Lactylation: A Novel Post-Translational Modification with Clinical Implications in CNS Diseases
Junyan Liu,
Fengyan Zhao,
Yi Qu
Abstract:Lactate, an important metabolic product, provides energy to neural cells during energy depletion or high demand and acts as a signaling molecule in the central nervous system. Recent studies revealed that lactate-mediated protein lactylation regulates gene transcription and influences cell fate, metabolic processes, inflammation, and immune responses. This review comprehensively examines the regulatory roles and mechanisms of lactylation in neurodevelopment, neuropsychiatric disorders, brain tumors, and cerebr… Show more
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