Lack of genotoxic effects of sucrose acetate isobutyrate (SAIB)

Myhr, B.; Cifone, Maria A.; Ivett, J. L.; Lawlor, Timothy E.; Young, Robert R.

doi:10.1016/s0278-6915(97)80303-1

Cited by 3 publications

(2 citation statements)

References 9 publications

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“…58 An Ames test conducted in S typhimurium cells showed that Sucrose Acetate Isobutyrate was negative for genotoxicity as a mutagen, clastogen, and DNA-damaging agent at concentrations up to 10000 µg/plate (nontoxic; no increase in number of revertants). 59 A mutation assay in Chinese Hamster Ovarian/Hypoxanthine-Guanine Phosphoribosyl Transferase (CHO/HGPRT) cells showed no increase in mutation frequency up to 1000 µg/mL Sucrose Acetate Isobutyrate. A chromosomal aberration assay in CHO cells showed no increase in aberrations up to 2000 µg/mL Sucrose Acetate Isobutyrate.…”

Section: Genotoxicity Studiesmentioning

confidence: 99%

Safety Assessment of Saccharide Esters as Used in Cosmetics

Scott¹,

Bergfeld²,

Belsito³

et al. 2021

Int J Toxicol

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This is a safety assessment of 40 saccharide ester ingredients as used in cosmetics. The saccharide esters are reported to function in cosmetics as emollients, skin-conditioning agents, fragrance ingredients, and emulsion stabilizers. The Expert Panel for Cosmetic Ingredient Safety (Panel) reviewed the relevant data for these ingredients. The Panel concluded that the saccharide esters are safe in cosmetics in the present practices of use and concentrations described in this safety assessment.

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Section: Genotoxicity Studiesmentioning

confidence: 99%

Safety Assessment of Saccharide Esters as Used in Cosmetics

Scott¹,

Bergfeld²,

Belsito³

et al. 2021

Int J Toxicol

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“…*Statistically significant difference between control and samples (p < 0.05) SAIB is a food additive that is used in the beverage industry. Toxicological studies showed SAIB is one of the safest food additives with maximum acceptability up to 2000 ppm (Reynolds and Chappel 1998;Myhr et al 1998). However, SAIB is not a general choice of antioxidant for oil processing industries besides several other compounds.…”

Section: Resultsmentioning

confidence: 99%

Influence of natural and synthetic antioxidants on the degradation of Soybean oil at frying temperature

et al. 2015

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The effect of several natural and synthetic antioxidants to retard the formation of polar compounds and thermooxidation at prolonged frying temperatures was studied. Antioxidants, including butyl hydroxyl toluene (BHT), terbutyl hydroxyquinone (TBHQ), α-and γ-tocopherols, tocopherol mixture (α, β, γ and δ), sesamol, β-sitosterol, β-sitostanol, γ-oryzanol, curcumin, rosemary extract and sucrose acetate isobutyrate (SAIB) were tested in refined soybean oil without added any additives recovered from refinery. Rosemary extract and SAIB were showed a considerable effect on both polar compound formation and secondary oxidation. These compounds increased the oxidative stability of oil for more than 30 % compared to conventional synthetic antioxidants. Oils treated with SAIB showed higher color retention after 6 h heating compared to the oils added with BHT, TBHQ and tocopherols. Curcumin, sesamol and γ-oryzanol showed higher antioxidant potential compared to other antioxidants. Preliminary results obtained from this study have clearly demonstrated that SAIB and rosemary extracts are more commercially viable antioxidants to increase the stability of frying oils.

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Sucrose Acetate Isobutyrate (SAIB): Historical Aspects of its use in Beverages and a Review of Toxicity Studies Prior to 1988

Reynolds¹,

Chappel²

1998

Food and Chemical Toxicology

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Lack of genotoxic effects of sucrose acetate isobutyrate (SAIB)

Cited by 3 publications

References 9 publications

Safety Assessment of Saccharide Esters as Used in Cosmetics

Safety Assessment of Saccharide Esters as Used in Cosmetics

Influence of natural and synthetic antioxidants on the degradation of Soybean oil at frying temperature

Sucrose Acetate Isobutyrate (SAIB): Historical Aspects of its use in Beverages and a Review of Toxicity Studies Prior to 1988

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