Lanthanides in the Soil: Routes of Entry, Content, Effect on Plants, and Genotoxicity (a Review)

Kotelnikova, Anna; Rogova, Olga B.; Stolbova, V. V.

doi:10.1134/s1064229321010051

Cited by 34 publications

(15 citation statements)

References 112 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Concentrations of Ln in the phyllosphere range from 0.7 μg/g dry weight to 7 μg/g dry weight, but bioavailable Ln concentrations are likely far less. 17,19 In most soil environments Ln are found in highly insoluble oxide and phosphate forms, usually in minerals and ores such as monazite and bastnäsite. 20 Despite this, most work done in a laboratory setting has used soluble chloride salts to understand Ln biology.…”

Section: Mainmentioning

confidence: 99%

Discovery and characterization of the first known biological lanthanide chelator

Zytnick¹,

Good²,

Barber³

et al. 2022

Preprint

View full text Add to dashboard Cite

While lanthanide-dependent metabolism is widespread in nature and has been proven to drive one-carbon metabolism in bacteria, details about the machinery necessary to sense, sequester, and traffic lanthanides (Ln) remain unknown. This gap in knowledge is in part because nearly all bacterial growth studies with Ln to date have used soluble chloride salts, compounds that do not reflect the insoluble Ln sources common in the natural environment. Here, we describe the changes in the metabolic machinery of Methylorubrum extorquens AM1 in response to poorly soluble Nd2O3, including 4-fold increases in orphan pqqA genes and the Ln-dependent ADHs xoxF1 and exaF compared to growth with soluble NdCl3. We report the first description of a Ln-chelator biosynthetic gene cluster, encoded by META1p4129 through META1p4138 that we named the Lanthanide Chelation Cluster (LCC). The LCC encodes a TonB dependent receptor and NRPS biosynthetic enzymes and is predicted to produce a metal-chelating molecule. As some LCC protein sequences share similarity to biosynthetic enzymes producing the Fe-chelating siderophore aerobactin, the capacity of aerobactin for binding Ln was tested. It was found that while aerobactin can bind lanthanum (La), neodymium (Nd) and lutetium (Lu) at physiological pH, providing only exogenous aerobactin did not affect growth rate or yield. The LCC was highly upregulated when M. extorquens AM1 was grown using Nd2O3 and expression in trans enabled an increase of Nd bioaccumulation by over 50%. Expression of the LCC in trans did not affect iron bioaccumulation, providing further evidence that its product is a novel Ln-chelator. Finally, expression of the LCC in trans increased Nd, dysprosium (Dy), and praseodymium (Pr) bioaccumulation from the complex Ln source NdFeB magnet swarf by over 60%, opening new strategies for sustainable recovery of these critical Rare Earth Elements.

show abstract

Section: Mainmentioning

confidence: 99%

Discovery and characterization of the first known biological lanthanide chelator

Zytnick¹,

Good²,

Barber³

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…We considered genes with changes in the expression above |0.58| log 2 FC (fold change; a log 2 FC > |0.58| is equivalent to gene expression changes > 50%), expression values higher than 4 log 2 CPM (counts per million), and false-discovery rate (FDR)-adjusted p-values < 0.05 as differentially expressed ( Figure 4A , Table S4-13 ). We determined differentially expressed genes (DEGs) for a total of 10 different comparisons: (1) La vs. Er, (2) Nd vs. Er, (3) Mix vs. Er, (4) La vs. None, (5) Nd vs. none, (6) Mix vs. none, (7) Nd vs. La, (8) Mix vs. La, (9) Mix vs. Nd, and (10) Er vs. None ( Figure 4A ).…”

Section: Resultsmentioning

confidence: 99%

“…Together with the chemically similar elements scandium (Sc) and yttrium (Y), the lanthanides (elements 57-71 [La-Lu], Ln) are commonly known as “rare-earth elements” or more precisely “rare-earth metals” (REM). Based on their electron configuration, which governs interactions with other elements, Ln are grouped into light (La-Eu, Sc; LREM) and heavy (Gd-Yb, Y; HREM) REM (1, 2). Ln are key resources for numerous high-tech applications and in increasing demand for the ongoing green energy transition (3).…”

Section: Introductionmentioning

confidence: 99%

Changes in growth, lanthanide binding, and gene expression inPseudomonas alloputidaKT2440 in response to light and heavy lanthanides

Gorniak,

Bucka,

Nasr

et al. 2024

Preprint

View full text Add to dashboard Cite

Pseudomonas alloputidaKT2440 is a ubiquitous, soil-dwelling bacterium that metabolizes recalcitrant and volatile carbon sources. The latter are utilized by two redundant, Ca- and lanthanide (Ln)-dependent, pyrroloquinoline quinone-dependent alcohol dehydrogenases (PQQ ADH), PedE and PedH, whose expression is regulated by Ln availability.P. alloputidaKT2440 is the best-studied, non-methylotroph in the context of Ln-utilization. We report the most comprehensive differential gene expression analysis, to date, for any Ln-utilizing microbe. Combined with microfluidic cultivation and single-cell elemental analysis, we studied the impact of light and heavy Ln when growingP. alloputidaKT2440 with 2-phenylethanol as the carbon and energy source. Light Ln (La, Ce, Nd) and a mixture of light and heavy Ln (La, Ce, Nd, Dy, Ho, Er, Yb) had a positive effect on growth, while supplementation with heavy Ln (Dy, Ho, Er, Yb) exerted fitness costs. These were likely a consequence of mismetallation and oxidative stress. Gene expression analysis showed that the Ln sensing and signaling machinery, the two-component system PedS2R2 and PedH, responds differently to (non-)utilizable Ln. We broadened the understanding of the Ln switch inP. alloputidaKT2440 and could show that it operates as a dimmer switch, modulating the pool of PQQ ADH dependent on Ln availability. Determined quantities of cell-associated Ln suggest a role for Ln beyond alcohol oxidation. The usability of Ln governs the response ofP. alloputidaKT2440 to different Ln elements.

show abstract

“…1,2 At the same time, the widespread use of Ln is leading to increased inputs of these elements into the environment due to mining activities followed by water and air flows from tailing dumps and sites of further processing as well as the use of Ln-containing fertilizers. [3][4][5] A high mobility might cause an increase of Ln concentrations in aquatic and terrestrial ecosystems in the vicinity of entry sites. In fact, diverse exposure scenarios occurring in the environment have led to positive anthropogenic Ln anomalies in the geo-, hydro-and biosphere, e.g.…”

Section: Introductionmentioning

confidence: 99%

How tobacco (Nicotiana tabacum) BY-2 cells cope with Eu(iii) – a microspectroscopic study

Klotzsche,

Vogel,

Sachs

et al. 2023

Analyst

View full text Add to dashboard Cite

show abstract

Lanthanides in the Soil: Routes of Entry, Content, Effect on Plants, and Genotoxicity (a Review)

Cited by 34 publications

References 112 publications

Discovery and characterization of the first known biological lanthanide chelator

Discovery and characterization of the first known biological lanthanide chelator

Changes in growth, lanthanide binding, and gene expression inPseudomonas alloputidaKT2440 in response to light and heavy lanthanides

How tobacco (Nicotiana tabacum) BY-2 cells cope with Eu(iii) – a microspectroscopic study

Contact Info

Product

Resources

About