Lacunar Infarcts Defined by Magnetic Resonance Imaging of 3660 Elderly People: The Cardiovascular Health Study

Abstract

In this group of older adults, lacunes defined by MRI are common and associated with factors that likely promote or reflect small-vessel disease. Silent lacunes are also associated with neurologic dysfunction.

Longitudinal changes in brain volumes and cerebrovascular lesions on MRI in patients with manifest arterial disease: The SMART-MR study

“…This finding is in contrast with our cross-sectional findings and the results from a population-based longitudinal study on new brain infarcts, where there were no significant sex differences [2,26]. Additionally, for lacunar infarcts, a cross-sectional study in the general population showed a higher risk for women instead of men [27], while another population-based study did not [28]. These inconsistent findings make it difficult to explain the association of new brain infarcts with male sex.…”

Longitudinal changes in brain volumes and cerebrovascular lesions on MRI in patients with manifest arterial disease: The SMART-MR study

“…This finding is in contrast with our cross-sectional findings and the results from a population-based longitudinal study on new brain infarcts, where there were no significant sex differences [2,26]. Additionally, for lacunar infarcts, a cross-sectional study in the general population showed a higher risk for women instead of men [27], while another population-based study did not [28]. These inconsistent findings make it difficult to explain the association of new brain infarcts with male sex.…”

Risk Factors for Silent Cerebral Infarcts in Subcortical White Matter and Basal Ganglia

“…These associations noted in univariate analyses were likely to be discounted by interaction among factors, especially by correlations with age. Although it has been reported that smoking habit is associated with SCIs in large population-based studies, 19,21 this finding was not replicated in our study. This lack of association may be attributable to the relatively small sample size of our study.…”

Importance of Symptomatic Cerebral Infarcts on Cognitive Performance in Patients with Alzheimer's Disease

“…We did not find a detrimental effect of silent radiological infarcts in AD patients, unlike some studies of non-demented elderly or patients with mild AD (4, 10). Usually, silent infarcts have a smaller volume and are located in non-eloquent areas compared to symptomatic infarcts; therefore, it is difficult to detect minimal changes resulting from minor infarcts, especially in severe or neocortical stage AD.…”

Longitudinal changes in brain volumes and cerebrovascular lesions on MRI in patients with manifest arterial disease: The SMART-MR study

“…This finding is in contrast with our cross-sectional findings and the results from a population-based longitudinal study on new brain infarcts, where there were no significant sex differences [2,26]. Additionally, for lacunar infarcts, a cross-sectional study in the general population showed a higher risk for women instead of men [27], while another population-based study did not [28]. These inconsistent findings make it difficult to explain the association of new brain infarcts with male sex.…”

Risk Factors for Silent Cerebral Infarcts in Subcortical White Matter and Basal Ganglia

“…These associations noted in univariate analyses were likely to be discounted by interaction among factors, especially by correlations with age. Although it has been reported that smoking habit is associated with SCIs in large population-based studies, 19,21 this finding was not replicated in our study. This lack of association may be attributable to the relatively small sample size of our study.…”

Importance of Symptomatic Cerebral Infarcts on Cognitive Performance in Patients with Alzheimer's Disease

“…We did not find a detrimental effect of silent radiological infarcts in AD patients, unlike some studies of non-demented elderly or patients with mild AD (4, 10). Usually, silent infarcts have a smaller volume and are located in non-eloquent areas compared to symptomatic infarcts; therefore, it is difficult to detect minimal changes resulting from minor infarcts, especially in severe or neocortical stage AD.…”

Longitudinal changes in brain volumes and cerebrovascular lesions on MRI in patients with manifest arterial disease: The SMART-MR study

“…This finding is in contrast with our cross-sectional findings and the results from a population-based longitudinal study on new brain infarcts, where there were no significant sex differences [2,26]. Additionally, for lacunar infarcts, a cross-sectional study in the general population showed a higher risk for women instead of men [27], while another population-based study did not [28]. These inconsistent findings make it difficult to explain the association of new brain infarcts with male sex.…”

Risk Factors for Silent Cerebral Infarcts in Subcortical White Matter and Basal Ganglia

“…These associations noted in univariate analyses were likely to be discounted by interaction among factors, especially by correlations with age. Although it has been reported that smoking habit is associated with SCIs in large population-based studies, 19,21 this finding was not replicated in our study. This lack of association may be attributable to the relatively small sample size of our study.…”

Importance of Symptomatic Cerebral Infarcts on Cognitive Performance in Patients with Alzheimer's Disease

“…We did not find a detrimental effect of silent radiological infarcts in AD patients, unlike some studies of non-demented elderly or patients with mild AD (4, 10). Usually, silent infarcts have a smaller volume and are located in non-eloquent areas compared to symptomatic infarcts; therefore, it is difficult to detect minimal changes resulting from minor infarcts, especially in severe or neocortical stage AD.…”