Lactase persistence versus decline in human adults: Multifactorial events are involved in down-regulation after weaning

Rossi, Mauro; Maiuri, Luigi; Fusco, MI; Salvati, VM; Fuccio, Antonella; Auricchio, Salvatore; Mantei, Ned; Zecca, Laura; Gloor, SM; Semenza, Giorgio

doi:10.1016/s0016-5085(97)70031-3

Cited by 59 publications

(29 citation statements)

References 6 publications

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“…We therefore measured LPH activity in Caco-2 cells and found that the levels are extremely low compared with human small intestine, which is in accordance with a recent report showing significant differences in gene expression levels in Caco-2 cells compared with cells of the human duodenum (Sun et al, 2002). Differentiated Caco-2 cells contained 0 to 0.12 mU/mg LPH activity in agreement with published data (0.1-0.3 mU/mg even in the "high LPH" PD7 Caco-2 clone) (Chantret et al, 1994), whereas human small intestine from lactose tolerant and intolerant individuals contained 20 to 80 and 2 to 10 mU/mg, respectively (Rossi et al, 1997).…”

Section: Petri Et Alsupporting

confidence: 91%

Absorption/Metabolism of Sulforaphane and Quercetin, and Regulation of Phase Ii Enzymes, in Human Jejunum in Vivo

et al. 2003

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Section: Petri Et Alsupporting

confidence: 91%

Absorption/Metabolism of Sulforaphane and Quercetin, and Regulation of Phase Ii Enzymes, in Human Jejunum in Vivo

et al. 2003

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“…The most obvious hypothesis is that genetic differences in this sequence element cause it to interact differentially with a developmentally regulated trans-acting protein(s). However our recent studies (Poulter et al 2003) and those of Rossi et al (1997) suggest that things are more complicated than this.…”

Section: Congenital Alactasia and Adult Hypolactasiamentioning

confidence: 92%

Genetic influences on carbohydrate digestion

Swallow¹

2003

NRR

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The diversity of the human genome leads to many functional differences between individuals. The present review focuses on genetic variations, both rare and common, that are of relevance to digestion of the sugars and starches that form a major part of human diets, and considers these in relation to the evolution of our species. For example, intolerances of dietary saccharides are not usually life-threatening because symptoms can be avoided by removal of the offending sugar from the diet, and deficiencies of the relevant enzymes are in some cases found at relatively high frequencies in certain populations. This is of evolutionary interest in relation to changes in the human diet, and the lactase-persistence polymorphism, in particular, provides an interesting model. More of the world's adult population are lactase-deficient than have high lactase. The other deficiencies are however much more rare, but the significance of variant alleles at these loci, and also heterozygosity for deficiency alleles, to human nutrition and health is an area that is relatively unexplored.

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“…This genetic modification has been linked to mutations of single bases of DNA control regions, controlling the gene: these mutations differ according to the geographic regions [1]. Man's natural predisposition to hydrolyze lactose in glucose and galactose is reduced approximately in 40% of the general population, this seeming to be mainly associated with intestinal pathologies rather than a genetic deficiency of lactase [2,3].…”

Section: Nutritional Aspectsmentioning

confidence: 99%

Homo sapiens and milk: a valuable food in the past and in the future

Arsenio

Caronna

Cioni

et al. 2010

Mediterr J Nutr Metab

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Milk is a food with a very high biological value, essential in the early stages of life, and has been used to produce ricotta and other cheeses in the Mediterranean area for at least for the last 6,000 years. From a nutritional point of view, in addition to a high water content, milk also contains glucids, proteins of a high biological quality, lipids, vitamins and minerals in highly absorbable forms. In terms of evolution, cholesterol also plays an important role in the activation and propagation of the hedgehog signaling cascade, which is responsible for the differentiation and development of the central nervous system. Finally, the authors analyze its potential as a vector of alimentary supplements, making this food fundamental for human nutrition and the future of Homo sapiens.

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Lactase persistence versus decline in human adults: Multifactorial events are involved in down-regulation after weaning

Cited by 59 publications

References 6 publications

Absorption/Metabolism of Sulforaphane and Quercetin, and Regulation of Phase Ii Enzymes, in Human Jejunum in Vivo

Absorption/Metabolism of Sulforaphane and Quercetin, and Regulation of Phase Ii Enzymes, in Human Jejunum in Vivo

Genetic influences on carbohydrate digestion

Homo sapiens and milk: a valuable food in the past and in the future

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