Lack of Difference in Brain Hyperintensities Between Patients With Early Alzheimer's Disease and Control Subjects

Different mechanisms of corpus callosum atrophy in Alzheimer?s disease and vascular dementia

“…Although some authors found no significant white matter lesions in AD [5], white matter lesions are known to be encountered more frequently in senile onset AD than in age-matched controls [4,16,23]. However, in the present study, there was no correlation between the severity of white matter lesions and advancing age in the AD group.…”

Different mechanisms of corpus callosum atrophy in Alzheimer?s disease and vascular dementia

“…Although some authors found no significant white matter lesions in AD [5], white matter lesions are known to be encountered more frequently in senile onset AD than in age-matched controls [4,16,23]. However, in the present study, there was no correlation between the severity of white matter lesions and advancing age in the AD group.…”

Effect of the Apolipoprotein E ε4 Allele on White Matter Hyperintensities in Dementia

“…54 The fact that the apoE ⑀4 allele frequency in the WMH-positive patients corresponded to that of AD patients might indicate that the majority of these patients had AD pathology regardless of the presence of WMHs, because all of these patients actually fulfilled the NINCDS/ADRDA criteria for probable AD when the changes in WM and lacunar infarcts were disregarded. Our finding that WMHs were significantly associated with hypertension is compatible with previous reports 8,55,56 and supports the concept of an underlying hypertensive microangiopathy and chronic cerebral ischemia. 57 Lacunar infarcts in the basal ganglia, thalamus, and WM were usually accompanied with WM changes in Binswanger's disease.…”

Modified Visual Magnetic Resonance Rating Scale for Evaluation of Patients with Forgetfulness

“…Inconsistent with the literature, we observe that sulcal and ventricular enlargement together with the MTA and the prevalence and severity of WMH increase with age, and they appear more severely in AD patients 8 10 , 11 , 17 , 29 Unlike other studies, there is no significant difference between the two genders in terms of WMH, 2 , 17 although SAs, VAs, MTAs, and Ts are found to be higher in males compared with females, which supports the findings of Yue et al 2 …”

“…There are several verified and commonly used rating scales for visual scoring of WMH. 8,15,16,21 Similar to our study, in some of these scales frontal and occipital "caps" or pencil-thin linings are considered normal. 10,29 It has been shown that occipital "caps" are more common in all dementia groups (VD, AD, and LBD), whereas periventricular bands are more severe in AD and VD cases.…”

“…There are several verified and commonly used rating scales for visual scoring of WMH 8 15 , 16 , 21 Similar to our study, in some of these scales frontal and occipital “caps” or pencil-thin linings are considered normal 10 …”

Different mechanisms of corpus callosum atrophy in Alzheimer?s disease and vascular dementia

“…Although some authors found no significant white matter lesions in AD [5], white matter lesions are known to be encountered more frequently in senile onset AD than in age-matched controls [4,16,23]. However, in the present study, there was no correlation between the severity of white matter lesions and advancing age in the AD group.…”

Effect of the Apolipoprotein E ε4 Allele on White Matter Hyperintensities in Dementia

“…54 The fact that the apoE ⑀4 allele frequency in the WMH-positive patients corresponded to that of AD patients might indicate that the majority of these patients had AD pathology regardless of the presence of WMHs, because all of these patients actually fulfilled the NINCDS/ADRDA criteria for probable AD when the changes in WM and lacunar infarcts were disregarded. Our finding that WMHs were significantly associated with hypertension is compatible with previous reports 8,55,56 and supports the concept of an underlying hypertensive microangiopathy and chronic cerebral ischemia. 57 Lacunar infarcts in the basal ganglia, thalamus, and WM were usually accompanied with WM changes in Binswanger's disease.…”

Modified Visual Magnetic Resonance Rating Scale for Evaluation of Patients with Forgetfulness

“…Inconsistent with the literature, we observe that sulcal and ventricular enlargement together with the MTA and the prevalence and severity of WMH increase with age, and they appear more severely in AD patients 8 10 , 11 , 17 , 29 Unlike other studies, there is no significant difference between the two genders in terms of WMH, 2 , 17 although SAs, VAs, MTAs, and Ts are found to be higher in males compared with females, which supports the findings of Yue et al 2 …”

“…There are several verified and commonly used rating scales for visual scoring of WMH. 8,15,16,21 Similar to our study, in some of these scales frontal and occipital "caps" or pencil-thin linings are considered normal. 10,29 It has been shown that occipital "caps" are more common in all dementia groups (VD, AD, and LBD), whereas periventricular bands are more severe in AD and VD cases.…”

“…There are several verified and commonly used rating scales for visual scoring of WMH 8 15 , 16 , 21 Similar to our study, in some of these scales frontal and occipital “caps” or pencil-thin linings are considered normal 10 …”

Different mechanisms of corpus callosum atrophy in Alzheimer?s disease and vascular dementia

“…Although some authors found no significant white matter lesions in AD [5], white matter lesions are known to be encountered more frequently in senile onset AD than in age-matched controls [4,16,23]. However, in the present study, there was no correlation between the severity of white matter lesions and advancing age in the AD group.…”

Effect of the Apolipoprotein E ε4 Allele on White Matter Hyperintensities in Dementia

“…54 The fact that the apoE ⑀4 allele frequency in the WMH-positive patients corresponded to that of AD patients might indicate that the majority of these patients had AD pathology regardless of the presence of WMHs, because all of these patients actually fulfilled the NINCDS/ADRDA criteria for probable AD when the changes in WM and lacunar infarcts were disregarded. Our finding that WMHs were significantly associated with hypertension is compatible with previous reports 8,55,56 and supports the concept of an underlying hypertensive microangiopathy and chronic cerebral ischemia. 57 Lacunar infarcts in the basal ganglia, thalamus, and WM were usually accompanied with WM changes in Binswanger's disease.…”

Modified Visual Magnetic Resonance Rating Scale for Evaluation of Patients with Forgetfulness

“…Inconsistent with the literature, we observe that sulcal and ventricular enlargement together with the MTA and the prevalence and severity of WMH increase with age, and they appear more severely in AD patients 8 10 , 11 , 17 , 29 Unlike other studies, there is no significant difference between the two genders in terms of WMH, 2 , 17 although SAs, VAs, MTAs, and Ts are found to be higher in males compared with females, which supports the findings of Yue et al 2 …”

“…There are several verified and commonly used rating scales for visual scoring of WMH. 8,15,16,21 Similar to our study, in some of these scales frontal and occipital "caps" or pencil-thin linings are considered normal. 10,29 It has been shown that occipital "caps" are more common in all dementia groups (VD, AD, and LBD), whereas periventricular bands are more severe in AD and VD cases.…”

“…There are several verified and commonly used rating scales for visual scoring of WMH 8 15 , 16 , 21 Similar to our study, in some of these scales frontal and occipital “caps” or pencil-thin linings are considered normal 10 …”