2022
DOI: 10.3390/ijms23031443
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Abstract: Lactobacillus paracasei KW3110 (KW3110) has anti-inflammatory effects, including the prevention of blue light exposure induced retinal inflammation and ageing-related chronic inflammation in mice. The mechanism involves the promotion of anti-inflammatory cytokine interleukin (IL)-10 production by KW3110, leading to reduced pro-inflammatory cytokine IL-1β production. Although various stress-induced mitochondrial damages are associated with excessive inflammatory responses, the effect of KW3110 on inflammatory-s… Show more

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Cited by 5 publications
(3 citation statements)
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“…We speculated that this was related to the reduction of IL-1, IL-6 and TNF-α levels by LP and the dynamic regulation of CD4+/CD8 + T cell balance. It was consistent with existing studies showing that LP modulated immune response and anti-in ammatory properties [19,[21][22][23][24]. Treatment with LP induced a signi cant improvement in in ammatory status by reducing serum lipopolysaccharide (LPS), free fatty acids (FFA), TNF-α, IL-6, and IL-8 levels, and increasing IL-10 levels [25].…”
Section: Discussionsupporting
confidence: 89%
“…We speculated that this was related to the reduction of IL-1, IL-6 and TNF-α levels by LP and the dynamic regulation of CD4+/CD8 + T cell balance. It was consistent with existing studies showing that LP modulated immune response and anti-in ammatory properties [19,[21][22][23][24]. Treatment with LP induced a signi cant improvement in in ammatory status by reducing serum lipopolysaccharide (LPS), free fatty acids (FFA), TNF-α, IL-6, and IL-8 levels, and increasing IL-10 levels [25].…”
Section: Discussionsupporting
confidence: 89%
“…Lactobacillus strains were reclassified into 25 genera including Lactiplantibacillus, Levilactobacillus, and Lacticaseibacillus according to the new taxonomic conventions [10]. Lactobacillus strains exhibit anticancer [11], antioxidant [12], anti-inflammatory [13], and immuneenhancing [14] properties. To avoid sepsis that could be caused by live cells [11], it is necessary to consider the use of heat-killed Lactobacillus or its metabolites [15].…”
Section: Introductionmentioning
confidence: 99%
“…Lactobacillus strains were reclassi ed into 25 genera including Lactiplantibacillus, Levilactobacillus, and Lacticaseibacillus according to the new taxonomic conventions [10]. Lactobacillus strains exhibit anticancer [11], antioxidant [12], anti-in ammatory [13], and immuneenhancing [14] properties. To avoid sepsis that could be caused by live cells [11], it is necessary to consider the use of heat-killed Lactobacillus or its metabolites [15].…”
Section: Introductionmentioning
confidence: 99%