Lack of Association ofCYP1A1Polymorphism with Prostate Cancer Susceptibility of Tunisian Men

Abstract

Cytochrome P450 (CYP)1A1 gene polymorphism has been shown to be associated with several diseases. In this study, we evaluated the association between the polymorphism in the cytochrome P-450 (CYP)1A1 (CYP1A1) gene and genetic susceptibility to prostate cancer (PCa) in Tunisian men. One hundred and thirty eight PCa patients and the same number of controls were enrolled in this study. All DNA samples from peripheral blood leucocytes were genotyped for genetic polymorphism of the CYP1A1 gene using the polymerase chain reaction-restriction fragment length polymorphism method. The polymorphism in PCa patients was also analyzed according to age at diagnosis, tobacco use, cancer stage, and grade (Gleason score). The prevalence of CYP1A1 variants (w1m1 and m1m1) was similar in PCa patients and controls (15.22% vs. 17.39%, p=0.624 and 2.17%, respectively). No significant difference in the frequency distribution of CYP1A1 polymorphism was observed between PCa patients and controls. Furthermore, we were unable to demonstrate any significant association between the studied CYP1A1 polymorphism, age, tobacco use, and tumor parameters of aggressiveness at diagnosis.

Association of CYP1A1, GSTM1 and GSTT1 gene polymorphisms with risk of prostate cancer in Algerian population

“…In the present study, no links were detected between PCa and T3801C polymorphism. Our results are consistent with previous reports: Souiden et al [20], Mandić et al [21] found that there is no significant association between T3801C polymorphism of CYP1A1 and PCa in the Tunisian and Caucasian populations, respectively. In addition, the results published by Li et al [22] revealed that no correlation between T3801C polymorphism of CYP1A1and predisposition to PCa.…”

RETRACTED: Relationship Between Aldosterone Synthase CYP1A1 MspI Gene Polymorphism and Prostate Cancer Risk

“…Seventeen studies [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18] reporting the relationship between CYP1A1 MspI gene polymorphism and prostate cancer susceptibility were included into this meta-analysis (Table 1). Ten studies were performed in Asians, 2 in caucasians, and 3 in Africans.…”

Contribution of ABO-Rhesus/Electrophoresis of hemoglobin methods and Short Tandem Repeats analysis in the determination of paternity in Burkina Faso, West Africa

“…Similarly, the rhesus system alone may reveal an exclusion, as is the case for example for an O-mother, O + child and O-father [14]. But in some particular cases, such as mother O+, child A1, father O + and if the ABO system is the only exclusion system, paternity is excluded only if it can be shown that one of the parents does not have the Bombay phenotype [15]. On the other hand, the immaturity of antigens in all newborns should be considered; for example, in the following example: mother O, child A2, father A1B, the child's blood type should be checked a few months later before reporting an exclusion, as this may be a delay in the development of the A1 antigen.…”