Large-scale collection of circulating haematopoietic progenitors in cancer patients treated with high-dose cyclophosphamide and recombinant human GM-CSF

Case report: Pulse cyclophosphamide for treatment of multi-agent-refractory hepatic graft-versus-host disease

“…As a salvage therapy, pulse cyclophosphamide was administered as a one-time pulse dose. This approach is backed by research indicating that even a high dose of cyclophosphamide up to 7,000 mg/m 2 does not cause irreversible marrow damage ( 14 ). Cyclophosphamide’s unique pharmacological properties result in maximal immunosuppression without myeloablation.…”

Case report: Pulse cyclophosphamide for treatment of multi-agent-refractory hepatic graft-versus-host disease

“…As a salvage therapy, pulse cyclophosphamide was administered as a one-time pulse dose. This approach is backed by research indicating that even a high dose of cyclophosphamide up to 7,000 mg/m 2 does not cause irreversible marrow damage ( 14 ). Cyclophosphamide’s unique pharmacological properties result in maximal immunosuppression without myeloablation.…”

Febrile Neutropenia in Children: Etiologies, Outcomes, and Risk Factors with Prolonged Fever

“…We found that FN episodes among patients receiving G-CSF at the time of presentation were more likely to develop PFN though this finding was not significant in multivariable analysis. It has been previously reported that G-CSF may cause drug fever or fever without source [21], and because most autologous SCT regimens require G-CSF by protocol, this may be a confounder in the strong association of autologous SCT with risk of PFN [22,23].…”

Successful treatment with pulse cyclophosphamide of a steroid‐refractory hepatitic variant of liver acute graft‐vs.‐host disease in a child

“…It has been reported that a high dose of Cy up to 7000 mg/m 2 does not cause irreversible marrow damage from the experience of autologous stem cell collection (18). The reason that high‐dose Cy is not particularly toxic for hematopoietic stem cells may relate to the fact that they express high levels of the detoxifying enzyme aldehyde dehydrogenase (19).…”

Case report: Pulse cyclophosphamide for treatment of multi-agent-refractory hepatic graft-versus-host disease

“…As a salvage therapy, pulse cyclophosphamide was administered as a one-time pulse dose. This approach is backed by research indicating that even a high dose of cyclophosphamide up to 7,000 mg/m 2 does not cause irreversible marrow damage ( 14 ). Cyclophosphamide’s unique pharmacological properties result in maximal immunosuppression without myeloablation.…”

Febrile Neutropenia in Children: Etiologies, Outcomes, and Risk Factors with Prolonged Fever

“…We found that FN episodes among patients receiving G-CSF at the time of presentation were more likely to develop PFN though this finding was not significant in multivariable analysis. It has been previously reported that G-CSF may cause drug fever or fever without source [21], and because most autologous SCT regimens require G-CSF by protocol, this may be a confounder in the strong association of autologous SCT with risk of PFN [22,23].…”

Successful treatment with pulse cyclophosphamide of a steroid‐refractory hepatitic variant of liver acute graft‐vs.‐host disease in a child

“…It has been reported that a high dose of Cy up to 7000 mg/m 2 does not cause irreversible marrow damage from the experience of autologous stem cell collection (18). The reason that high‐dose Cy is not particularly toxic for hematopoietic stem cells may relate to the fact that they express high levels of the detoxifying enzyme aldehyde dehydrogenase (19).…”

Case report: Pulse cyclophosphamide for treatment of multi-agent-refractory hepatic graft-versus-host disease

“…As a salvage therapy, pulse cyclophosphamide was administered as a one-time pulse dose. This approach is backed by research indicating that even a high dose of cyclophosphamide up to 7,000 mg/m 2 does not cause irreversible marrow damage ( 14 ). Cyclophosphamide’s unique pharmacological properties result in maximal immunosuppression without myeloablation.…”

Febrile Neutropenia in Children: Etiologies, Outcomes, and Risk Factors with Prolonged Fever

“…We found that FN episodes among patients receiving G-CSF at the time of presentation were more likely to develop PFN though this finding was not significant in multivariable analysis. It has been previously reported that G-CSF may cause drug fever or fever without source [21], and because most autologous SCT regimens require G-CSF by protocol, this may be a confounder in the strong association of autologous SCT with risk of PFN [22,23].…”

Successful treatment with pulse cyclophosphamide of a steroid‐refractory hepatitic variant of liver acute graft‐vs.‐host disease in a child

“…It has been reported that a high dose of Cy up to 7000 mg/m 2 does not cause irreversible marrow damage from the experience of autologous stem cell collection (18). The reason that high‐dose Cy is not particularly toxic for hematopoietic stem cells may relate to the fact that they express high levels of the detoxifying enzyme aldehyde dehydrogenase (19).…”