LAMA4 expression is activated by zinc finger E‑box‑binding homeobox�1 and independently predicts poor overall survival in gastric cancer

Wang, Xiangjun; Hou, Qinge; Zhou, Xinling

doi:10.3892/or.2018.6564

Cited by 13 publications

(14 citation statements)

References 28 publications

(35 reference statements)

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“…instance, the laminin alpha 4, beta 3 and gamma 2 have been reported to be tightly linked to the malignancy of gastric cancer [6,7]. The laminin subunit gamma 1 (LAMC1) is an important prognostic factor in human cancers, like hepatocellular carcinoma and endometrial cancer [8,9].…”

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confidence: 99%

LAMC1 is related to the poor prognosis of patients with gastric cancer and facilitates cancer cell malignancies

Han¹,

Jiang²,

Fan³

2021

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Gastric cancer is a common malignancy in the alimentary system. The laminin subunit gamma 1 (LAMC1) is an important oncogene in human cancers. However, how and whether LAMC1 takes part in gastric cancer progression is largely uncertain. This study analyzed the association between clinical factors of patients and LAMC1 expression and explored the influence of LAMC1 silencing on cell proliferation, migration, invasion, the Warburg effect, protein kinase B (AKT) pathway, and mitogen-activated protein kinase (MEK)/extracellular regulated protein kinase (ERK) pathway in gastric cancer cells. Our results showed LAMC1 abundance was enhanced in gastric cancer samples and cells. LAMC1 was related to the clinical stage, tumor depth, lymph node metastasis, and distant metastasis of patients. LAMC1 silencing inhibited cell proliferation, migration, and invasion. Moreover, LAMC1 knockdown suppressed the Warburg effect via decreasing lactate production, lactate dehydrogenase (LDH) activity, and glucose uptake. LAMC1 interference blocked the activation of the AKT and MEK/ERK signaling. Collectively, LAMC1 knockdown constrained ce ll proliferation, migration, invasion, and the Warburg effect in gastric cancer cells via inactivating the AKT and MEK/ERK pathway.

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confidence: 99%

LAMC1 is related to the poor prognosis of patients with gastric cancer and facilitates cancer cell malignancies

Han¹,

Jiang²,

Fan³

2021

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“…We surveyed the literature in an unbiased manner, identifying multiple genes for further assessment based on their known and potential roles in cancer cell migration, invasion, and patient outcome. We selected four candidate genes to analyze potential changes in expression when p120ctn is down-regulated and EGFR is overexpressed – Integrin subunit alpha 1 ( ITGA1 ) 40 – 43 , Laminin subunit alpha 4 ( LAMA4 ) 44 – 46 , RhoC GTPase ( RHOC ) 47 – 51 , and Twist Family BHLH Transcription Factor 2 ( TWIST2 ) 52 – 55 . The identified genes were also previously established to have interactions with EGFR.…”

Section: Resultsmentioning

confidence: 99%

Twist2 is NFkB-responsive when p120-catenin is inactivated and EGFR is overexpressed in esophageal keratinocytes

Lehman

Kidacki

Stairs

2020

Sci Rep

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Esophageal squamous cell carcinoma (ESCC) is among the most aggressive and fatal cancer types. ESCC classically progresses rapidly and frequently causes mortality in four out of five patients within two years of diagnosis. Yet, little is known about the mechanisms that make ESCC so aggressive. In a previous study we demonstrated that p120-catenin (p120ctn) and EGFR, two genes associated with poor prognosis in ESCC, work together to cause invasion. Specifically, inactivation of p120ctn combined with overexpression of EGFR induces a signaling cascade that leads to hyperactivation of NFkB and a resultant aggressive cell type. The purpose of this present study was to identify targets that are responsive to NFkB when p120ctn and EGFR are modified. Using human esophageal keratinocytes, we have identified Twist2 as an NFkB-responsive gene. Interestingly, we found that when NFkB is hyperactivated in cells with EGFR overexpression and p120ctn inactivation, Twist2 is significantly upregulated. Inhibition of NFkB activity results in nearly complete loss of Twist2 expression, suggesting that this potential EMT-inducing gene, is a responsive target of NFkB. There exists a paucity of research on Twist2 in any cancer type; as such, these findings are important in ESCC as well as in other cancer types.

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“…Of these 18 genes obtained from TCGA, four genes (FN1, 29,30 LAMA4, 31 RELN 32 and ITGB1 33,34 ) have been reported to be involved in GC pathogenesis or related to patient prognosis. The remaining 14 genes have not been reported to be involved in the prognosis of GC and could be used as potential biomarker.…”

Section: Discussionmentioning

confidence: 99%

Mining TCGA database for genes of prognostic value in gastric cancer microenvironment

Lan

Wang

Tian

et al. 2020

J Cellular Molecular Medi

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Gastric cancer (GC) is the sixth most common malignancy and the third leading cause of cancer-related death worldwide. 1 Despite the declining morbidity as well as mortality and the significant advances in the comprehension of aetiology and molecular mechanisms, the burden remains high in Asia, Latin America, and eastern and central part of Europe. 2 Although several treatment approaches are applied including surgery, chemotherapy, radiation therapy and molecular targeted therapies, the long-term outcome of GC patients at advanced stages remains disappointing. 3,4 The tumour microenvironment (TME) refers to the environment in which cancer cells originate and develop. Except for cancer cells, the TME consists of different cell types (stromal cells, immune cells, endothelial cells, etc) and extracellular elements (chemokine, cytokines, hormones, etc). 5,6 Emerging evidence suggests that TME cells (including macrophages, T cells and fibroblasts) all play a vital role in the initiation and progression of GC. 7-11 As two major cell types apart from cancer cells in the TME, stromal cells and immune cells exhibit important role in diagnostic and prognostic evaluation of solid tumours. Stromal cells can receive signals sent by cancer cells and then supply the cancer cells with a variety of growth factors, which are essential for invasive growth and metastasis. 12-17 On the other hand, the immune cells in the TME function in a context-dependent way: tumour-antagonizing effects of T cells in ovarian cancer 18-20 and tumour-promoting effects in colorectal cancer. 21,22 Hence, an overall understanding of stromal cells and immune cells

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LAMA4 expression is activated by zinc finger E‑box‑binding homeobox�1 and independently predicts poor overall survival in gastric cancer

Cited by 13 publications

References 28 publications

LAMC1 is related to the poor prognosis of patients with gastric cancer and facilitates cancer cell malignancies

LAMC1 is related to the poor prognosis of patients with gastric cancer and facilitates cancer cell malignancies

Twist2 is NFkB-responsive when p120-catenin is inactivated and EGFR is overexpressed in esophageal keratinocytes

Mining TCGA database for genes of prognostic value in gastric cancer microenvironment

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