Laboratory features of 160 CCHF confirmed cases in Zabol of Iran: A 10-year study

Osquee, Hamid Owaysee; Pourjafar, Hadi; Taghizadeh, Sepehr; Haghdoost, Mehdi; Ansari, Fereshteh

doi:10.1016/j.jinf.2016.12.003

Cited by 4 publications

(4 citation statements)

References 7 publications

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“…Typical laboratory abnormalities in SARS-CoV-2 infection include elevated D-dimer, ferritin, and CRP levels and lymphopenia, while CCHF predominantly manifests as thrombocytopenia and impaired liver function and coagulation tests (11,12).…”

Section: Discussionmentioning

confidence: 99%

SARS-CoV-2 and Crimean-Congo hemorrhagic fever virus coinfection: A case report and review of the diagnostic challenges

Afshar,

Barary,

Babazadeh

et al. 2023

Preprint

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The coronavirus disease 2019 has overshadowed other infectious diseases due to its prolonged pandemic. This has resulted in seasonal or endemic infections coinciding with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), like Crimean-Congo hemorrhagic fever virus (CCHFV). Here, we reported that a 36-year-old male shepherd presented with fever, myalgia, and abdominal pain diagnosed with CCHFV and SARS-CoV-2 coinfection.

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Section: Discussionmentioning

confidence: 99%

SARS-CoV-2 and Crimean-Congo hemorrhagic fever virus coinfection: A case report and review of the diagnostic challenges

Afshar,

Barary,

Babazadeh

et al. 2023

Preprint

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“…The control group patients had brucellosis (n=7, 17.5%), influenza (n=7, 17.5%), and pneumonia (n=7, 17.5%) as the most common diagnoses (Table 4). E a r l y A c c e s s DISCUSSION CCHF cases may show some clinical symptoms, including leukopenia, leukocytosis, anemia, thrombocytopenia, elevated AST and ALT levels, increased LDH levels, raised creatine phosphokinase (CPK) levels, prolonged prothrombin time (PT), aPTT levels, increased D-dimer levels, and elevated amounts of fibrin breakdown products (5)(6)(7)(8)(9)(10). We detected elevations in thrombocytopenia, leukopenia, CK, and D-dimer levels in our CCHF group, as well as reduced levels of fibrinogen.…”

Section: E a R L Ymentioning

confidence: 99%

“…CCHF virus infection first leads to virus proliferation in dendritic cells and other local tissues, followed by virus migration to regional lymph nodes and subsequent spread to a wide variety of tissues and organs, including the liver, spleen, and lymph nodes via lymphocytes and monocytes (1). Biomarkers are urgently needed for the diagnosis and prognosis of this high-mortality disease, and many studies in the literature have addressed this purpose (5)(6)(7)(8)(9)(10). One potential biomarker is the urokinase-type plasminogen activator (uPA) system.…”

Section: Introductionmentioning

confidence: 99%

The Diagnostic Value of Soluble Urokinase Plasminogen Activator Receptor in Crimean-Congo Hemorrhagic Fever Disease in Emergency Department

Küçükceran

Karaşahin

Delice

et al. 2021

Düzce Tıp Fakültesi Dergisi

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Aim: The urokinase-type plasminogen activator (uPA) system consists of a protease, a receptor (urokinase-type plasminogen activator receptor, uPAR), and inhibitors that can be expressed on various cell types. Previous literature shows that the amount of soluble urokinase-type plasminogen activator receptor (suPAR) secreted from affected cells is higher in Crimean-Congo hemorrhagic fever (CCHF) patients than in healthy controls. Thus, we aimed to investigate the diagnostic value of suPAR in the differential diagnosis of CCHF in emergency services. Material and Methods: Individuals over 16 years old with a preliminary diagnosis of CCHF disease were divided into two groups as real time-polymerase chain reaction (RT-PCR) and/or IgM positive (CCHF group) and RT-PCR and/or IgM negative (control group). Results: Eighty patients were included in this study. Forty patients with CCHF virus PCR and/or CCHF virus IgM were identified as CCHF group and 40 patients included as negative control group. The median age of the patients was 45 (range, 16-91) years, and 49 patients (61.3%) were male. Leukocyte, platelet, and fibrinogen levels were significantly lower, while creatinine kinase, aPTT, and D-dimer levels were significantly higher in CCHF group. There was no statistically significant difference between the control group and CCHF group for SuPAR (p=0.386). In addition, control group patients not diagnosed with CCHF were examined, brucellosis, influenza, and pneumonia were found to be the most common. Conclusion: The use of suPAR as a biomarker in the differentiation of patients with similar findings in emergency services was investigated and found to have no diagnostic value.

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“…For example, in a study reviewing the clinical features of 160 CCHF patients, fever was noted in 99.4% of cases. [30] Since it was reported that the patient had been ill for 5 days prior to admission, a history of antipyretic use is important to consider as a possible reason for apyrexial presentation. Regardless of this uncommon presentation, given the fact that the patient was a farmer from a CCHF endemic area, the blood results indicating multisystem involvement and the clinical presentation (apart from no fever), including bleeding signs (ecchymosis, bleeding from venepuncture sites), could fit the diagnosis of CCHF.…”

Section: In Practicementioning

confidence: 99%

Atypical presentation of Crimean-Congo haemorrhagic fever: Lessons learned

et al. 2019

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An atypical case of Crimean-Congo haemorrhagic fever is presented. The diagnosis of the case in the presence of several comorbidities was complicated and illustrates the importance of maintaining a high index of suspicion for viral haemorrhagic fever in cases presenting with multisystem disease and an epidemiological history that could present opportunities for exposure to a haemorrhagic fever virus.S Afr Med J 2019;109(2):91-94.

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Laboratory features of 160 CCHF confirmed cases in Zabol of Iran: A 10-year study

Cited by 4 publications

References 7 publications

SARS-CoV-2 and Crimean-Congo hemorrhagic fever virus coinfection: A case report and review of the diagnostic challenges

SARS-CoV-2 and Crimean-Congo hemorrhagic fever virus coinfection: A case report and review of the diagnostic challenges

The Diagnostic Value of Soluble Urokinase Plasminogen Activator Receptor in Crimean-Congo Hemorrhagic Fever Disease in Emergency Department

Atypical presentation of Crimean-Congo haemorrhagic fever: Lessons learned

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