Label-free selective detection of ampicillin drug in human urine samples using silver nanoparticles as a colorimetric sensing probe

Shrivas, Kamlesh; Sahu, Jharna; Maji, Pathik; Sinha, Debabrata

doi:10.1039/c7nj00448f

Cited by 60 publications

(20 citation statements)

References 27 publications

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“…In addition, because of desirable magnetic properties (15 emu/g), it is easier to separate sorbent from sample and realize recycling than nonmagnetic MOF. From the analytical aspect, the linear range and LOD of the proposed method were approximately the same or better than those of some other methods, which represents the promising future of our present MMOF for determination of AMP from complicated cow milk samples [ 3 , [41] , [42] , [43] ] ( Table 3 ). Moreover, the prepared MMOF was compared with some commercial sorbents presented in Table 4 [ [44] , [45] , [46] , [47] , [48] , [49] , [50] , [51] , [52] , [53] , [54] ].…”

Section: Resultsmentioning

confidence: 72%

“…AMP overdose can cause behavioral changes, confusion, blackouts, and convulsions, as well as neuromuscular hypersensitivity, electrolyte imbalance, and renal failure. The maximum residue limits (MRLs) for ampicillin in milk and meat have been set by the European Union (EU) at 40 and 50 μg/kg, respectively [ 3 ]. In 1999, the EU forbade the use of antibiotics as additives in animal feed, but they are still use in some countries.…”

Section: Introductionmentioning

confidence: 99%

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Magnetic metal organic framework for pre-concentration of ampicillin from cow milk samples

Bagheri

Ghaedi

2020

Journal of Pharmaceutical Analysis

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The aim of this study is a present of a simple solvothermal synthesis approach to preparation of Cu-based magnetic metal organic framework (MMOF) and subsequently its application as sorbent for ultrasound assisted magnetic solid phase extraction (UAMSPE) of ampicillin (AMP) from cow milk samples prior to high performance liquid chromatography-Ultraviolet (HPLC-UV) determination. Characteristics of prepared MMOF were fully investigated by different techniques which showed the exclusive properties of proposed sorbent in terms of proper functionality, desirable magnetic property and also high specific surface area. Different influential factors on extraction recovery including sorbent dosage, ultrasonic time, washing solvent volume and eluent solvent volume were assessed using central composite design (CCD) based response surface methodology (RSM) as an operative and powerful optimization tool. This is the first report for determination of AMP using MMOF. The proposed method addressed some drawbacks of other methods and sorbents for determination of AMP. The presented method decreases the extraction time (4 min) and also enhances adsorption capacity (250 mg/g). Moreover, the magnetic property of presented sorbent (15 emu/g) accelerates the extraction process which does not need filtration, centrifuge and precipitation procedures. Under the optimized conditions, the proposed method is applicable for linear range of 1.0–5000.0 μg/L with detection limit of 0.29 μg/L, satisfactory recoveries (≥95.0%) and acceptable repeatability (RSD less than 4.0%). The present study indicates highly promising perspectives of MMOF for highly effective analysis of AMP in complicated matrices.

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Section: Resultsmentioning

confidence: 72%

Section: Introductionmentioning

confidence: 99%

Magnetic metal organic framework for pre-concentration of ampicillin from cow milk samples

Bagheri

Ghaedi

2020

Journal of Pharmaceutical Analysis

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“…One of the explanations for this phenomenon may be that unlike tetracycline, the ampicillin molecule contains a sulfur atom. Therefore, it can be assumed that the rapid and highly effective sorption of ampicillin on the surface of silver (bio) nanoparticles is the result of the high affinity of the sulfur atom to silver ( Figure 2) [61]. The mass, structure and chemical composition of the antibiotics may also correspond to their different sorption efficiencies [62].…”

Section: Kinetics Study Of Antibiotics Sorption Onto Lclb56 Silver (Bmentioning

confidence: 99%

The Influence of Different Forms of Silver on Selected Pathogenic Bacteria

et al. 2020

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The application of silver nanoparticles as an antibacterial agent is becoming more common. Unfortunately, their effect on microorganisms is still not fully understood. Therefore, this paper attempts to investigate the influence of silver ions, biologically synthesized silver nanoparticles and nanoparticles functionalized with antibiotics on molecular bacteria profiles. The initial stage of research was aimed at the mechanism determination involved in antibiotics sorption onto nanoparticles’ surface. For this purpose, the kinetics study was performed. Next, the functionalized formulations were characterized by Fourier transform infrared spectroscopy (FT-IR), dynamic light scattering (DLS) and a zeta potential study. The results reveal that functionalization is a complex process, but does not significantly affect the stability of biocolloids. Furthermore, the antimicrobial assays, in most cases, have shown no increases in antibacterial activity after nanoparticle functionalization, which suggests that the functionalization process does not always generate the improved antimicrobial effect. Finally, the matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) technique was employed to characterize the changes in the molecular profile of bacteria treated with various antibacterial agents. The recorded spectra proved many differences in bacterial lipids and proteins profiles compared to untreated cells. In addition, the statistical analysis of recorded spectra revealed the strain-dependent nature of stress factors on the molecular profile of microorganisms.

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“…The first step that must be taken before removing antibiotic pollutants is to detect their presence. Several methods have been developed including high performance liquid chromatography-mass spectra (HPLC-MS) [4], enzyme-linked immunosorbent assays (ELISA) [5], surface-enhanced Raman scattering (SERS), electrochemistry, and colorimetry [6]. These methods require complicated instruments, high costs, and a long process.…”

Section: Introductionmentioning

confidence: 99%

A Review of Carbon dots (CDs) Application in Sensing and Removing Medical Waste

et al. 2020

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Carbon dots materials (CDs) have the capability in the management of medical waste problem because of its advantage in the detection and degradation of pollutants. The synthesized CDs through various processes and raw materials have been applied to medical wastes, especially antibiotics such as tetracycline (TC), amoxicillin (AMX), para-Nitrophenol (p-NP), doxycycline (DC), ciprofloxacin (CIP), and oxytetracycline (OTC). These antibiotics are detected by utilizing changes in the luminescence property of CDs from the turn-off and turn-on mechanisms. Afterward, the degradation process is conducted using CDs as support materials agent semiconductors in the photosynthesis scheme. In general, CDs can be referred to as multifunction smart materials with the ability to detecting the presence of the antibiotics in simple, sensitive, and selective ways, and potency of medical pollutant removal clearly and effectively.

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Label-free selective detection of ampicillin drug in human urine samples using silver nanoparticles as a colorimetric sensing probe

Abstract: Stable citrate-capped silver nanoparticles (AgNPs) were developed as a colorimetric sensing probe for selective detection of ampicillin in urine samples.

Cited by 60 publications

References 27 publications

Magnetic metal organic framework for pre-concentration of ampicillin from cow milk samples

Magnetic metal organic framework for pre-concentration of ampicillin from cow milk samples

The Influence of Different Forms of Silver on Selected Pathogenic Bacteria

A Review of Carbon dots (CDs) Application in Sensing and Removing Medical Waste

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