Laboratory evaluation of the new Access® cytomegalovirus immunoglobulin IgM and IgG assays

Carlier, Pol; Harika, Nawal; Bailly, Ronald; Vranken, G.

doi:10.1016/j.jcv.2010.07.024

Cited by 24 publications

(15 citation statements)

References 18 publications

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“…Although our results should be considered estimates due to the limitation that only 10% of the BIFA-negative/ EIA-negative serum samples were tested by ELFA and CIA, they support previously published data from CMV IgM method comparison studies (15,(17)(18)(19)(20)(21). The pairwise concordance rates between EIA, ELFA, and CIA were all Ͼ90%; in contrast, the concordance rates of these 3 assays with BIFA were lower (84% to 86%), due in large part to sera that were positive by BIFA but not by the other three assays.…”

Section: Discussionsupporting

confidence: 89%

Potential Impact of Different Cytomegalovirus (CMV) IgM Assays on an Algorithm Requiring IgM Reactivity as a Criterion for Measuring CMV IgG Avidity

Prince

Lapé-Nixon

Brenner

et al. 2014

Clin Vaccine Immunol

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The measurement of cytomegalovirus (CMV) IgG avidity is a powerful tool for identifying individuals with recent CMV infection. Because such patients are expected to be positive for CMV IgM, several investigators have suggested that CMV IgG-positive sera first be screened for CMV IgM and then only the IgM-reactive sera be tested for avidity. We investigated the impact of different CMV IgM assays on such a reflexing algorithm using a panel of 369 were IgM negative by BIFA, 10 by ELFA, and 15 by EIA and CIA. In both these avidity groups, BIFA IgM-negative sera were also negative by the other 3 assays. These findings demonstrate that an algorithm requiring CMV IgM reactivity as a criterion for CMV IgG avidity testing does not identify all low-avidity sera and thus misses some cases of acute CMV infection.

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Section: Discussionsupporting

confidence: 89%

Potential Impact of Different Cytomegalovirus (CMV) IgM Assays on an Algorithm Requiring IgM Reactivity as a Criterion for Measuring CMV IgG Avidity

Prince

Lapé-Nixon

Brenner

et al. 2014

Clin Vaccine Immunol

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“…The IgG assay is nearly 100% sensitive and specific, readily available, and automated for high volume capacities. 14,15 The high anti-CMV antibody of 91.1% observed among pregnant women in MMSH Kano is due primary infection and/or secondary infection with intermittent excretion of virus as a result of reactivation of an endogenous virus or exposure to new virus strain from exogenous sources. This is similar to a study among 5,959 pregnant women in Izmir Turkey 16 in which 98.3% IgG seropositivity was observed; 179 pregnant women in Lagos southwest Nigeria where pregnant women had 97.2% anti-CMV IgG antibodies.…”

Section: Discussionmentioning

confidence: 99%

Seroprevalence of cytomegalovirus among pregnant women attending Murtala Mohammed Specialist Hospital Kano, Nigeria

Hamid¹,

Onoja²,

Tofa³

et al. 2014

Afr H. Sci.

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“…The IgG assay is nearly 100% sensitive and specific, readily available, and automated for high volume capacities [34,35]. In the absence of universal serial serologic screening of pregnant women, diagnosis via seroconversion is seldom achieved since an initial seronegative serum is rarely available.…”

Section: Accurate Methods For Serologic Diagnosismentioning

confidence: 99%

Screening for cytomegalovirus during pregnancy

Adler

Nigro

Pereira

2010

American Journal of Obstetrics and Gynecology

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The epidemiology and pathogenesis of CMV infections among pregnant women have been intensely studied over the last three decades. This paper highlights recent developments that make either universal or limited serologic screening for CMV during pregnancy potentially attractive. The developments include an understanding of the pathogenesis of CMV infections, a knowledge of high-risk women, the availability of accurate methods for the serologic diagnosis of a primary CMV infection using either single or serial blood samples, accurate methods for the diagnosis of fetal infection via amniotic fluid, sensitive fetal and placental indicators for neonatal outcomes, and the availability of potentially effective interventions.

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Laboratory evaluation of the new Access® cytomegalovirus immunoglobulin IgM and IgG assays

Cited by 24 publications

References 18 publications

Potential Impact of Different Cytomegalovirus (CMV) IgM Assays on an Algorithm Requiring IgM Reactivity as a Criterion for Measuring CMV IgG Avidity

Potential Impact of Different Cytomegalovirus (CMV) IgM Assays on an Algorithm Requiring IgM Reactivity as a Criterion for Measuring CMV IgG Avidity

Seroprevalence of cytomegalovirus among pregnant women attending Murtala Mohammed Specialist Hospital Kano, Nigeria

Screening for cytomegalovirus during pregnancy

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