Laryngeal candidiasis: Our experience from sixty biopsy specimens

Yao, Alexander; Bates, Timothy; Pearson, J. R. A.; Robinson, Marc; Ward, Chris; Powell, Jason

doi:10.1111/coa.13034

Cited by 3 publications

(7 citation statements)

References 9 publications

(18 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In their study, Sulica 8 reported that of the 8 cases, 6 (75%) were over the age of 60 and 4 of them had vocal fold leukoplakia. In their study, Yao et al 5 found that of 30 cases who used ICS and underwent laryngeal biopsy, 6 had candidiasis, and their mean age was 60 ± 4.6. In the present study, the peak incidence of Candida leukoplakia was significant in the participants over 60 years of age, which is consistent with the literature.…”

Section: Discussionmentioning

confidence: 98%

“…Therefore, the differential diagnosis of VFL lesions that have similar morphological images and different treatment modalities as Candida and non-Candida, determination of possible risk factors, and planning of treatment management are of importance for both patients and otorhinolaryngologist. 5,6,8-10…”

Section: Discussionmentioning

confidence: 99%

“…The comparison of the 2 groups in terms of ICS use demonstrated that ICS use was significant as a risk factor in the Candida group ( P < .001). In their retrospective review, Yao et al 5 performed laryngeal biopsies to investigate the presence of candidiasis with PAS staining and determined that 6 (20%) of 30 patients using ICS had hyphal forms of candidiasis. In their study covering the period between 1968 and 2004, Sulica 8 reported that 5 (62.5%) of the 8 patients used ICS, 3 of them (37.5%) had vocal fold laryngeal candidiasis, and the only risk factor was the use of ICS.…”

Section: Discussionmentioning

confidence: 99%

“…With the accurate histopathological diagnosis, the otorhinolaryngologist identifies the appropriate treatment protocol and protects the patient from undesirable overtreatment or undertreatment. [3][4][5][6] In the literature, the first laryngeal candidiasis case was reported by Tedeschi and Cheren 7 in 1968. The case series mentioning Candida VFL are 4 in total and are presented in Table 1.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Candidiasis Causing Vocal Fold Leukoplakia: Review of Clinical and Pathological Results of 289 Cases With Vocal Fold Leukoplakia

Gümüşsoy

Küçük

2019

Ann Otol Rhinol Laryngol

View full text Add to dashboard Cite

Objective: In laryngology practice, vocal fold leukoplakia is frequently evaluated by suspension laryngoscopy and biopsy examination upon the patient’s complaints of hoarseness and dysphonia. The purpose of the present study is to investigate and analyze risk factors, diagnosis, treatment, and follow-up results of cases with Candida leukoplakia. Study Design: Retrospective case control study. Setting: Tertiary medical center. Subjects and Methods: Patients with a diagnosis of vocal fold leukoplakia who underwent direct laryngoscopy and biopsy between 2007 and 2017 and diagnosed as candida or noncandida in their histopathology were assigned into 2 groups. Then they were compared in terms of their demographic characteristics, predisposing factors, diagnosis, treatment, and follow-up results. Results: Of the 289 vocal fold leukoplakia cases, 36 were candida, and 253 were noncandida. The mean age of the patients with Candida leukoplakia was 60.86 years. As for the age groups, the largest group (26.1%) was in the seventh decade ( P < .001). The use of inhaled corticosteroids was a significant risk factor ( P < .001). For their medical therapy, the patients were administered fluconazole 200 mg per day for 3 weeks, and the treatment yielded successful results in 91.66% of them. In 5 of the patients, candida leukoplakia and superficial epithelial dysplasia were observed, and no malignant transformation was observed during a mean follow-up of 28 ± 13 months. Conclusion: Candidiasis causing vocal fold leukoplakia is rare, and we report the findings of the largest published case series to date. Eliminating predisposing factors and administrating oral fluconazole 200 mg for 3 weeks are sufficient for medical treatment.

show abstract

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Candidiasis Causing Vocal Fold Leukoplakia: Review of Clinical and Pathological Results of 289 Cases With Vocal Fold Leukoplakia

Gümüşsoy

Küçük

2019

Ann Otol Rhinol Laryngol

View full text Add to dashboard Cite

show abstract

Management of laryngeal candidiasis: an evidence-based approach for the otolaryngologist

Valente

Ferreira

Pinto

et al. 2020

Eur Arch Otorhinolaryngol

View full text Add to dashboard Cite

Medications and the larynx

Harounian

Postevka

Jamal

2019

Current Opinion in Otolaryngology &Amp; Head &Amp; Neck Surgery

View full text Add to dashboard Cite

Purpose of review The larynx is a complex organ that houses some of the most intricate structures of the human body. Owing to its delicate nature, the larynx is affected by different medications to varying degrees. Many of these effects manifest in subjective complaints in one's voice or swallow. This review article invokes the present available literature to describe the effects different medical agents have on the functionality of the laryngeal structures. Recent findings Multiple available studies explore the effects of inhaled corticosteroids on the larynx. While laryngeal candidiasis is a well known complication of chronic steroid use, other rarer fungal infections have also demonstrated themselves as risks. Among anesthetics, the literature suggests that sevoflurane in standard and high doses does not appear to significantly reduce the risk of laryngospasm. The use of topical and intravenous lidocaine appear to have conflicting evidence regarding their use in laryngospasm prevention, whereas postoperative sore throat, hoarseness, and cough may be prevented with preinduction nebulization of ketamine and magnesium sulfate or budesonide. Summary Further study is warranted to explore the effects that these and other classes of agents, such as antibiotics, have on the structure and function of the larynx.

show abstract

Laryngeal candidiasis: Our experience from sixty biopsy specimens

Cited by 3 publications

References 9 publications

Candidiasis Causing Vocal Fold Leukoplakia: Review of Clinical and Pathological Results of 289 Cases With Vocal Fold Leukoplakia

Candidiasis Causing Vocal Fold Leukoplakia: Review of Clinical and Pathological Results of 289 Cases With Vocal Fold Leukoplakia

Management of laryngeal candidiasis: an evidence-based approach for the otolaryngologist

Medications and the larynx

Contact Info

Product

Resources

About