Lactate in Bitches with Pyometra

Volpato, Rodrigo; Rodello, Leandro; Abibe, RB; Lopes, Denivaldo

doi:10.1111/rda.12107

Cited by 5 publications

(5 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Lactate has been used as a parameter for evaluation of inflammation status in dogs ( 12 , 28 , 29 ). Hyperlactatemia is common in emergency and clinical critical care and occurs with evidence of tissue oxygen deficiency and systemic hypoperfusion ( 28 ).…”

Section: Discussionmentioning

confidence: 99%

“…Hyperlactatemia is common in emergency and clinical critical care and occurs with evidence of tissue oxygen deficiency and systemic hypoperfusion ( 28 ). In human medicine, lactate has shown prognostic value in systemic inflammatory response syndrome (SIRS), and recent studies revealed that hypoxia, inflammation, viral infection, and tumors promote the production of lactate, which may act to modulate the immune-inflammatory response ( 29 – 31 ). In accordance with the findings of previous studies, lactate showed a significant difference between group B and the other groups ( 32 , 33 ).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Evaluation of plasma prealbumin as a novel inflammatory biomarker in dogs: a pilot study

Park

Kim

et al. 2023

Front. Vet. Sci.

View full text Add to dashboard Cite

IntroductionPrealbumin (PAB) is a plasma protein synthesized in the hepatic parenchymal cells. PAB has a short half-life (~2 days), and its concentration is affected by changes in transcapillary escape. Measurement of PAB is widely used in hospitalized patients in human medicine due to its decreasing concentration in states of inflammation and malnutrition. However, only a few studies are available in dogs. The aim of this study is to determine whether the plasma PAB concentration decreases in dogs with inflammation and to evaluate the relationship between the plasma PAB concentration and inflammation-related parameters in dogs.MethodsA total of 94 dogs were divided into healthy (n = 33) and diseased (n = 61) groups. These were further divided into group A (n = 24) and group B (n = 37) according to plasma C-reactive protein (CRP) levels. Group A included dogs with a plasma CRP < 10 mg/L, and group B consisted of dogs with a plasma CRP ≥ 10 mg/L. Patient signalment, history, physical examination findings, hematologic and biochemical parameters, various inflammatory markers, and plasma PAB levels were investigated and compared between groups.ResultsThe plasma PAB concentration was found to be lower in group B than in the other groups (p < 0.001), but no statistical difference was found when comparing the control group and group A (p > 0.05). A plasma PAB < 6.3 mg/dL predicted an increased CRP level (10 mg/L or greater) with a sensitivity of 89.5% and a specificity of 86.5%. Receiver operating characteristic curve analysis revealed that the area under the curve for PAB was higher than that for the white blood cell count, neutrophil count, albumin level, lactate level, neutrophil-to-lymphocyte ratio, and neutrophil percentage-to-albumin ratio. In addition, the PAB concentration was significantly negatively correlated with the CRP concentration (r = −0.670, p < 0.001).ConclusionIn conclusion, this is the first study to demonstrate the clinical usefulness of the plasma PAB concentration as an inflammatory marker in dogs. These findings suggest that measuring the plasma PAB concentration along with the CRP concentration may be more useful for evaluating inflammation than measuring CRP alone in canine patients.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Evaluation of plasma prealbumin as a novel inflammatory biomarker in dogs: a pilot study

Park

Kim

et al. 2023

Front. Vet. Sci.

View full text Add to dashboard Cite

show abstract

“…Simultaneously, cells are forced to metabolize glucose anaerobically, which leads to lactate formation. Therefore, elevated lactate is indicative of tissue hypoxia, hypoperfusion and possible damage (Volpato et al, 2012). The increment of lactic acid is evidenced by the duplication of LDH enzyme activities in zinc deficient lambs.…”

Section: Ajavsmentioning

confidence: 99%

Biochemical Alterations in Zinc Deficient Sheep Associated by Hyperlactatemia

El‐Far¹

2013

American Journal of Animal and Veterinary Sciences

View full text Add to dashboard Cite

Blood samples from diseased and clinically healthy Balady sheep of both sexes were collected and subjected for biochemical analysis of serum glucose, fructosamine, lactate, growth hormone, insulin, creatine phosphokinase, Lactate dehydrogenase and aldolase. The obtained results revealed a significant decrease in serum zinc and growth hormone were stated. In contrary, serum glucose and lactate, insulin, CPK, LDH and aldolase were significantly increased statically. While, fructosamine levels were non-significantly increased. From these results can conclude that, in zinc deficient sheep the carbohydrate metabolism is directed toward the anaerobic one accompanied by hyperlactemia which induce muscle cramp and damages leading to increased CPK, LDH and aldolase which appear clinically as enlargement of knee joint, lameness and staggering gait. In addition, growth retardation and wool loss are the main clinical signs of reduction in growth hormone.

show abstract

“…Hyperlactatemia and lactic acidosis occur commonly in veterinary patients and have been extensively studied in clinical disorders such as shock, low cardiac output, acute liver failure, sepsis, neoplasia and seizures (1)(2)(3)(4). It is beyond the scope of this paper to review lactate physiology and pathophysiology but an in-depth discussion on lactate metabolism has been published previously (2).…”

Section: Introductionmentioning

confidence: 99%