Abstract:Basaloid squamous cell carcinoma with spindle cell component is an uncommon aggressive variety of squamous cell carcinoma with only a few reported cases in literature. Histologically a combination of basaloid squamous cell carcinoma and spindle cell squamous cell carcinoma is appreciated and immunohistochemistry serves a role in differentiation from malignant neoplasms of salivary gland or neuro-endocrine origin. Prime treatment modality is combination of surgery and external beam radiotherapy. A case of basal… Show more
“…As one of the common malignancies in the head and neck, laryngeal squamous cell carcinoma (LSCC) brings a huge health burden for patients worldwide 1,2 . The risk factors that contribute to the onset, initiation, and development of LSCC are complicated and include smoking, alcohol drinking, environmental stress, radioactivity, viral infection, and microelement deficiency 3–6 .…”
Aberrant expression or mutation of the Septin gene family is closely associated with cancer progression, and septin 2 (SEPT2) exerts its tumor‐promoting effects in multiple cancers, but its role in regulating laryngeal squamous cell carcinoma (LSCC) progression and drug resistance has not been investigated. Based on the published data, the present study identified that SEPT2 promoted cancer progression and increased cisplatin‐resistance in LSCC, and a novel LncRNA FGD5‐AS1/miR‐497‐5p axis was crucial for this process. Mechanistically, SEPT2 tended to be enriched in LSCC tissues and cells, and knock‐down of SEPT2 inhibited cell proliferation, viability, migration, and tumorigenesis in LSCC cells in vitro and in vivo. Aside from that, SEPT2 overexpression increased cisplatin resistance in LSCC cells. Next, by conducting the dual‐luciferase reporter gene system assay, we identified that the LncRNA FGD5‐AS1/miR‐497‐5p axis regulated SEPT2 in LSCC. Specifically, LncRNA FGD5‐AS1 sponged miR‐497‐5p to upregulate SEPT2 in LSCC cells in a competing endogenous RNA (ceRNA) mechanisms‐dependent manner. Interestingly, upregulated LncRNA FGD5‐AS1 and downregulated miR‐497‐5p were observed in LSCC tissues and cells, and LncRNA FGD5‐AS1 ablation inhibited cancer progression. Also, LncRNA FGD5‐AS1 overexpression increased cisplatin‐resistance in LSCC by modulating the miR‐497‐5p/SEPT2 axis. Collectively, we conclude that targeting the LncRNA FGD5‐AS1/miR‐497‐5p/SEPT2 signaling cascade may be an alternative strategy to treat LSCC in the clinic.
“…As one of the common malignancies in the head and neck, laryngeal squamous cell carcinoma (LSCC) brings a huge health burden for patients worldwide 1,2 . The risk factors that contribute to the onset, initiation, and development of LSCC are complicated and include smoking, alcohol drinking, environmental stress, radioactivity, viral infection, and microelement deficiency 3–6 .…”
Aberrant expression or mutation of the Septin gene family is closely associated with cancer progression, and septin 2 (SEPT2) exerts its tumor‐promoting effects in multiple cancers, but its role in regulating laryngeal squamous cell carcinoma (LSCC) progression and drug resistance has not been investigated. Based on the published data, the present study identified that SEPT2 promoted cancer progression and increased cisplatin‐resistance in LSCC, and a novel LncRNA FGD5‐AS1/miR‐497‐5p axis was crucial for this process. Mechanistically, SEPT2 tended to be enriched in LSCC tissues and cells, and knock‐down of SEPT2 inhibited cell proliferation, viability, migration, and tumorigenesis in LSCC cells in vitro and in vivo. Aside from that, SEPT2 overexpression increased cisplatin resistance in LSCC cells. Next, by conducting the dual‐luciferase reporter gene system assay, we identified that the LncRNA FGD5‐AS1/miR‐497‐5p axis regulated SEPT2 in LSCC. Specifically, LncRNA FGD5‐AS1 sponged miR‐497‐5p to upregulate SEPT2 in LSCC cells in a competing endogenous RNA (ceRNA) mechanisms‐dependent manner. Interestingly, upregulated LncRNA FGD5‐AS1 and downregulated miR‐497‐5p were observed in LSCC tissues and cells, and LncRNA FGD5‐AS1 ablation inhibited cancer progression. Also, LncRNA FGD5‐AS1 overexpression increased cisplatin‐resistance in LSCC by modulating the miR‐497‐5p/SEPT2 axis. Collectively, we conclude that targeting the LncRNA FGD5‐AS1/miR‐497‐5p/SEPT2 signaling cascade may be an alternative strategy to treat LSCC in the clinic.
“…This approach is often used to improve the success rate of surgery and potentially minimize the extent of tissue removal during the procedure. Surgical excision was considered the first line of treatment in other reports with adjuvant chemo- or radiotherapy [ 18 ]. Fig.…”
“…We presented one case of Basaloid squamous cell carcinoma (BSCC) with sarcomatous transformation and osteosarcoma in our series (case 2). Laryngeal tumors composed of BSCC and spindle cells are exceedingly rare; few cases were reported in literature and only one case presented osteosarcomatous differentiation [11,12]. It is characterized by basal palisading, high nuclear to cytoplasmic ration and central necrosis, consistent with a basaloid morphology [13].…”
Spindle cell squamous cell carcinoma (SCSCC) is a rare malignant tumor, which involves both squamous
cell carcinoma and sarcomatoid proliferation. It remains uncommon in the larynx and represents only 1 %
of SCSCC of the head and neck. This tumor still poses diagnostic and therapeutic challenges. In the present
report, three cases of laryngeal SCSCC were investigated; their clinical, pathological findings, treatment
and outcomes are described. The patients were smoker men aged 50, 66 and 66 years old respectively.
Dysphonia was the mean symptom. The tumor involves the vocal cord in all cases. The patient underwent
laryngectomy with bilateral neck dissection. Histological examination confirmed the diagnostic of SCSCC.
One case showed basaloid squamous cell carcinoma with sarcomatous transformation and osteosarcoma.
Immunohistochemical analysis performed in one patient was positive for vimentin, SMA, PS100, focally
for EMA and negative for keratin and P63.One case presented lymph nodes metastases and an adjuvant
radiotherapy was preconised for this patient. All patients were well controlled after treatment and there was
no recurrence during the following up.
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