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Cited by 47 publications
(29 citation statements)
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References 21 publications
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“…17 The concentrations of the anticoagulants used in this study were far less than the concentrations present in plasma, which contains about 0.3 mg/ml of antithrombin III and about 3.0 mg/ml of alpha 2 -macroblobulin. 18 Thus the 1 unit/ml of antithrombin III used in these experiments would represent approximately 1/490 to 1/630 of the antithrombin activity normally present in human plasma. Moreover, 1 unit of antithrombin III represents about 2 /xg/ml of protein in these experiments.…”
Section: Discussionmentioning
confidence: 95%
See 1 more Smart Citation
“…17 The concentrations of the anticoagulants used in this study were far less than the concentrations present in plasma, which contains about 0.3 mg/ml of antithrombin III and about 3.0 mg/ml of alpha 2 -macroblobulin. 18 Thus the 1 unit/ml of antithrombin III used in these experiments would represent approximately 1/490 to 1/630 of the antithrombin activity normally present in human plasma. Moreover, 1 unit of antithrombin III represents about 2 /xg/ml of protein in these experiments.…”
Section: Discussionmentioning
confidence: 95%
“…11 It also inhibits contractions of basilar arteries produced by xanthochromic CSF of SAH patients (unpublished observations) and inhibits a variety of serine proteases. 18 Such actions might delay the appearance of vasospasm which occurs late in the course of SAH. 3 The absence of a contractile response to kallikrein was unexpected, because other serine proteases (trypsin, plasmin, and thrombin) elicit vasoconstriction in isolated canine basilar arteries.''…”
Section: Discussionmentioning
confidence: 99%
“…A normal AT III (MW 65,000 [3]) concentration in patients with NS was found by Jorgensen and Sloffersen [6], Panicucciet al [13], and Wagoner el al. [18].…”
Section: Discussionmentioning
confidence: 70%
“…In the pathogenesis of thrombosis, in addition to promoting factors, a very important role is played by thrombin inhibitors. There are at least three thrombin inhibitors in the human plasma: antithrombin III (AT III), a r antitrypsin ( a r AT), and a r macroglobulin (a r M) [5], The most important is AT III [3].…”
Section: Introductionmentioning
confidence: 99%
“…During activation of DIC, there is irreversible complexing of thrombin and circulating activated clotting factors with antithrombin, leading to considerable decreases in functional antithrombin. Several studies have compared the clinical applicability of various antithrombin methodologies and based upon these studies synthetic substrate assays are clearly the method of choice [156,157]. Immunological assays for antithrombin ignore biological function and may be low or normal in DIC, and therefore should not be used [3-5, 73, 154].…”
Section: Molecular Markers For the Diagnosis Of Dicmentioning
confidence: 99%