Laser Doppler perfusion imaging in systemic sclerosis impaired response to cold stimulation involves digits and hand dorsum

Abstract

In early SSc, the thermoregulation of finger skin is impaired, but only in advanced stages of microangiopathy does the skin of the hand dorsum show a vasomotor control failure.

In systemic sclerosis macrovascular damage of hands digital arteries correlates with microvascular damage

“…Therefore, for an accurate assessment of the functional flow in LDPI is necessary to test vasoreactivity. In fact, in our study after a cold test we have shown that perfusion of the hand dorsum of SSc patients has different characteristics in the three capillaroscopic patterns (Rosato et al, 2011c).…”

Skin Perfusion of Fingers Shows a Negative Correlation with Capillaroscopic Damage in Patients with Systemic Sclerosis

“…However, a combination of all 3 techniques improves classification Mugii 9 127 NVC Red blood cell velocity was significantly associated with NVC findings. Patients with the scleroderma active and late NVC pattern showed a lower red blood cell velocity compared with scleroderma early pattern Rosato 10 40 LDI and NVC In early SSc, thermoregulation of finger skin is impaired. With progression of NVC damage, the abnormal microvascular response to cold stimulation also appears in the hand dorsum skin LDI: laser Doppler imaging; LDF: laser Doppler flowmetry; NFC: nailfold capillaroscopy; NVC: nailfold videocapillaroscopy; PPG: photoplethysmography.…”

Getting in touch with Raynaud phenomenon

“…3,4 Nailfold video capillaroscopy, also known as nailfold capillary microscopy (NCM), helps detect abnormal capillaries associated with CTD, such as systemic sclerosis. 3,4,6 Results of Ms. J' s blood work and NCM don't suggest underlying CTD or other underlying disorder, so Ms. J will be treated for PRP. 12…”

“…[2][3][4] Attacks are often painful and may be associated with paresthesia, numbness, and impaired hand function. 6 RP usually affects fingers and toes, but the nose, ears, and lips can be affected as well. 2…”