Laryngospasm as preceding symptom of amyotrophic lateral sclerosis

Fourcade, G.; Castelnovo, Giovanni; Renard, Dimitri; Labauge, Pierre

doi:10.1007/s00415-010-5626-0

Cited by 3 publications

(2 citation statements)

References 7 publications

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“…A few case reports describe laryngospasm as a rare initial or presenting symptom of ALS. 4,5 Estimates of its prevalence from studies of patients with motor neuron disease and physician surveys range from 2% to 19%, 6,7 numbers that are comparable to the 4% rate reported by Gotesman et al, and similar to rates reported in the otolaryngology literature on bulbar symptoms in ALS. 8,9 Importantly, laryngospasm can be very frightening for patients and their caregivers, a conclusion supported by the authors' finding of frequent anxiety in patients with laryngospasm.…”

supporting

confidence: 72%

“…There are few estimates of the overall frequency of laryngospasm in ALS. A few case reports describe laryngospasm as a rare initial or presenting symptom of ALS 4,5 . Estimates of its prevalence from studies of patients with motor neuron disease and physician surveys range from 2% to 19%, 6,7 numbers that are comparable to the 4% rate reported by Gotesman et al, and similar to rates reported in the otolaryngology literature on bulbar symptoms in ALS 8,9 …”

Section: Epidemiology and Clinical Impactsupporting

confidence: 55%

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Laryngospasm: A frequently underrecognized symptom in amyotrophic lateral sclerosis

Simmons

2022

Muscle and Nerve

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In this issue of Muscle & Nerve, Gotesman et al report their findings from a retrospective review of laryngospasm in a large single-center cohort of patients with amyotrophic lateral sclerosis (ALS). 1Laryngospasm is defined as a paroxysmal episode beginning with the subjective sensation of inability to move air, followed by inspiratory stridor associated with rapid and forceful contraction of the laryngeal sphincter. 2 It can result in the inability to breathe or call for help. 3 Laryngospasm occurs in neurologic conditions affecting the basal ganglia, such as Parkinson disease; disorders of motor neurons, such as ALS, spinal and bulbar muscular atrophy (SBMA), and brainstem infarcts; as well as laryngeal nerve injury following surgery. 2 Laryngospasm is an underrecognized symptom in ALS, with few studies directly assessing its risk factors, frequency, severity, associated triggers, and potential therapies.

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confidence: 72%