and review of littérature. The mucositis is a common complication of radiotherapy and/or chemotherapy in the treatment of head and neck cancers. Its management is symptomatic with topical and systemic analgesics. In recent years, the use of various lasers has proved particularly interesting for the preventive and curative treatment of mucositis induced by radiotherapy and chemotherapy. The aim of this article is to review the mechanisms of action of low energy laser and its indications in the treatment of mucosal lesion. We report here the case of mucositis grade 3 radiation-induced in a patient during postoperative radiotherapy for squamous cell carcinoma of the maxillary. Classical treatment (local care and analgesics) was set up in conjunction with sessions of Nd:YAP (1.34 mm). The return to ≤ 2 mucosal toxicity and scarring of the ulcerated areas were most observed in the first week of application. Meanwhile a rapid analgesic effect was observed with a decrease in pain that went from 90-30 on the VAS.La radiothérapie, exclusive ou postopératoire, occupe une place fondamentale dans le traitement des cancers des voies aéro-digestives supérieures. Dans les formes avancées, le bé-néfice d'une chimiothérapie concomitante à l'irradiation a été clairement démontré : elle permet d'améliorer le contrôle local

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“…Em odontologia, o uso da LLLT tem se tornado cada vez mais difundido e, dentre suas aplicações, podem ser citados a prevenção e aceleração da reparação de lesões de herpes labial recorrente (177)(178)(179)(180)(181) , prevenção e tratamento da mucosite oral (182)(183)(184)(185) , tratamento de parestesia do nervo trigêmeo (186,187) , além do auxílio no tratamento de disfunções temporomandibulares (188)(189)(190) .…”

Section: Laser Em Baixa Intensidadeunclassified

Análise da expressão e mecanismos de ação das proteínas Akt, Hsp90, mTOR e ciclina D1 em cultura de células de carcinoma epidermoide humano e células displásicas após irradiação com laser em baixa intensidade

Sperandio¹

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Laser phototherapy as topical prophylaxis against head and neck cancer radiotherapy‐induced oral mucositis: Comparison between low and high/low power lasers

Abstract: These findings are desired when dealing with oncologic patients under RT avoiding unplanned radiation treatment breaks and additional hospital costs.

Cited by 101 publications

References 36 publications

Effect of laser phototherapy in the prevention and treatment of chemo-induced mucositis in hamsters

Effect of laser phototherapy in the prevention and treatment of chemo-induced mucositis in hamsters

Intérêt de la photothérapie au laser pour le traitement des mucites de la cavité buccale. Présentation d’un cas et revue de la littérature

Análise da expressão e mecanismos de ação das proteínas Akt, Hsp90, mTOR e ciclina D1 em cultura de células de carcinoma epidermoide humano e células displásicas após irradiação com laser em baixa intensidade

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