Lack of Association between Helicobacter pylori Infection and Biliary Tract Diseases

Sherafat, Somayeh Jahani; Tajeddin, Elahe; Majidi, Mohammad Reza; Vaziri, Farzam; Alebouyeh, Masoud; Alizadeh, Amir Hooshang Mohammad; Nazemalhosseini‐Mojarad, Ehsan; Zali, Mohammad Reza

doi:10.33073/pjm-2012-044

Cited by 10 publications

(6 citation statements)

References 18 publications

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“…did not show any growth, but the presence of Helicobacter pylori DNA by PCR was detected in 3.92% of them. No significant association was found between the development of the diseases and presence of the bacteria [75].…”

Section: Helicobacter Pylori and Helicobacter Spp In Bile Gallbladder Tissue And Gallstonesmentioning

confidence: 79%

“…Helicobacter spp. and Helicobacter pylori in bile samples, gallbladder tissue, and gallstones were detected by several methods: using cultures [52,59,67,71], by immunohistochemistry [46], by urease test, Giemsa, and immunohistochemical stain [72], by 16S rRNA PCR-amplification, by nested and multiplex PCR [47,[54][55][56][59][60][61][62][63][64]67,71,[73][74][75][76][77], by PCR-DGGE [52], both by PCR and by an ELISA study of the specific antigen (H. pylori stool antigen) [47], by ELISA after a preabsorption step using H. pylori antigens [46,78], by a Western blot analysis of Helicobacter antibodies [67], or by WMS sequencing and 16S rRNA sequencing on bile samples [35].…”

Section: Helicobacter Pylori and Helicobacter Spp In Bile Gallbladder Tissue And Gallstonesmentioning

confidence: 99%

“…The CagA protein of H. pylori has been found to have a homology with aminopeptidase and can therefore increase the risk for gallstone formation [49]. H. pylori may also promote the risk of stone formation by acting as a foreign body to form a nidus around which the stone may develop, or it may produce hydrolyzing enzymes or nucleating proteins such as immunoglobulins [75]. However, Griniatsos et al [83], in contrast, consider that H. pylori does not have a lithogenic potential for the formation of cholesterol gallstones.…”

Section: Helicobacter Pylori and Helicobacter Spp In Bile Gallbladder Tissue And Gallstonesmentioning

confidence: 99%

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Gallstone Disease and Microbiome

Григорьева

Romanova

2020

Microorganisms

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Gallstone disease (GSD) has, for many years, remained a high-cost, socially significant public health problem. Over the past decade, a number of studies have been carried out—both in humans and in animal models—confirming the role of the microbiota in various sections of the gastrointestinal tract as a new link in the etiopathogenesis of GSD. The microbiome of bile correlates with the bacterial composition of saliva, and the microbiome of the biliary tract has a high similarity with the microbiota of the duodenum. Pathogenic microflora of the oral cavity, through mechanisms of immunomodulation, can affect the motility of the gallbladder and the expression of mucin genes (MUC1, Muc3, MUC4), and represent one of the promoters of stone formation in the gallbladder. The presence of H. pylori infection contributes to the formation of gallstones and affects the occurrence of complications of GSD, including acute and chronic cholecystitis, cholangitis, pancreatitis. Intestinal bacteria (Clostridium, Bifidobacterium, Peptostreptococcus, Bacteroides, Eubacterium, and Escherichia coli) participating in the oxidation and epimerization of bile acids can disrupt enterohepatic circulation and lead to the formation of gallstones. At the same time, cholecystectomy due to GSD leads to the further transformation of the composition of the microbiota in various parts of the gastrointestinal tract, increasing the risk of developing stomach cancer and colorectal cancer. Further research is required to determine the possibility of using the evaluation of the composition of the microbiota of the gastrointestinal and biliary tracts as an early diagnostic marker of various gastroenterological diseases.

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Section: Helicobacter Pylori and Helicobacter Spp In Bile Gallbladder Tissue And Gallstonesmentioning

confidence: 79%

Section: Helicobacter Pylori and Helicobacter Spp In Bile Gallbladder Tissue And Gallstonesmentioning

confidence: 99%

Section: Helicobacter Pylori and Helicobacter Spp In Bile Gallbladder Tissue And Gallstonesmentioning

confidence: 99%

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Gallstone Disease and Microbiome

Григорьева

Romanova

2020

Microorganisms

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“…However, studies conducted so far showed a high variability in methods and also in findings. In some studies a strong association between H. pylori and biliary tract diseases was reported, while others failed to find a statistically significant association [28-30]. Furthermore, some studies have examined the link between H. pylori infection and cholecystitis, gallbladder cancer, but results have been inconsistent [31-43].…”

Section: Discussionmentioning

confidence: 99%

Linking Helicobacter pylori with gallbladder and biliary tract cancer in Moroccan population using clinical and pathological profiles

et al. 2019

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It is of interest to assess the clinical and pathological aspects of Gallbladder and biliary tract carcinomas confirmed by histological data. It is also of further interest to evaluate the link between Helicobacter pylori and biliary tract cancers. Eighty-nine (89) cases (mean age 60±12 years) of Gallbladder and biliary tract cancer confirmed by histological data were enrolled for the study at the Department of Pathology in Mohammed VI University Hospital, in Morocco. The data such as age, sex, clinical and histo pathological features were collected. Bile duct specimens were investigated for H. pylori using Giemsa and immuno histo chemistry staining. Results show that bile duct stones were found in 53.9% of cases. It is known using histological data that adeno carcinoma is common accounting for 70 % of all bile duct tumors. Moreover, Helicobacter pylori was detected in 54% of cases linking with the presence of bile duct stones characterized by the histological subtype, the macroscopic classification and lymph node's presence (p<0.001). Thus, data collected suggest the potential association of Helicobacter pylori with gallbladder cancer possibly through the formation of bile duct stones.

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“…Since then, more and more studies reported the existence of H. pylori in the bile, tissue, and stones of patients with chronic cholecystitis/cholelithiasis and tried to explain the relationship between them . It is a pity that it did not confirm any association between H. pylori infection and cholesterol gallstone formation in a mice study .…”

Section: Introductionmentioning

confidence: 99%