Lamina Cribrosa and Peripapillary Sclera Histomorphometry in Normal and Advanced Glaucomatous Chinese Eyes with Various Axial Length

Abstract

Lamina cribrosa thickness and peripapillary sclera thickness decreased significantly with axial length, in addition to a glaucoma-related thinning of the lamina cribrosa. In non-axially elongated eyes, the peripapillary sclera thickness did not vary significantly between glaucomatous eyes and normal eyes.

Comparison of Lamina Cribrosa Thickness in Normal Tension Glaucoma Patients With Unilateral Visual Field Defect

“…26,27 Many groups hypothesized that IOP-related deformations could cause anterior laminar beam failure, which in turn would transfer the load to adjacent beams, causing a damage cascade that results in glaucomatous optic disc cupping and thinning of the entire lamina cribrosa. 19,[28][29][30][31] In this study, the central locations of the lamina cribrosa in VFaffected eyes were significantly thinner than in the fellow eyes in NTG patients with unilateral VF defect. This study also determined that the normal subject eyes had thicker lamina cribrosa than the VF-unaffected eyes of NTG patients.…”

Central corneal thickness, lamina cribrosa and peripapillary scleral histomorphometry in non-glaucomatous chinese eyes

“…The reproducibility of the technique was assessed in a previous study [7]. Ten randomly selected histological optic disc sections were re-evaluated five times by the same person (RR), who also performed all measurements in the present investigation.…”

The translaminar pressure gradient in sustained zero gravity, idiopathic intracranial hypertension, and glaucoma

“…This dynamic structure acts as a sieve that allows the optic nerve to pass from one pressurized environment to another. The lamina cribrosa is normally 500 lm thick, but in patients who have glaucoma it is thinner and bows posteriorly [17,45,46]. When a pressure difference occurs across the lamina cribrosa, either orthograde or retrograde axoplasmic flow can be slowed or halted and the lamina cribrosa may remodel and bow in the direction of the net forced produced by the difference between IOP and CSFp [18][19][20][21]26].…”