Laser-generated bismuth nanoparticles for applications in imaging and radiotherapy

Torrisi, L.; Silipigni, L.; Restuccia, N.; Cuzzocrea, Salvatore; Cutroneo, M.; Barreca, Francesco; Fazio, Barbara; Marco, G. Di; Guglielmino, Salvatore

doi:10.1016/j.jpcs.2018.03.034

Cited by 50 publications

(27 citation statements)

References 21 publications

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“…The signal from Na comes from the surfactant compounds used at a very low concentration to stabilize the Bi NPs. The O low presence indicates that the Bi is metallic and it is very little oxidized, as confirmed by our Raman spectroscopy, XRD, and XPS spectroscopy analyses and in agreement with the literature [8,9]. vol.…”

Section: Resultssupporting

confidence: 92%

Metallic Nanoparticles Generation by Repetitive Pulsed Laser for Applications in Bio-Medicine

Restuccia

Silipigni

Cordaro

et al. 2019

PPT

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A Nd:YAG pulsed laser operating at the 1064 nm wavelength, the 3 ns pulse duration, the 1010 W/cm2 intensity and the 10 Hz repetition rate is employed to irradiate biocompatible metallic targets based on Au, Bi and Ag placed in water. The laser-matter interaction produces nanometric spherical particles. The concentration of the solution with nanoparticles is controllable by the laser parameters, the ablative emission process, the irradiation time and the water’s volume. Generally, nanoparticles of about 10 nm in size and concentrations of the order (0.1 ÷ 10) mg/ml are prepared to be injected in cell cultures or in living systems (mice). The nanoparticles introduction in the extra and intra cellular liquids improves the bio-imaging of the tissue and organs by using fluorescence techniques. Moreover, if these nanoparticles are concentrated in tumour cells, they make possible high efficiency radio-therapy and thermal-therapy treatments, as it will be presented and discussed.

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Section: Resultssupporting

confidence: 92%

Metallic Nanoparticles Generation by Repetitive Pulsed Laser for Applications in Bio-Medicine

Restuccia

Silipigni

Cordaro

et al. 2019

PPT

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“…Bismuth nanoparticles with a size of 25 nm were successfully synthesized by using the laser ablation method, and they can be utilized as high contrast medium for high-resolution imaging in several biological applications [30]. Notably, bismuth nanoparticles synthesized by conventional solvent techniques have a size in the range of 50-103 nm with a very high anti-wear property [31].…”

Section: Introductionmentioning

confidence: 99%

Use of A Hydroalcoholic Extract of Moringa oleifera Leaves for the Green Synthesis of Bismuth Nanoparticles and Evaluation of Their Anti-Microbial and Antioxidant Activities

Das¹,

Majdalawieh

Abu‐Yousef

et al. 2020

Materials

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The employment of plant extracts in the synthesis of metal nanoparticles is a very attractive approach in the field of green synthesis. To benefit from the potential synergy between the biological activities of the Moringa oleifera and metallic bismuth, our study aimed to achieve a green synthesis of phytochemical encapsulated bismuth nanoparticles using a hydroalcoholic extract of M. oleifera leaves. The total phenolic content in the M. oleifera leaves extract used was 23.0 ± 0.3 mg gallic acid equivalent/g of dried M. oleifera leaves powder. The physical properties of the synthesized bismuth nanoparticles were characterized using UV-Vis spectrophotometer, FT-IR spectrometer, TEM, SEM, and XRD. The size of the synthesized bismuth nanoparticles is in the range of 40.4–57.8 nm with amorphous morphology. Using DPPH and phosphomolybdate assays, our findings revealed that the M. oleifera leaves extract and the synthesized bismuth nanoparticles possess antioxidant properties. Using resazurin microtiter assay, we also demonstrate that the M. oleifera leaves extract and the synthesized bismuth nanoparticles exert potent anti-bacterial activity against Escherichia coli, Klebsiella pneumoniae, Staphylococcus aureus, and Enterococcus faecalis (estimated MIC values for the extract: 500, 250, 250, and 250 µg/mL; estimated MIC values for the bismuth nanoparticles: 500, 500, 500, and 250 µg/mL, respectively). Similarly, the M. oleifera leaves extract and the synthesized bismuth nanoparticles display relatively stronger anti-fungal activity against Aspergillus niger, Aspergillus flavus, Candida albicans, and Candida glabrata (estimated MIC values for the extract: 62.5, 62.5, 125, and 250 µg/mL; estimated MIC values for the bismuth nanoparticles: 250, 250, 62.5, and 62.5 µg/mL, respectively). Thus, green synthesis of bismuth nanoparticles using M. oleifera leaves extract was successful, showing a positive antioxidant, anti-bacterial, and anti-fungal activity. Therefore, the synthesized bismuth nanoparticles can potentially be employed in the alleviation of symptoms associated with oxidative stress and in the topic treatment of Candida infections.

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“…To date, several strategies have been developed for the synthesis of pure bismuth nanomaterials since it is a well-known “green element” that is inexpensive and relatively nontoxic among the heavy metals. 10 These commonly employed methods are mainly divided into the following four categories: (i) thermal decomposition, 11 (ii) mechanochemical processing, 6a,12 (iii) photochemical, 13 and (iv) solution-phase chemical reduction methods. 2,4,6c,14 Generally, the thermal decomposition method could be used to obtain high-quality monodisperse elemental bismuth nanoparticles.…”

Section: Introductionmentioning

confidence: 99%

Facile Aqueous-Phase Synthesis of an Ultrasmall Bismuth Nanocatalyst for the Reduction of 4-Nitrophenol

et al. 2019

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Bismuth metallic nanoparticles have evoked considerable interest in catalysis owing to their small size, high surface area-to-volume ratio, and low toxicity. However, the need for toxic reductants and organic solvents in their synthesis often limits their desirability for application development. Here, we describe a green strategy to synthesize bismuth nanodots via the redox reactions between bismuth nitrate and d-glucose, in the presence of poly(vinylpyrrolidone) in the basic aqueous phase. Both reagents play a crucial role in the formation of monodisperse bismuth nanodots acting as mild reducing and capping agents, respectively. We further demonstrate that the catalytic activity of these dots via the successful reduction of the environmental contaminant 4-nitrophenol to its useful 4-aminophenol analogue requiring only 36 μg/mL nanocatalyst for 20 mM of the substrate. Moreover, they can be recovered and recycled in multiple reactions before the onset of an appreciable loss of catalytic activity. The proposed facile synthetic route and inexpensive matrix materials lead the way to access bismuth nanodots for both the fundamental study of reactions and their industrial catalysis applications.

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Laser-generated bismuth nanoparticles for applications in imaging and radiotherapy

Cited by 50 publications

References 21 publications

Metallic Nanoparticles Generation by Repetitive Pulsed Laser for Applications in Bio-Medicine

Metallic Nanoparticles Generation by Repetitive Pulsed Laser for Applications in Bio-Medicine

Use of A Hydroalcoholic Extract of Moringa oleifera Leaves for the Green Synthesis of Bismuth Nanoparticles and Evaluation of Their Anti-Microbial and Antioxidant Activities

Facile Aqueous-Phase Synthesis of an Ultrasmall Bismuth Nanocatalyst for the Reduction of 4-Nitrophenol

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