1971
DOI: 10.1001/archderm.104.2.148
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Langerhans' cell granule. An endocytotic organelle

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Cited by 23 publications
(11 citation statements)
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“…Two opposing theories have been proposed as to their function. The first suggests that BGs could function as alternative endocytotic structures, specific to LCs (Tarnowski and Hashimoto, 1967;Hashimoto, 1971;Ishii et al, 1984;Takahashi and Hashimoto, 1985;Takigawa et al, 1985;Bartosik, 1992). However, in our hands and under physiological conditions, BGs appended to the cell surface were an exceptional finding, as previously reported by Wolff (1972) and Stö ssel et al (1990).…”
Section: Discussionsupporting
confidence: 76%
“…Two opposing theories have been proposed as to their function. The first suggests that BGs could function as alternative endocytotic structures, specific to LCs (Tarnowski and Hashimoto, 1967;Hashimoto, 1971;Ishii et al, 1984;Takahashi and Hashimoto, 1985;Takigawa et al, 1985;Bartosik, 1992). However, in our hands and under physiological conditions, BGs appended to the cell surface were an exceptional finding, as previously reported by Wolff (1972) and Stö ssel et al (1990).…”
Section: Discussionsupporting
confidence: 76%
“…LCs remain below the TJ barrier in the steady state. In a previous electron microscopic study of LCs, langerin accumulation and Birbeck granule formation were observed on their cell body surface, 44 suggesting that LCs in the steady state are capable of taking up antigens from their cell bodies that exist below the TJ barrier. Studies in mice have shown that SC barrier damage induces activation of LCs, with dendrite penetration through TJs and formation of TJs between keratinocytes and dendrites, and that langerin accumulates markedly at the tips of their dendrites, with Birbeck granule formation above the TJ barrier.…”
Section: Discussionmentioning
confidence: 86%
“…Our present data demonstrate that langerin is essential for this function, i.e., that no molecular redundancy exists for inducing the development of BG. BG have been described as a component of the endocytic pathway (28,66) and implicated in the processing of antigenic molecules (63). Langerin is internalized into BG VOL.…”
Section: Discussionmentioning
confidence: 99%