Lactation protects against myocardial ischemia-reperfusion injury in rats

Shekarforoush, Shahnaz; Safari, Fatemeh

doi:10.1556/036.102.2015.4.4

Cited by 3 publications

(5 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We have demonstrated some preconditioning interventions in previous experiments, reducing infarct size and arrhythmias. 12 , 13 The cardioprotective effect of exercise preconditioning was reported as a reduction in infarct size in previous studies. 14 , 15 Accumulating evidence indicates that both short-term (i.e.…”

Section: Introductionmentioning

confidence: 99%

Whole-Body Vibration Training Increases Myocardial Salvage Against Acute Ischemia in Adult Male Rats

Shekarforoush¹,

Naghii²

2018

Arquivos Brasileiros De Cardiologia

View full text Add to dashboard Cite

BackgroundWhole body vibration training (WBV) is a new training program, which is safe and effective. It can be followed by the public. However, data on the safety and efficacy of vibration on myocardial ischemia reperfusion (IR) injury are lacking.ObjectiveTo examine the effect of WBV on the tolerance of the myocardium to acute IR injury in an experimental rat model.MethodsTwenty-four male Wistar rats were divided into control and vibration groups. Vibration training consisted of vertical sinusoidal whole body vibration for 30 min per day, 6 days per week, for 1 or 3 weeks (WBV1 and WBV3 groups, respectively). All the rats were submitted to myocardial IR injury. Myocardial infarct size and ischemia-induced arrhythmias were assessed. Differences between variables were considered significant when p < 0.05.ResultsNo differences were observed between the groups regarding the baseline hemodynamic parameters. Infarct size was smaller in the experimental group (control, 47 ± 2%; WBV1, 39 ± 2%; WBV3, 37 ± 2%; p < 0.05, vs. control). Vibration produced a significant decrease in the number and duration of ventricular tachycardia (VT) episodes compared to the control value. All ventricular fibrillation (VF) episodes in the vibration groups were self-limited, while 33% of the rats in the control group died due to irreversible VF (p = 0.02).ConclusionThe data showed that vibration training significantly increased cardiac tolerance to IR injury in rats, as evidenced by reduction in the infarct size and cardiac arrhythmias, and by facilitating spontaneous defibrillation.

show abstract

Section: Introductionmentioning

confidence: 99%

Whole-Body Vibration Training Increases Myocardial Salvage Against Acute Ischemia in Adult Male Rats

Shekarforoush¹,

Naghii²

2018

Arquivos Brasileiros De Cardiologia

View full text Add to dashboard Cite

show abstract

“…22,23 The only study indicating cardioprotective effects of lactation against IR injury was recently performed by Shekarforoush and Safari. 17 However, their study did not take into account if the cardioprotection was conferred by the pregnancy alone. In addition, these authors were unable to observe antiarrhythmic effects of lactation during myocardial ischemia.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, these authors were unable to observe antiarrhythmic effects of lactation during myocardial ischemia. 17 In the current study, in vitro Langendorff model was used. Thus, the early-onset cardioprotective effects of lactation can be attributed to the intrinsic characteristics of the heart independent of the complex physiology of lactation.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Effect of Lactation on myocardial vulnerability to ischemic insult in rats

Askari¹,

Imani²,

Sadeghipour³

et al. 2017

Arquivos Brasileiros De Cardiologia

View full text Add to dashboard Cite

BackgroundCardiovascular diseases are the leading cause of mortality and long-term disability worldwide. Various studies have suggested a protective effect of lactation in reducing the risk of cardiovascular diseases.ObjectiveThis study was designed to assess the effects of pregnancy and lactation on the vulnerability of the myocardium to an ischemic insult.MethodsEighteen female rats were randomly divided into three groups: ischemia-reperfusion (IR), in which the hearts of virgin rats underwent IR (n = 6); lactating, in which the rats nursed their pups for 3 weeks and the maternal hearts were then submitted to IR (n = 6); and non-lactating, in which the pups were separated after birth and the maternal hearts were submitted to IR (n = 6). Outcome measures included heart rate (HR), left ventricular developed pressure (LVDP), rate pressure product (RPP), ratio of the infarct size to the area at risk (IS/AAR %), and ventricular arrhythmias - premature ventricular contraction (PVC) and ventricular tachycardia (VT).ResultsThe IS/AAR was markedly decreased in the lactating group when compared with the non-lactating group (13.2 ± 2.5 versus 39.7 ± 3.5, p < 0.001) and the IR group (13.2 ± 2.5 versus 34.0 ± 4.7, p < 0.05). The evaluation of IR-induced ventricular arrhythmias indicated that the number of compound PVCs during ischemia, and the number and duration of VTs during ischemia and in the first 5 minutes of reperfusion in the non-lactating group were significantly (p < 0.05) higher than those in the lactating and IR groups.ConclusionLactation induced early-onset cardioprotective effects, while rats that were not allowed to nurse their pups were more susceptible to myocardial IR injury.

show abstract

“…Although myocardial ischemia and RI are both potent arrhythmogenic stimuli, the mechanisms involved in RA are unclear [11,12]. Oxygen-derived free radicals [13] and cytosolic calcium overload [14] are the 2 main factors of RA, and disturbance of potassium homeostasis is undoubtedly responsible for arrhythmogenesis [15]. In addition, autophagy is an adaptive physiological countermeasure to RA associated with cellular senescence and ischemia/reperfusion [16].…”

Section: Reperfusion Arrhythmias (Ra)mentioning

confidence: 99%

Postconditioning with Nitrates Protects Against Myocardial Reperfusion Injury: A New Use for an Old Pharmacological Agent

2020

View full text Add to dashboard Cite

Early reperfusion remains the key therapy to salvage viable myocardium and must be applied as soon as possible following an acute myocardial infarction (AMI) to attenuate the ischemic insult. However, reperfusion injury may develop following reintroduction of blood and oxygen to vulnerable myocytes, which results in more severe cell death than in the preceding ischemic episode. Ischemic postconditioning (I-PostC) provides a cardioprotective effect in combination with pharmacological agents. Although nitrates have been tested in many experimental and clinical studies of acute AMI to evaluate the cardioprotective effect, few investigations have been focused on nitrates postconditioning in patients undergoing percutaneous coronary intervention (PCI). This review presents the manifestations of myocardial reperfusion injury (RI) and potential mechanisms underlying it, and provides the mechanisms involved in the cardioprotection of I-PostC. We also present a new therapeutic approach to attenuate RI by use of an 'old' agent -nitrates -in AMI patients.

show abstract

Lactation protects against myocardial ischemia-reperfusion injury in rats

Cited by 3 publications

References 38 publications

Whole-Body Vibration Training Increases Myocardial Salvage Against Acute Ischemia in Adult Male Rats

Whole-Body Vibration Training Increases Myocardial Salvage Against Acute Ischemia in Adult Male Rats

Effect of Lactation on myocardial vulnerability to ischemic insult in rats

Postconditioning with Nitrates Protects Against Myocardial Reperfusion Injury: A New Use for an Old Pharmacological Agent

Contact Info

Product

Resources

About