Lack of Association between Family History of Stroke and 1‐year Outcomes after Acute Ischemic Stroke in Chinese

Wang, Xingao; Wang, Chunxue; Yang, Huajun; Wang, An-Xin; Liu, Dong; Zheng, Huaguang; Wang, Yilong; Liu, Gaifen; Zhao, Xingquan; Wang, Yongjun

doi:10.1111/cns.12164

Cited by 8 publications

(10 citation statements)

References 8 publications

(8 reference statements)

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“…24 Another study, which was based on a Chinese national stroke registry, indicated that family history of stroke was not associated with 1-year stroke recurrence. 15 In agreement with previous studies, we found that neither the overall family history of stroke nor the parental stroke history was associated with a significantly increased risk of recurrent stroke. However, more detailed attributes of the family histories were found to have predictive value for recurrent stroke in our patients.…”

Section: Discussionsupporting

confidence: 92%

“…However, family histories of stroke in first-degree relatives and parents were not predictors of recurrent stroke in previous studies. 7,15 Family history of stroke is a complex profile that includes the types of affected relatives (ie, paternal, maternal, or sibling), the ages of relatives at stroke onset (early onset versus late onset), and other characteristics. In addition, a family history of stroke may have different effects on the risk of stroke recurrence, depending on the patient's age of stroke onset.…”

mentioning

confidence: 99%

“…We hypothesized that these complexities might explain the apparent lack of association between family history and stroke recurrence that has been reported in previous studies. 7,15 Here, we sought to test this hypothesis using a nationwide prospective stroke registry database.…”

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confidence: 99%

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Family History and Risk of Recurrent Stroke

Chung

Kim

Han

et al. 2016

Stroke

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Background and Purpose-The association between family history of stroke and stroke recurrence remains unclear. Methods-Using a web-based multicenter stroke registry database, information on history of stroke in first-degree relatives was collected prospectively for acute ischemic stroke patients who were hospitalized within 7 days of onset. The collected information was categorized as follows: type of the affected relative(s) with stroke (paternal, maternal, sibling, or 2 or more) and age of the relative's stroke onset (<50, 50-59, 60-69, and ≥70 years). Stroke recurrence was captured prospectively using a predetermined protocol. Subgroup analyses were performed according to the patient's age at the index stroke. Results-Among 7642 patients, 937 (12.3%) had a history of stroke in their first-degree relatives and 475 (6.2%: 201 within and 274 after 3 weeks from index stroke) experienced stroke recurrence (median follow-up, 365 days). In multivariable Cox proportional hazard models, overall family history was not associated with stroke recurrence (hazard ratio, 1.08; 95% confidence interval, 0.81-1.43). However, the details of their family histories, including relative's age at stroke onset (<50 years: hazard ratio, 2.14; 95% confidence interval, 1.004-4.54) and stroke history in a sibling (hazard ratio, 1.67; 95% confidence interval, 1.09-2.58), were independently associated with stroke recurrence after adjusting for potential confounders. The associations appeared to be stronger in young adults with stroke (age, <55 years) than in older stroke patients. Conclusions-This study suggests that elevated risks of recurrent stroke are associated with having relatives with earlyonset stroke and siblings with stroke histories, implying that additional precautions may be needed in such populations.

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Section: Discussionsupporting

confidence: 92%

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confidence: 99%

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Family History and Risk of Recurrent Stroke

Chung

Kim

Han

et al. 2016

Stroke

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“…This may be explained by the small sample size and high prevalence of conventional vascular risk factors (87.8%) in familial young stroke, thus suggesting the complex gene-environment interactions in individual subtypes. Indeed, the familial aggregation of vascular risk factors has also been observed in stroke patients worldwide [35]. Nevertheless, consistent with a previous Spanish case-control study, our study showed that ICH was not significantly associated with family history of stroke [36].…”

Section: Discussionsupporting

confidence: 89%

Young Adult Stroke in Taiwan: etiologies and outcomes

Chen

Lin

Syu

et al. 2019

Preprint

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Background Early-onset adult stroke has not been fully characterized in Asians. Objectives We investigated the etiologic subtypes, risk factors and 1-year outcomes of early-onset stroke (16 – 55 years of age) in a Taiwanese cohort. Methods We retrospectively reviewed consecutive patients with acute stroke admitted to the Taipei Veterans General Hospital in Taiwan between 2009 and 2017. Patients were classified by age of onset (≤ or > 55) and etiologic subtypes and regularly followed for 1 year. Results Among all stroke patients (n=8155), 17.6% (n=1310) were early-onset, who had slightly more spontaneous hemorrhagic stroke (50.8%) than ischemic stroke (49.2%). The most common etiologic subtypes of hemorrhagic stroke were hypertensive intracerebral hemorrhage (ICH), subarachnoid hemorrhage and undetermined ICH. The most common subtypes of infarction were large artery atherosclerosis, other determined diseases (52.5% arterial dissection) and embolic stroke of undetermined source. Smoking, alcohol overdrink, obesity, ischemic heart disease and family history of stroke were more in the early-onset than the elderly patients. The early-onset patients with familial stroke (n=87, 6.6%) were more males and more commonly had infarction than those without familial stroke. Monogenic diseases accounted for 5.7% of young familial stroke. At 1-year follow-up, the early-onset patients with infarction displayed greater functional improvements but more stroke recurrence than those with ICH. Conclusions Hypertensive hemorrhagic stroke and large artery atherosclerosis or dissection occlusion are characteristically common etiologies of young stroke in Taiwan. Early-onset infarction had higher recurrence yet better 1-year outcomes than early-onset ICH. Patients with familial versus non-familial aggregation had more ischemic infarction and monogenic diseases.

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“…Second stroke [41,77,78,[87][88][89][90][91][92] FHS increased the overall risk of second stroke according to some [41,[87][88][89][90], but not other authors [77,[91][92], whereas one study confirmed this association only in subgroups [78].…”

Section: Parameter Publications Correlationmentioning

confidence: 99%

Family history of stroke – a useful clue for the primary care physician and stroke neurologist: a narrative review

Błaż¹,

Sarzyńska‐Długosz²

2023

ppn

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Purpose:The heritability of ischemic stroke is a complex mechanism, involving the contribution of genetic traits and environmental factors, which is why in everyday practice clinicians often rely on the broad term "family history of stroke", defined as the case of any first-degree relative who has had a stroke. The aim of this review is to update the available data regarding family history of stroke in primary and secondary stroke prevention by searching the electronic Scopus database for the phrase TITLE-ABS-KEY ("family history" AND "stroke"). Views: A total of 140 articles met the pre-specified criteria and were included in the review. The prevalence of family history of stroke ranged from 37% in stroke-free individuals to 52% in patients with ischemic stroke. In primary prevention, family history of stroke was associated with increased risk of stroke, transient ischemic attack, stroke risk factors and stroke-like symptoms. In patients with ischemic stroke, it was more often associated with small-and large-vessel disease, though not with a cardioembolic etiology. Family history of stroke did not influence long-term functional outcomes after rehabilitation. In young stroke victims, it was related to symptom severity and the risk of a second stroke. Conclusions: Consideration of family history of stroke in everyday practice may carry useful information both for primary care physicians and stroke neurologists.

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Lack of Association between Family History of Stroke and 1‐year Outcomes after Acute Ischemic Stroke in Chinese

Cited by 8 publications

References 8 publications

Family History and Risk of Recurrent Stroke

Family History and Risk of Recurrent Stroke

Young Adult Stroke in Taiwan: etiologies and outcomes

Family history of stroke – a useful clue for the primary care physician and stroke neurologist: a narrative review

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