Laser and light-based therapy for cutaneous and soft-tissue metastases of malignant melanoma: a systematic review

Austin, Evan; Mamalis, Andrew; Ho, Derek; Jagdeo, Jared

doi:10.1007/s00403-017-1720-9

Cited by 31 publications

(22 citation statements)

References 45 publications

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“…We observed that microscopic satellitosis does not necessarily translate into the lymphovascular infiltration of the tumour [ 13 ]. In one study, the 5-year overall and disease-free survivals in patients with microscopic satellitosis were 34% and 18%, respectively, demonstrating an unfortunate prognosis [ 14 ].…”

Section: Discussionmentioning

confidence: 99%

Scalping Surgery – Dermatologic Indications beyond Curative Primary Skin Cancer Surgery

Wollina¹,

Langner²,

Hansel³

et al. 2017

Open Access Maced J Med Sci

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Skin tumours are among the most frequent tumour types of mankind. In the case of large tumours, field cancerization, or satellitosis scalping surgery is a possible option. The procedure can also be used in a palliative setting with tumour debulking. Less common indications are multiple benign tumours of the scalp and chronic inflammatory scalp dermatoses not responding to medical treatment. We present a case series and discuss surgical modalities beyond curative surgery of primary skin cancer.

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Section: Discussionmentioning

confidence: 99%

Scalping Surgery – Dermatologic Indications beyond Curative Primary Skin Cancer Surgery

Wollina¹,

Langner²,

Hansel³

et al. 2017

Open Access Maced J Med Sci

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“…Photodynamic therapy (PDT) is a light-based therapy. It represents a promising adjuvant treatment and can be used as a palliative method of choice for patients with stage III/IV cutaneous metastatic melanomas [24]. PDT is considered a minimally invasive procedure that requires a photosensitizer.…”

Section: Introductionmentioning

confidence: 99%

“…PDT is considered a minimally invasive procedure that requires a photosensitizer. Absorption is superior in metabolically active tissues [24]. The method applies non-toxic compounds, which create reactive oxygen species (ROS) when combined with oxygen [25].…”

Section: Introductionmentioning

confidence: 99%

Viral Vector-Based Melanoma Gene Therapy

Hromić‐Jahjefendić

Lundström²

2020

Biomedicines

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Gene therapy applications of oncolytic viruses represent an attractive alternative for cancer treatment. A broad range of oncolytic viruses, including adenoviruses, adeno-associated viruses, alphaviruses, herpes simplex viruses, retroviruses, lentiviruses, rhabdoviruses, reoviruses, measles virus, Newcastle disease virus, picornaviruses and poxviruses, have been used in diverse preclinical and clinical studies for the treatment of various diseases, including colon, head-and-neck, prostate and breast cancer as well as squamous cell carcinoma and glioma. The majority of studies have focused on immunotherapy and several drugs based on viral vectors have been approved. However, gene therapy for malignant melanoma based on viral vectors has not been utilized to its full potential yet. This review represents a summary of the achievements of preclinical and clinical studies using viral vectors, with the focus on malignant melanoma.

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“…Several lasers have been used to treat melanocytic proliferations, such as CO 2 , Q-switched ruby, Nd:YAG, argon, and alexandrite [12][13][14] . These lasers have been used for palliative treatment of melanoma metastases, but they are not ordinarily used for therapy of primary melanoma [ 15 ] .…”

Section: Introductionmentioning

confidence: 99%

The use of 2940‐nm ER:YAG laser for the treatment of lentigo maligna

Fikrle

Divišová

Šuchmannová

et al. 2019

J Deutsche Derma Gesell

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ZusammenfassungZiele: Die Lentigo maligna ist ein bei älteren Patienten häufig auftretendes malignes Carcinoma in situ mit einem geringen invasiven Progressionsrisiko. Da ein chirurgisches Vorgehen schwierig sein kann oder vom Patienten abgelehnt wird, besteht ein Bedarf an nichtoperativen Therapieoptionen wie beispielsweise eine Laserbehandlung. Patienten und Methoden: Wir berichten über 17 Patienten, die wegen einer histopathologisch gesicherten Lentigo maligna mit einem 2940 nm Er:YAG-Laser (Erbium-dotierter Yttrium-Aluminium-Granat-Laser) behandelt wurden. Die Ablation der Läsionen schloss einen Sicherheitsabstand von 5 mm ein und wurde unter Lokalanästhesie mit überlappenden Laserspots (3,5 mm), einer Energiedichte von 6,5 J/cm 2 und einer Wiederholungsrate von 5 Hz durchgeführt. Trat im abladierten Bereich während der nachfolgenden drei Monate eine klinisch erkennbare Pigmentierung auf, wurde die Läsion erneut behandelt. Bei allen Patienten erfolgte eine Nachkontrolle auf residuale oder rezidivierende Tumoren. Ergebnisse: Wir konnten bei allen 17 Patienten klinische Tumorfreiheit erreichen. Während der Nachsorge traten drei Rezidive auf (9, 30 und 36 Monate nach der Laserbehandlung). Alle Patienten waren mit dem Behandlungsverlauf und dem kosmetischen Ergebnis zufrieden. Die mittlere Dauer der Nachkontrolle betrug 28 Monate. Schlussfolgerungen: Die Laserablation ist eine interessante alternative Therapieoption bei Lentigo maligna. Sie kann in ausgewählten Fällen eingesetzt werden, bei denen ein chirurgisches Vorgehen kontraindiziert oder schwierig ist oder vom Patienten abgelehnt wird. SummaryObjectives: Lentigo maligna is a common in situ malignancy in elderly patients, with a low risk of progression to an invasive tumor. Surgical treatment may be complicated or refused. Non-surgical treatment options (such as lasers) may therefore be needed. Patients and Methods: We report on 17 patients treated with a 2940-nm Er:YAG (erbium-doped yttrium aluminum) laser for histopathologically confirmed lentigo maligna. The lesions were ablated with a 5 mm margin of adjacent skin under local anesthesia with a 3.5 mm overlapping spot, energy density of 6.5 J/cm 2 and a repetition rate of 5 Hz. If clinically visible pigmentation was seen in the ablated area during the following three months, the lesion was re-treated. All patients were followed up for residual or recurrent tumors. Results: We achieved clinical clearance in all 17 patients. There were three recurrences during the follow-up period (9, 30 and 36 months after laser therapy). All patients were satisfied with the treatment course and cosmetic outcome. The mean follow-up duration was 28 months.

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Laser and light-based therapy for cutaneous and soft-tissue metastases of malignant melanoma: a systematic review

Cited by 31 publications

References 45 publications

Scalping Surgery – Dermatologic Indications beyond Curative Primary Skin Cancer Surgery

Scalping Surgery – Dermatologic Indications beyond Curative Primary Skin Cancer Surgery

Viral Vector-Based Melanoma Gene Therapy

The use of 2940‐nm ER:YAG laser for the treatment of lentigo maligna

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