Laboratory test features of newly diagnosed adult HIV-infected patients in Ouagadougou (Burkina Faso)

Sagna, Yempabou; Koulidiaty, J.; Diallo, I; Sanou, A.; Bagbila, P Abraham; Sagna, T.; Nébié, Issa; Guira, Oumar; Tiéno, H.; Drabo, Y. J.

doi:10.1684/mst.2014.0381

Cited by 2 publications

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“…Several studies have highlighted the high incidence of hyperamylasemia in HIV infection, with over 40% in some series [8]. In Burkina Faso, several studies have been carried out on pancreatic enzymes in the context of HIV [8,9]; but few have focused on the pediatric context. The onset of pancreatic complications at an early age could considerably shorten the life expectancy of these patients.…”

Section: Introductionmentioning

confidence: 99%

Serum Amylase Activity in Children Living with HIV-1 at the Charles de Gaulle Pediatric University Hospital in Ouagadougou

Soudre,

Kouraogo,

Nombre

et al. 2024

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Biological monitoring is an essential part of the management of HIV infection. The aim of this study was to assess serum amylase activity during follow-up of children living with HIV-1 (CLHIV-1) at the Charles de Gaulle Pediatric University Hospital (CHUP-CDG). This was a descriptive and analytical cross-sectional study, with retrospective data collection from January 1, 2020 to December 31, 2022. Patients under 15 years of age who were being monitored for HIV-1 at CHUP-CDG and who had undergone a serum amylase assay during the study period were included. A total of 746 patients have been included, with a M/F sex ratio of 0.91 and a mean age of 8.52±4.08 years. Among CLHIV-1, 88.05% had a TCD4 lymphocyte count > 500/mm3 and 60.32% an undetectable plasma viral load (PVL). The incidence of hyperamylasemia in the study population was 57.64%. Hyperamylasemia was significantly more frequent in children aged 0-2 years (p<0.00001), in patients with a high PVL (p=0.0016) and in those on the protocol combining two nucleoside reverse transcriptase inhibitors with a protease inhibitor. Several abnormalities in serum amylase activity were detected in CLHIV-1 during the course of the study. Clinical correlation and adequate follow-up of these abnormalities are essential to reduce the morbidity and mortality associated with pancreatic damage in people living with HIV.

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Section: Introductionmentioning

confidence: 99%

Serum Amylase Activity in Children Living with HIV-1 at the Charles de Gaulle Pediatric University Hospital in Ouagadougou

Soudre,

Kouraogo,

Nombre

et al. 2024

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Molecular Epidemiology of Human Herpes Virus Type 8 Among Patients with Compromised Immune System in Ouagadougou, Burkina Faso

Biatougou¹,

Ouédraogo²,

Soubeïga³

et al. 2022

HIV

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Introduction Human herpesvirus type 8 (HHV-8) is the main etiological agent of Kaposi’s sarcoma. This virus is frequently associated with immunocompromision. This study aimed to detect HHV-8 in people with compromised immune system. Patients and Methods This is a cross-sectional study that included 180 subjects: 179 HIV-infected patients and 1 patient with bullous pemphigoid. Blood samples were taken from all subjects, and swabs of lesions were then taken from individuals with symptoms of Kaposi’s sarcoma. Viral load and CD4 + T lymphocytes count were performed for persons living with HIV and real-time PCR detection of HHV-8 DNA was performed in all subjects in the study. Results Among HIV-infected persons, 13.41% had a viral load of more than 10,000 copies/mL, and 22.91% had a CD4 + T lymphocytes count of fewer than 350 cells/µL. A total of four (three HIV-1 infected patients and one patient with bullous pemphigoid) patients (2.22%) had apparent lesions of Kaposi’s sarcoma. In the plasmas and swabs from associated lesions, HHV-8 DNA was found in only two individuals, with an HHV-8 prevalence of 1.11% (2/180) with 0.55% (1/179) in an HIV-infected patient on antiretroviral therapy. Conclusion These results exposing low prevalence levels of HHV-8 in HIV-infected patients could be due to the beneficial effect of antiretroviral drugs.

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Laboratory test features of newly diagnosed adult HIV-infected patients in Ouagadougou (Burkina Faso)

Cited by 2 publications

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Serum Amylase Activity in Children Living with HIV-1 at the Charles de Gaulle Pediatric University Hospital in Ouagadougou

Serum Amylase Activity in Children Living with HIV-1 at the Charles de Gaulle Pediatric University Hospital in Ouagadougou

Molecular Epidemiology of Human Herpes Virus Type 8 Among Patients with Compromised Immune System in Ouagadougou, Burkina Faso

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