2001
DOI: 10.1016/s1072-7515(01)01010-9
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Laparoscopic Simultaneous Nephrectomy and Distal Pancreatectomy From A Live Donor

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Cited by 68 publications
(29 citation statements)
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“…If maximal transduction efficiency can be achieved in this way, it could even be possible to reverse diabetes with islets isolated from only a portion of the pancreas. The distal pancreas from living donors has been used successfully as a segmental vascularised graft, and recently the donor procedure has been reported using a minimally invasive approach [19,20]. Thus, the consideration of live donors as a source of islets to treat Type 1 diabetes is not unreasonable if the efficiency of islet function and engraftment can be improved.…”
Section: Discussionmentioning
confidence: 99%
“…If maximal transduction efficiency can be achieved in this way, it could even be possible to reverse diabetes with islets isolated from only a portion of the pancreas. The distal pancreas from living donors has been used successfully as a segmental vascularised graft, and recently the donor procedure has been reported using a minimally invasive approach [19,20]. Thus, the consideration of live donors as a source of islets to treat Type 1 diabetes is not unreasonable if the efficiency of islet function and engraftment can be improved.…”
Section: Discussionmentioning
confidence: 99%
“…Since inferior survival rates have been associated with some of these variables, careful assessment on a case-by-case basis is required for safe utilization of pancreata from 'marginal donors' (9)(10)(11)(12). Other alternatives to expand the pancreatic donor pool include the use of living donors and the use of organs donated after cardiac death (DCD) (13,14).…”
Section: Introductionmentioning
confidence: 99%
“…The authors speculate that Ad-Ins-vector delivery by vascular perfusion of the pancreas, would achieve maximal transgene expression in nearly all islet endocrine cells making it possible to reverse diabetes with islets isolated from only a portion of the perfused pancreas. The consideration of live donors as a source of islets is not unreasonable since laparoscopic-assisted distal pancreatectomy and nephrectomy has been performed successfully in three living donors since December 2007 with minimal peri-operative mortality and acceptable morbidity and the distal pancreas has been used successfully as a segmental vascularised graft (Gruessner et al, 2001;Maruyama et al, 2010;Tan et al, 2005). The uneventful postoperative course and normal functioning of the grafts indicate the technique to be minimally invasive and safe, making the consideration of live related donors for providing islet tissue supply a reasonable solution to the problem of organ shortage until other strategies such as stem-cell derivation of -cells or xenogeneic sources of islet tissue can be refined.…”
Section: The Role Of Gene Therapy In Enhancing Islet Functionmentioning
confidence: 99%