Laser-Induced Primate Glaucoma

MK-927: A Topically Active Ocular Hypotensive Carbonic Anhydrase Inhibitor

“…The changes to the optic nerve head in cynomolgus monkeys following argon laser-induced ocular hypertension are similar to those observed in human eyes with glaucoma (11,12). The IOP of ocular hypertensive, cynomolgus monkeys is decreased by the acute (10) and the repeated instillation (13) of a range of clinically used ocular hypotensive agents.…”

MK-927: A Topically Active Ocular Hypotensive Carbonic Anhydrase Inhibitor

“…The changes to the optic nerve head in cynomolgus monkeys following argon laser-induced ocular hypertension are similar to those observed in human eyes with glaucoma (11,12). The IOP of ocular hypertensive, cynomolgus monkeys is decreased by the acute (10) and the repeated instillation (13) of a range of clinically used ocular hypotensive agents.…”

Glaucoma as a neurodegenerative disease

“…Glaucoma from the eye to the brain As in human glaucoma, elevated IOP in the monkey eye can produce RGC death, with characteristic optic nerve head changes including excavation [24]. Glaucoma is generally considered to be a disease of the eye; however, most of the RGC axon is extra-ocular, with prechiasmal, chiasmal and postchiasmal components.…”

L‐662,583 is a topically effective ocular hypotensive carbonic anhydrase inhibitor in experimental animals

“…The changes to the optic nerve head in cynomolgus monkeys following argon laser-induced ocular hypertension are similar to those in human eyes with glaucoma (Radius & Pederson, 1984;Marx et al, 1988). The intraocular pressure of unilateral, ocular hypertensive, cynomolgus monkeys is decreased by the acute (Lee et al, 1985) and repeated instillation (Lee et al, 1987) of a range of clinically used ocular hypotensive agents.…”

MK-927: A Topically Active Ocular Hypotensive Carbonic Anhydrase Inhibitor

“…The changes to the optic nerve head in cynomolgus monkeys following argon laser-induced ocular hypertension are similar to those observed in human eyes with glaucoma (11,12). The IOP of ocular hypertensive, cynomolgus monkeys is decreased by the acute (10) and the repeated instillation (13) of a range of clinically used ocular hypotensive agents.…”

Glaucoma as a neurodegenerative disease

“…Glaucoma from the eye to the brain As in human glaucoma, elevated IOP in the monkey eye can produce RGC death, with characteristic optic nerve head changes including excavation [24]. Glaucoma is generally considered to be a disease of the eye; however, most of the RGC axon is extra-ocular, with prechiasmal, chiasmal and postchiasmal components.…”

L‐662,583 is a topically effective ocular hypotensive carbonic anhydrase inhibitor in experimental animals

“…The changes to the optic nerve head in cynomolgus monkeys following argon laser-induced ocular hypertension are similar to those in human eyes with glaucoma (Radius & Pederson, 1984;Marx et al, 1988). The intraocular pressure of unilateral, ocular hypertensive, cynomolgus monkeys is decreased by the acute (Lee et al, 1985) and repeated instillation (Lee et al, 1987) of a range of clinically used ocular hypotensive agents.…”

MK-927: A Topically Active Ocular Hypotensive Carbonic Anhydrase Inhibitor

“…The changes to the optic nerve head in cynomolgus monkeys following argon laser-induced ocular hypertension are similar to those observed in human eyes with glaucoma (11,12). The IOP of ocular hypertensive, cynomolgus monkeys is decreased by the acute (10) and the repeated instillation (13) of a range of clinically used ocular hypotensive agents.…”

Glaucoma as a neurodegenerative disease

“…Glaucoma from the eye to the brain As in human glaucoma, elevated IOP in the monkey eye can produce RGC death, with characteristic optic nerve head changes including excavation [24]. Glaucoma is generally considered to be a disease of the eye; however, most of the RGC axon is extra-ocular, with prechiasmal, chiasmal and postchiasmal components.…”

L‐662,583 is a topically effective ocular hypotensive carbonic anhydrase inhibitor in experimental animals

“…The changes to the optic nerve head in cynomolgus monkeys following argon laser-induced ocular hypertension are similar to those in human eyes with glaucoma (Radius & Pederson, 1984;Marx et al, 1988). The intraocular pressure of unilateral, ocular hypertensive, cynomolgus monkeys is decreased by the acute (Lee et al, 1985) and repeated instillation (Lee et al, 1987) of a range of clinically used ocular hypotensive agents.…”