Langya virus: A newly identified zoonotic henipavirus

Sah, Ranjit; Mohanty, Aroop; Chakraborty, Sandip; Dhama, Kuldeep

doi:10.1002/jmv.28095

Cited by 10 publications

(19 citation statements)

References 10 publications

(9 reference statements)

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“…LayV for the first time was noticed during surveillance testing of individuals with fever and a recent history of animal exposure in eastern part of China [6,9]. It was detected and isolated in a throat swab sample from a 53-year-old woman patient after metagenomic analysis and virus isolation.…”

Section: Langya Virusmentioning

confidence: 99%

“…This new virus is still poorly understood, and the reported cases are likely only the tip of the iceberg, however public health concerns need to be monitored for any future threat [9,12,14,15]. Just 35 persons have contracted the disease since 2018 making it apparent, that there was no connection between any of the cases.…”

Section: Epidemiology and Transmissionmentioning

confidence: 99%

“…To understand the potential impact of the LayV, the existing risk needs to be assessed and potential containment steps to mitigate the same need to be outlined [9,12]. Although scientists claim that the virus's chance of spreading to humans is low, it shares a close relationship with the two others human henipaviruses (Hendra and Nipah viruses) known to cause respiratory illnesses and even death, for instance Nipah, has a 90% mortality rate [5].…”

Section: Epidemiology and Transmissionmentioning

confidence: 99%

“…Those infected with LayV almost universally displayed the symptom of fever along with respiratory symptoms like cough and exhaustion, but no one has died as a result of it [19]. In Shandong and Henan provinces, out of the total 35 cases of LayV infection, it was found that 26 of them manifested symptoms including fever, cough, fatigue, irritability, loss of appetite, headache, muscle pain, nausea, and vomiting [9,34]. All such 26 cases had a high temperature, 54% complained of fatigue, 50% had a cough, and 38% were nauseated.…”

Section: Clinical Symptomsmentioning

confidence: 99%

“…Almost three years after the identification of the novel SARS-CoV-2 virus in China, a new zoonotic virus has been found in the Shandong and Henan provinces, with 35 cases identified so far [6]. This novel phylogenetically distinct Henipavirus strain is known as the Langya Henipavirus or the LayV, and various aspects of this virus and the disease it causes, zoonotic public health concerns and whether it is a virus sitting on tip of the iceberg for causing any major public health concerns need to be investigated with further explorative researches and disease surveillance findings [7][8][9][10][11][12][13][14][15]. There are several Henipaviruses already identified among them Hendra virus and Nipah virus are two of the already known henipaviruses; the other kinds include cedar virus, mojiang virus, and the ghanaian bat virus, which are all considerably less virulent.…”

Section: Introductionmentioning

confidence: 99%

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‘Langya’ Virus, A Zoonotic Henipavirus Recently Emerged in China, Public Health Concerns, and Counteracting Prevention and Control Measures- An Update

Sah¹,

Shah²,

Rao³

et al. 2023

Preprint

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The risk of 'zoonotic spillovers,' or the transmission of viruses from animals to humans, has been raised by climate change and the devastation of nature, as infectious disease experts have long warned. Even as the world works to stop the spread of the currently unfolding pandemic of coronavirus disease 2019 (COVID-19) and the breakout of monkeypox virus (MPXV), a new animal virus, the Langya henipavirus (LayV), has been discovered in humans in Eastern China. The scientists say there is little danger of the virus spreading among humans, but it shares genetic material with Hendra virus and Nipah virus, two other henipaviruses that infect humans and cause life-threatening respiratory diseases. Humans infected with LayV can expect to experience high body temperature, cough, weariness, poor appetite, muscle discomfort, myalgia, nausea and vomiting. It is likely that the virus will spread from animals to humans. Currently, the health authorities of Taiwan and other health organizations are tracking the progress of the ailment to ensure it does not reach humans. Researchers have examined 25 species of small wild animals for presence of the virus, and so far, shrews are the only ones that have tested positive for the virus's RNA. Based on these results, shrews are a possible candidate for the virus's natural reservoir. Too far, no therapies or vaccines have been developed and licensed for henipaviruses like the LayV. When other therapies fail to alleviate viral infections, ribavirin may be the next best thing. The need for novel vaccinations against the LayV infection and the timely delivery of these vaccines to areas at high epidemiological risk is real. To lessen the likelihood of a health calamity being caused by this newly developing virus, it is crucial to conduct active surveillance in a transparent and globally collaborative manner. The questions that have not been answered yet require additional study.

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Section: Langya Virusmentioning

confidence: 99%

Section: Epidemiology and Transmissionmentioning

confidence: 99%

Section: Epidemiology and Transmissionmentioning

confidence: 99%

Section: Clinical Symptomsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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‘Langya’ Virus, A Zoonotic Henipavirus Recently Emerged in China, Public Health Concerns, and Counteracting Prevention and Control Measures- An Update

Sah¹,

Shah²,

Rao³

et al. 2023

Preprint

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A comprehensive review of Langya virus and framework for future zoonotic disease control

Thien,

Tran,

Uyen

et al. 2024

Reviews in Medical Virology

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First reported in August 2022, the Langya virus (LayV) has emerged as a potential global health threat in the post‐COVID‐19 era. Preliminary reports show that 35 patients near Shandong and Henan, China experienced a febrile acute LayV infection. We conducted this review following the PRISMA protocol to synthesise current knowledge on LayV's characteristics in terms of molecular, clinical, and public health perspectives. This virus belongs to the Paramyxoviridae family and carries a non‐segmented, single‐stranded negative‐sense RNA genome. Shrews may be the natural reservoir of the virus. Clinical symptoms range from mild flu‐like symptoms to severe manifestations involving pneumonia, haematological disorders, and organ dysfunction. Diagnostic methods include PCR and ELISA assays. Despite the absence of established treatments, antiviral drugs such as ribavirin and chloroquine may be useful in some cases. In light of prevention, a comprehensive approach that emphasises multidisciplinary collaboration is crucial for early surveillance and response. Urgent global efforts are needed for vaccine development and preparedness against this potential pandemic threat. As the viral dynamics remain uncertain, a proactive approach is vital to mitigate the impact of not only LayV but also future threats on a large scale in long term.

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Development and evaluation of a quadruple real-time fluorescence-based quantitative reverse transcription polymerase chain reaction assay for detecting Langya, Mojiang, Nipah, and Cedar viruses

He,

Ma,

Wang

et al. 2024

Biosafety and Health

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Langya virus: A newly identified zoonotic henipavirus

Abstract: To the Editor, Very recently, another plausible threat from the world of zoonotic viruses became the hot topic of the news when a new virus namely Langya virus (LayV), a Henipavirus (HNV), was reported to be

Cited by 10 publications

References 10 publications

‘Langya’ Virus, A Zoonotic Henipavirus Recently Emerged in China, Public Health Concerns, and Counteracting Prevention and Control Measures- An Update

‘Langya’ Virus, A Zoonotic Henipavirus Recently Emerged in China, Public Health Concerns, and Counteracting Prevention and Control Measures- An Update

A comprehensive review of Langya virus and framework for future zoonotic disease control

Development and evaluation of a quadruple real-time fluorescence-based quantitative reverse transcription polymerase chain reaction assay for detecting Langya, Mojiang, Nipah, and Cedar viruses

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