Laser Ablation of Liver Metastases from Colorectal Cancer with MR Thermometry: 5-Year Survival

Puls, Ralf; Langner, Soenke; Rosenberg, Christian; Hegenscheid, Katrin; Kuehn, Jens Peter; Noeckler, K.; Hosten, Norbert

doi:10.1016/j.jvir.2008.10.018

Cited by 53 publications

(32 citation statements)

References 36 publications

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“…Recently, MR-thermometry has evolved to the method of choice for monitoring and guiding thermal therapies such as radio-frequency [1], laser [2] or HIFU thermal ablation [3]. The availability in real time of temperature information is required for several aspects of the therapeutic intervention.…”

Section: Introductionmentioning

confidence: 99%

Robust Adaptive Extended Kalman Filtering for Real Time MR-Thermometry Guided HIFU Interventions

Roujol

Senneville

Hey

et al. 2012

IEEE Trans. Med. Imaging

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Abstract-Real time magnetic resonance (MR) thermometry is gaining clinical importance for monitoring and guiding high intensity focused ultrasound (HIFU) ablations of tumorous tissue. The temperature information can be employed to adjust the position and the power of the HIFU system in real time and to determine the therapy endpoint.The requirement to resove both physiological motion on mobile organs and the rapid temperature variations induced by state-ofthe art high-power HIFU systems requires fast MRI-acquisition schemes, which are generally hampered by low signal to noise ratios (SNR). This directly limits the precision of real time MR-thermometry and thus in many cases the feasability of sophisticated control algorithms. To overcome these limitations, temporal filtering of the temperature has been suggested in the past, which has generally an adverse impact on the accuracy and latency of the filtered data.Here, we propose a novel model based digital filter combining an extended Kalman filter (EKF) with a predictive model of the temperature based on the bio heat transfer equation. This filter aims to improve the precision of MR-thermometry while monitoring and adapting its impact on the accuracy using the formalism of adaptive extended Kalman filtering. An additional outlier rejection addresses the problem of sparse artifacted temperature points. The filter was evaluated and compared to a matched FIR filter using simulated data, HIFU experiments on phantoms and in vivo data obtained during HIFU ablations on porcine kidneys. The filter provides improved artefact and noise reduction, while having a minimal impact on accuracy and latency.

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Section: Introductionmentioning

confidence: 99%

Robust Adaptive Extended Kalman Filtering for Real Time MR-Thermometry Guided HIFU Interventions

Roujol

Senneville

Hey

et al. 2012

IEEE Trans. Med. Imaging

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“…The ablation of solid tumors has been investigated using a variety of energy methods, including endogenously absorbed laser energy [1][2][3] and radio-frequency energy. 4,5 The tumor specificity of these approaches is generally limited by the precision of pretreatment imaging, the precision of applicator placement, and the energy-deposition shape of the applicator used ͑generally spherical or conical͒.…”

Section: Introductionmentioning

confidence: 99%

Photothermal therapy in a murine colon cancer model using near-infrared absorbing gold nanorods

et al. 2010

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Abstract. The photothermal ablation of solid tumors using exogenous, near-infrared ͑NIR͒-absorbing nanoparticles has been previously investigated using various preclinical models and is currently being evaluated in the clinic. Here, we evaluate the circulation kinetics, preliminary toxicity, and efficacy of photothermal ablation of solid tumors using gold nanorods systemically delivered and passively accumulated in a murine subcutaneous colon cancer model. Tumored animals were infused with nanorods followed by the percutaneous illumination of the tumor with an 808-nm laser. Control groups consisted of laser-only, nanorod-only, and untreated tumored animals. The survival of the treated and control groups were monitored for 60 days post-treatment. The survival of the photothermally treated group was statistically longer than the control groups, with approximately 44% tumor free through the evaluation period. Histopathology of the major organs of animals infused with nanorods did not indicate any significant toxicity at 60 days post-treatment. Particle biodistribution was evaluated by elemental analysis of the major organs of untumored mice at 1, 7, and 30 days after infusion with nanorods. Elemental analysis indicates nanorod clearance from the blood and retention by the reticuloendothelial system. This study indicates that gold nanorods are promising agents for photothermal ablation of solid tumors.

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“…Over the past two decades, ablative therapies, especially radiofrequency ablation (RFA), have already been used in the management of patients with unresectable CLM to achieve local tumour control [12][13][14][15][16]. In a randomised phase II trial involving patients with liver-limited metastases, Ruers et al [17] reported that systemic chemotherapy combined with RFA achieved significantly longer PFS than systemic chemotherapy alone.…”

Section: Introductionmentioning

confidence: 99%

Impact of timing and cycles of systemic chemotherapy on survival outcome of colorectal liver metastases patients treated by percutaneous microwave ablation

Zhang

Zhou

et al. 2016

International Journal of Hyperthermia

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Laser Ablation of Liver Metastases from Colorectal Cancer with MR Thermometry: 5-Year Survival

Cited by 53 publications

References 36 publications

Robust Adaptive Extended Kalman Filtering for Real Time MR-Thermometry Guided HIFU Interventions

Robust Adaptive Extended Kalman Filtering for Real Time MR-Thermometry Guided HIFU Interventions

Photothermal therapy in a murine colon cancer model using near-infrared absorbing gold nanorods

Impact of timing and cycles of systemic chemotherapy on survival outcome of colorectal liver metastases patients treated by percutaneous microwave ablation

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