Lag time between onset of symptoms and diagnosis of endometriosis

Santos, Tânia Mara Vieira; Pereira, Ana Maria Gomes; Lopes, Reginaldo Guedes Coelho; Depes, Daniela De Batista

doi:10.1590/s1679-45082012000100009

Cited by 35 publications

(33 citation statements)

References 16 publications

(27 reference statements)

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“…There is usually a large diagnostic delay, reaching 6 or more years, even in large centers [9]. This delay occurs even in patients with deep endometriosis who have more severe disease.…”

Section: Discussionmentioning

confidence: 99%

How to use CA-125 More Effectively in the Diagnosis of Deep Endometriosis?

Raymundo

Oliveira

Soares

et al. 2017

Journal of Minimally Invasive Gynecology

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Deep infiltrative endometriosis (DIE) is a severe form of the disease. The median time interval from the onset of symptoms to diagnosis of endometriosis is around 8 years. In this prospective study patients were divided into two groups: cases (34 DIE patients) and control (20 tubal ligation patients). The main objective of this study was to evaluate the performance of CA-125 measurement in the menstrual and midcycle phases of the cycle, as well as the difference in its levels between the two phases, for the early diagnosis of DIE. Area Under the Curve (AUC) of CA-125 in menstrual phase and of the difference between menstrual and midcycle phases had the best performance (both with AUC = 0.96), followed by CA-125 in the midcycle (AUC = 0.89). The ratio between menstrual and midcycle phases had the worst performance. CA-125 may be useful for the diagnosis of deep endometriosis, especially when both are collected during menstruation and in midcycle. These may help to decrease the long interval until the definitive diagnosis of DIE. Multicentric studies with larger samples should be performed to better evaluate the cost-effectiveness of measuring CA-125 in two different phases of the menstrual cycle.

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“…There is usually a large diagnostic delay, reaching 6 or more years, even in large centers [9]. This delay occurs even in patients with deep endometriosis who have more severe disease.…”

Section: Discussionmentioning

confidence: 99%

How to use CA-125 More Effectively in the Diagnosis of Deep Endometriosis?

Raymundo

Oliveira

Soares

et al. 2017

Journal of Minimally Invasive Gynecology

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“…É consenso na literatura que a dismenorreia é o sintoma mais prevalente nas mulheres com endometriose. 2,21,[23][24][25][26][27][28] A dispareunia foi o segundo sintoma mais relatado em mulheres com endometriose. 2,24,27 No presente estudo, não se fez a diferenciação do tipo de dispareunia, foi vista em alguns artigos apenas a dispareunia de profundidade, o que seria um possível indicativo de doença profunda.…”

Section: Tabela 2 -Sintomas Associados à Endometriose Nas Mulheres Inunclassified

“…2,26 Em relação à dor fora do período menstrual (23,3%), a população específica estudada mostrou menor prevalência quando comparada com a de outros estudos, nos quais se configurou a dor pélvica crônica. 2,24 A associação com a infertilidade e a procura mais precoce por um serviço de reprodução humana poderiam justificar essa diferença, considerando que o tempo de exposição da doença seria menor.…”

Section: Tabela 2 -Sintomas Associados à Endometriose Nas Mulheres Inunclassified

Perfil epidemiológico das pacientes inférteis com endometriose

Oliveira

Musich

Ferreira

et al. 2015

Reprodução & Climatério

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“…As a result, women can suffer for years before receiving a definitive diagnosis and appropriate treatment [124]. As a result, women can suffer for years before receiving a definitive diagnosis and appropriate treatment [124].…”

Section: Diagnostic and Therapeutic Perspectivesmentioning

confidence: 99%

Genetic, epigenetic and stem cell alterations in endometriosis: new insights and potential therapeutic perspectives

2013

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Human endometrium is a highly dynamic tissue, undergoing periodic growth and regression at each menstrual cycle. Endometriosis is a frequent chronic pathological status characterized by endometrial tissue with an ectopic localization, causing pelvic pain and infertility and a variable clinical presentation. In addition, there is well-established evidence that, although endometriosis is considered benign, it is associated with an increased risk of malignant transformation in approximately 1.0% of affected women, with the involvement of multiple pathways of development. Increasing evidence supports a key contribution of different stem/progenitor cell populations not only in the cyclic regeneration of eutopic endometrium, but also in the pathogenesis of at least some types of endometriosis. Evidence has arisen from experiments in animal models of disease through different kinds of assays (including clonogenicity, the label-retaining cell approach, the analysis of undifferentiation markers), as well as from descriptive studies on ectopic and eutopic tissue samples harvested from affected women. Changes in stem cell populations in endometriotic lesions are associated with genetic and epigenetic alterations, including imbalance of miRNA expression, histone and DNA modifications and chromosomal aberrations. The present short review mainly summarizes the latest observations contributing to the current knowledge regarding the presence and the potential contribution of stem/progenitor cells in eutopic endometrium and the aetiology of endometriosis, together with a report of the most recently identified genetic and epigenetic alterations in endometriosis. We also describe the potential advantages of single cell molecular profiling in endometrium and in endometriotic lesions. All these data can have clinical implications and provide a basis for new potential therapeutic applications.

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Lag time between onset of symptoms and diagnosis of endometriosis

Abstract: The lag time between onset of symptoms and diagnosis of endometriosis was shorter, as compared to other national and international evaluations.

Cited by 35 publications

References 16 publications

How to use CA-125 More Effectively in the Diagnosis of Deep Endometriosis?

How to use CA-125 More Effectively in the Diagnosis of Deep Endometriosis?

Perfil epidemiológico das pacientes inférteis com endometriose

Genetic, epigenetic and stem cell alterations in endometriosis: new insights and potential therapeutic perspectives

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