Abstract. This paper uses the method of incremental dynamic analysis (IDA), by reading the control section concrete piers and steel strain calculation termination conditions, according to the existing specification design of high speed railway bridge, with the Beijing-shanghai high-speed railway and a large span 40 m + 64 m + 40 m continuous girder bridge as the research object, under severe earthquake, and on the elastic-plastic seismic response of nonlinear computation. The example analysis results can provide reference for seismic design of similar Bridges.