Label-free immunosensors based on a novel multi-amplification signal strategy of TiO2-NGO/Au@Pd hetero-nanostructures

Yan, Qin; Cao, Linlin; Dong, Hui; Tan, Zhaoling; Hu, Yitian; Liu, Qing; Liu, Hui; Zhao, Pingping; Chen, Lei; Liu, Yuying; Li, Yueyun; Dong, Yunhui

doi:10.1016/j.bios.2018.12.038

Cited by 45 publications

(19 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…After forming the sandwich immunocomplex, the amperometric signal was measured and the results showed LOQ and LOD values of 0.10 pg/mL and 0.025 pg/mL, respectively, with a 0.1 pg/mL-20 ng/mL linear range. Yan et al fabricated immunosensors using AuNRs and GO to detect HE4Ag [59]. They conjugated titanium oxide nanocluster-functionalized nitrogen-doped rGO with Pd-functionalized AuNR (AuNR@Pd) using silanization and modified electrodes with conjugated composites.…”

Section: Physical Adsorption Of Antibodiesmentioning

confidence: 99%

Recent Progress in Electrochemical Immunosensors

Kim

Park

2021

Biosensors

View full text Add to dashboard Cite

Biosensors used for medical diagnosis work by analyzing physiological fluids. Antibodies have been frequently used as molecular recognition molecules for the specific binding of target analytes from complex biological solutions. Electrochemistry has been introduced for the measurement of quantitative signals from transducer-bound analytes for many reasons, including good sensitivity. Recently, numerous electrochemical immunosensors have been developed and various strategies have been proposed to detect biomarkers. In this paper, the recent progress in electrochemical immunosensors is reviewed. In particular, we focused on the immobilization methods using antibodies for voltammetric, amperometric, impedimetric, and electrochemiluminescent immunosensors.

show abstract

Section: Physical Adsorption Of Antibodiesmentioning

confidence: 99%

Recent Progress in Electrochemical Immunosensors

Kim

Park

2021

Biosensors

View full text Add to dashboard Cite

show abstract

“…Moreover, nanomaterials, such as NPs, carbon nanotubes, or graphene, can act as nanovehicles on the surface of which antibodies or electrochemical labels are coimmobilized, thus improving sensor performance [3]. Various nanomaterials and their nanocomposites have been proposed including gold nanoparticles [51], gold nanorods [52], metal oxide nanofiber [53], nanostructured mineral [54], carbon nano-onions [55] and microporous carbon spheres [56]. Metal–organic frameworks were also reported in the construction of immunosensors in order to encapsulate QDs and form multi-core-shell nanoparticles [50].…”

Section: Electrochemical Sensing Mechanismsmentioning

confidence: 99%

Electrochemical Immunosensors for Antibiotic Detection

Pollap

Kochana

2019

Biosensors

View full text Add to dashboard Cite

Antibiotics are an important class of drugs destined for treatment of bacterial diseases. Misuses and overuses of antibiotics observed over the last decade have led to global problems of bacterial resistance against antibiotics (ABR). One of the crucial actions taken towards limiting the spread of antibiotics and controlling this dangerous phenomenon is the sensitive and accurate determination of antibiotics residues in body fluids, food products, and animals, as well as monitoring their presence in the environment. Immunosensors, a group of biosensors, can be considered an attractive tool because of their simplicity, rapid action, low-cost analysis, and especially, the unique selectivity arising from harnessing the antigen–antibody interaction that is the basis of immunosensor functioning. Herein, we present the recent achievements in the field of electrochemical immunosensors designed to determination of antibiotics.

show abstract

“…Wei et al [72] chose the amino functionalized Co 3 O 4 @MnO 2 -thionine (Co 3 O 4 @MnO 2 -Th) as secondary label, which could greatly enhance the electrochemical response signal in order to develop a sandwich-type electrochemical immunosensor for the determination of alpha fetoprotein (AFP). Titanium oxide nanoclusters functionalized nitrogen-doped reduced graphene oxide (TiO 2 -NGO) decorated by Au@Pd holothurian-shaped nanoparticles (Au@Pd HSs) were used to modify the surface of electrode for the detection of human epididymis specific protein 4 antigen (HE4 Ag) [73]. The perfect catalytical activity to H 2 O 2 of Au@Pd HSs could endow the superior performance to the developed electrochemical immunosensor.…”

Section: Nanomaterials Based Electrochemical Immunosensormentioning

confidence: 99%

“…There are also have several reports regarding electrochemical immunosensors that are based on mental nanomaterials with special morphology. For example, Yuan et al [73] synthesized netlike Au nanostructure using β-cyclodextrins and poly(amidoamine) as platform (Figure 9). The prepared Fc-Fc was absorbed by the β-CD to form Fc-Fc/β-CD/PAMAM−Au, which was attached to the Ab2.…”

Section: Nanomaterials Based Electrochemical Immunosensormentioning

confidence: 99%

See 1 more Smart Citation

Nanomaterials-Based Electrochemical Immunosensors

et al. 2019

View full text Add to dashboard Cite

With the development of nanomaterials and sensor technology, nanomaterials-based electrochemical immunosensors have been widely employed in various fields. Nanomaterials for electrode modification are emerging one after another in order to improve the performance of electrochemical immunosensors. When compared with traditional detection methods, electrochemical immunosensors have the advantages of simplicity, real-time analysis, high sensitivity, miniaturization, rapid detection time, and low cost. Here, we summarize recent developments in electrochemical immunosensors based on nanomaterials, including carbon nanomaterials, metal nanomaterials, and quantum dots. Additionally, we discuss research challenges and future prospects for this field of study.

show abstract

Label-free immunosensors based on a novel multi-amplification signal strategy of TiO2-NGO/Au@Pd hetero-nanostructures

Cited by 45 publications

References 50 publications

Recent Progress in Electrochemical Immunosensors

Recent Progress in Electrochemical Immunosensors

Electrochemical Immunosensors for Antibiotic Detection

Nanomaterials-Based Electrochemical Immunosensors

Contact Info

Product

Resources

About