Lamotrigine add-on therapy for drug-resistant focal epilepsy

Psychobehavioural and Cognitive Adverse Events of Anti-Seizure Medications for the Treatment of Developmental and Epileptic Encephalopathies

“…In studies comparing the rate of PBAEs across 18 ASMs in adults [ 36 ] and in children [ 37 ] with epilepsy (mainly with DRE), LTG, one of the most frequently used ASMs, had one of the lowest rates of PBAEs and discontinuations because of PBAEs (Table S1 of the ESM). The good PBAE profile of LTG is in line with other studies [ 131 , 214 , 215 ], including the recent Cochrane systematic reviews of LTG studies in drug-resistant focal seizures and drug-resistant generalised tonic-clonic seizures where no PBAEs were among the most frequently reported (Table S1 of the ESM) [ 213 , 216 ]. Of note, LTG also acts as a mood stabiliser and is indicated for depression in patients with bipolar disorder [ 210 , 211 ].…”

Psychobehavioural and Cognitive Adverse Events of Anti-Seizure Medications for the Treatment of Developmental and Epileptic Encephalopathies

“…In studies comparing the rate of PBAEs across 18 ASMs in adults [ 36 ] and in children [ 37 ] with epilepsy (mainly with DRE), LTG, one of the most frequently used ASMs, had one of the lowest rates of PBAEs and discontinuations because of PBAEs (Table S1 of the ESM). The good PBAE profile of LTG is in line with other studies [ 131 , 214 , 215 ], including the recent Cochrane systematic reviews of LTG studies in drug-resistant focal seizures and drug-resistant generalised tonic-clonic seizures where no PBAEs were among the most frequently reported (Table S1 of the ESM) [ 213 , 216 ]. Of note, LTG also acts as a mood stabiliser and is indicated for depression in patients with bipolar disorder [ 210 , 211 ].…”

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“…In a review of prior randomized controlled drug trials, the most frequent adverse events related to lamotrigine use were ataxia, nausea, diplopia and dizziness. The relative risk of diplopia was the highest amongthe adverse events at 3.79, while the relative risk of ataxia was 3.34 [19]. In this review, ataxia developed in 15% of patients as compared to only 4.5% in placebo groups [19].…”

“…The relative risk of diplopia was the highest amongthe adverse events at 3.79, while the relative risk of ataxia was 3.34 [19]. In this review, ataxia developed in 15% of patients as compared to only 4.5% in placebo groups [19].…”

Variability vs Phenotype: multimodal analysis of Dravet Syndrome Brain Organoids powered by Deep Learning

“…Unfortunately, to date, only a few randomized controlled trials of new drugs have been performed 31,37 . Not even common antiseizures sodium channel antagonists drugs, such as lamotrigine or phenytoin, have been systematically analysed in DS, resulting in uncontrolled seizures 38 . In this study, we provide a proof-of-concept that the ImPhenet algorithm can be leveraged to evaluate in vitro the toxic potential of antiseizure drugs.…”

Psychobehavioural and Cognitive Adverse Events of Anti-Seizure Medications for the Treatment of Developmental and Epileptic Encephalopathies

“…In studies comparing the rate of PBAEs across 18 ASMs in adults [ 36 ] and in children [ 37 ] with epilepsy (mainly with DRE), LTG, one of the most frequently used ASMs, had one of the lowest rates of PBAEs and discontinuations because of PBAEs (Table S1 of the ESM). The good PBAE profile of LTG is in line with other studies [ 131 , 214 , 215 ], including the recent Cochrane systematic reviews of LTG studies in drug-resistant focal seizures and drug-resistant generalised tonic-clonic seizures where no PBAEs were among the most frequently reported (Table S1 of the ESM) [ 213 , 216 ]. Of note, LTG also acts as a mood stabiliser and is indicated for depression in patients with bipolar disorder [ 210 , 211 ].…”

Untitled

“…In a review of prior randomized controlled drug trials, the most frequent adverse events related to lamotrigine use were ataxia, nausea, diplopia and dizziness. The relative risk of diplopia was the highest amongthe adverse events at 3.79, while the relative risk of ataxia was 3.34 [19]. In this review, ataxia developed in 15% of patients as compared to only 4.5% in placebo groups [19].…”

“…The relative risk of diplopia was the highest amongthe adverse events at 3.79, while the relative risk of ataxia was 3.34 [19]. In this review, ataxia developed in 15% of patients as compared to only 4.5% in placebo groups [19].…”

Variability vs Phenotype: multimodal analysis of Dravet Syndrome Brain Organoids powered by Deep Learning

“…Unfortunately, to date, only a few randomized controlled trials of new drugs have been performed 31,37 . Not even common antiseizures sodium channel antagonists drugs, such as lamotrigine or phenytoin, have been systematically analysed in DS, resulting in uncontrolled seizures 38 . In this study, we provide a proof-of-concept that the ImPhenet algorithm can be leveraged to evaluate in vitro the toxic potential of antiseizure drugs.…”

Psychobehavioural and Cognitive Adverse Events of Anti-Seizure Medications for the Treatment of Developmental and Epileptic Encephalopathies

“…In studies comparing the rate of PBAEs across 18 ASMs in adults [ 36 ] and in children [ 37 ] with epilepsy (mainly with DRE), LTG, one of the most frequently used ASMs, had one of the lowest rates of PBAEs and discontinuations because of PBAEs (Table S1 of the ESM). The good PBAE profile of LTG is in line with other studies [ 131 , 214 , 215 ], including the recent Cochrane systematic reviews of LTG studies in drug-resistant focal seizures and drug-resistant generalised tonic-clonic seizures where no PBAEs were among the most frequently reported (Table S1 of the ESM) [ 213 , 216 ]. Of note, LTG also acts as a mood stabiliser and is indicated for depression in patients with bipolar disorder [ 210 , 211 ].…”

Untitled

“…In a review of prior randomized controlled drug trials, the most frequent adverse events related to lamotrigine use were ataxia, nausea, diplopia and dizziness. The relative risk of diplopia was the highest amongthe adverse events at 3.79, while the relative risk of ataxia was 3.34 [19]. In this review, ataxia developed in 15% of patients as compared to only 4.5% in placebo groups [19].…”

“…The relative risk of diplopia was the highest amongthe adverse events at 3.79, while the relative risk of ataxia was 3.34 [19]. In this review, ataxia developed in 15% of patients as compared to only 4.5% in placebo groups [19].…”

Variability vs Phenotype: multimodal analysis of Dravet Syndrome Brain Organoids powered by Deep Learning

“…Unfortunately, to date, only a few randomized controlled trials of new drugs have been performed 31,37 . Not even common antiseizures sodium channel antagonists drugs, such as lamotrigine or phenytoin, have been systematically analysed in DS, resulting in uncontrolled seizures 38 . In this study, we provide a proof-of-concept that the ImPhenet algorithm can be leveraged to evaluate in vitro the toxic potential of antiseizure drugs.…”