Larger dispersion of INa in female dog ventricle as a mechanism for gender-specific incidence of cardiac arrhythmias

Barajas-Martínez, Héctor; Haufe, Volker; Chamberland, Caroline; Roy, Marie-Josée Blais; Fecteau, Marie Hélène; Cordeiro, Jonathan M.; Dumaine, Robert

doi:10.1093/cvr/cvn255

Cited by 47 publications

(30 citation statements)

References 43 publications

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“…23 This together with the fact that I Na is smaller in female vs male ventricular myocytes may explain why AVNRT is more common in female patients in general and in patients with concealed BrS. 24 …”

Section: Brs and Female Sexmentioning

confidence: 99%

High prevalence of concealed Brugada syndrome in patients with atrioventricular nodal reentrant tachycardia

Hasdemir¹,

Payzın²,

Kocabaş³

et al. 2015

Heart Rhythm

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Section: Brs and Female Sexmentioning

confidence: 99%

High prevalence of concealed Brugada syndrome in patients with atrioventricular nodal reentrant tachycardia

Hasdemir¹,

Payzın²,

Kocabaş³

et al. 2015

Heart Rhythm

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“…It has also recently been reported that testosterone modulates sodium current dispersion in a canine heart model. 9 In addition, there is evidence that steroid hormones have rapid physiological responses through a non-genomic pathway. Consequently, there is probably a complex interplay of gonadal steroids, genetic and ionic influences.…”

Section: Article P 63mentioning

confidence: 99%

Brugada Phenotype and Prostate Cancer

Kusano

2009

Circ J

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“…Lowe et al reported that INa,L magnitude is higher in female mice compared to males and concluded that this difference contributes to higher arrhythmia susceptibility of females. The increased susceptibility of females to arrhythmias may be further compounded by reduced repolarization reserve and larger intramyocardial inhomogeneity of calcium and potassium currents in females [113][114][115][116][117][118][119][120].…”

Section: Transmural Heterogeneity Of I Nalmentioning

confidence: 99%

An Emerging Antiarrhythmic Target: Late Sodium Current

Bányász

Szentandrássy²,

Magyar³

et al. 2014

CPD

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The cardiac late sodium current (INa,L) has been in the focus of research in the last decade. The first reports on the sustained component of voltage activated sodium current dates back to the early seventies, but early observations interpreted this tiny current as a product of a few channels that fail to inactivate having neither physiologic nor pathologic implications. INa,L has emerged recently as a potentially major arrhythmogenic mechanism in various heart diseases attracting the attention of both clinicians and researchers. Research activity on INa,L has exponentially increased since Ranolazine, an FDA-approved antianginal drug was shown to successfully suppress cardiac arrhythmias by inhibiting INa,L. This review aims to conclude a series of papers concerned with physiology and regulation of cardiac late sodium current. Focusing on some recent development of the field we discuss here critical evidences implicating INa,L as a potential target for treating myocardial dysfunction and cardiac arrhythmias.

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Larger dispersion of INa in female dog ventricle as a mechanism for gender-specific incidence of cardiac arrhythmias

Cited by 47 publications

References 43 publications

High prevalence of concealed Brugada syndrome in patients with atrioventricular nodal reentrant tachycardia

High prevalence of concealed Brugada syndrome in patients with atrioventricular nodal reentrant tachycardia

Brugada Phenotype and Prostate Cancer

An Emerging Antiarrhythmic Target: Late Sodium Current

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