Labdane-Type Diterpenes Active against Acne from Pine Cones (Pinus densiflora)

Sultan, Md. Zakir; Jeon, Young-Tae; Moon, Surk‐Sik

doi:10.1055/s-2008-1034321

Cited by 32 publications

(16 citation statements)

References 20 publications

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“…A 1 Hz line broadening filter was applied to each FID prior to Fourier transformation. The spectra were manually phased and baseline corrected using the TOPSPIN 3.2 software (Bruker) and calibrated on the central resonance (δ 49.1 ppm) of methanol-d 4 . The 13 C-NMR spectra are provided as supplementary data ( Figure S2).…”

Section: Nmr Chemical Profiling Of the Cpe-generated Fractionsmentioning

confidence: 99%

“…The nonpolar bark extract contains high amount of abietane diterpenes, a category of bioactive compounds which is mainly found in coniferous tree resins. Dehydroabietic acid is the main component of the abietane diterpene content with a plethora of bibliographic references regarding its antibacterial and antifungal properties [4]. On the other hand, several phenolic compounds including stilbenes, lignans, flavonoids, and tannins have been referred in hydrophilic bark extracts [5,6].…”

Section: Introductionmentioning

confidence: 99%

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Bio-Guided Isolation of Methanol-Soluble Metabolites of Common Spruce (Picea abies) Bark by-Products and Investigation of Their Dermo-Cosmetic Properties

et al. 2016

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Abstract:Common spruce (Picea abies L.) is a fast-growing coniferous tree, widely used in several countries for the production of sawn wood, timber and pulp. During this industrial exploitation, large quantities of barks are generated as waste materials. The aim of this study was the bio-guided investigation and the effective recovery of methanol-soluble metabolites of common spruce bark for the development of new dermo-cosmetic agents. The active methanol extract was initially fractionated by Centrifugal Partition Chromatography (CPC) using a triphasic solvent system in a step-gradient elution mode. All resulting fractions were evaluated for their antibacterial activity, antioxidant activity and their capability to inhibit tyrosinase, elastase and collagenase activity. In parallel, the chemical composition of each fraction was established by combining a 13 C-NMR dereplication approach and 2D-NMR analyses. As a result, fourteen secondary metabolites corresponding to stilbene, flavonoid and phenolic acid derivatives were directly identified in the CPC fractions. A high amount (0.93 g) of E-astringin was recovered from 3 g of crude extract in a single 125 min run. E-Astringin significantly induced the tyrosinase activity while E-piceid, taxifolin, and taxifolin-3 -O-glucopyranoside exhibited significant anti-tyrosinase activity. The above compounds showed important anti-collagenase and antimicrobial activities, thus providing new perspectives for potential applications as cosmetic ingredients.

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Section: Nmr Chemical Profiling Of the Cpe-generated Fractionsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Bio-Guided Isolation of Methanol-Soluble Metabolites of Common Spruce (Picea abies) Bark by-Products and Investigation of Their Dermo-Cosmetic Properties

et al. 2016

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“…For cytotoxicity screening, DMSO solutions of the plant extracts were applied against Artemia salina in a 1-day in vivo assay [10,11] The antimicrobial activity of the extractives was determined by the disc diffusion method [12][13][14]. The samples were dissolved separately in solvent (methanol or chloroform) and applied to sterile discs at a concentration of 400 µg/disc and carefully dried to evaporate the residual solvent.…”

Section: Methodsmentioning

confidence: 99%

Preliminary Cytotoxicity and Antimicrobial Investigation of Anthocaphalus chinensis

et al. 2011

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The methanol extract of the stem bark of Anthocephalus chinensis as well as its n-hexane, carbon tetrachloride, chloroform and aqueous soluble fractions were subjected to brine shrimp lethality bioassay and microbiological investigation. In the brine shrimp lethality bioassay, the aqueous soluble partitionate of the methanolic extract revealed the highest cytotoxicity having LC50 of 1.19 mg/ml while in case of antimicrobial screening, the chloroform soluble materials demonstrated moderate inhibition of growth of test organisms. Keywords: Anthocephalus chinensis; Rubiaceae; Cytotoxicity; Antimicrobial. © 2011 JSR Publications. ISSN: 2070-0237 (Print); 2070-0245 (Online). All rights reserved. doi: 10.3329/jsr.v3i3.7529 J. Sci. Res. 3 (3), 689-692 (2011)

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“…Antimicrobial and cytotoxicity assays were carried out according to the methods described in the literatures [3,17,18]. …”

Section: Antimicrobial and Cytotoxicity Assaysmentioning

confidence: 99%

Natural Phthalate Derivatives from the Bacterium Burkholderia cepacia K87

Sultan¹,

Moon

Park

2009

J. Sci. Res.

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In continuation of our screening of antifungal active compounds from the fermentation extracts of soil borne bacteria Burkholderia cepacia K87 afforded three phthalate derivatives, dibutyl phthalate (1), dioctyl phthalate (2), and phthalate ester of alkylated 9-hydroxynonanoic acid (3). Compound 3 was reported first time. These phthalate derivatives were found to be marginally active or inactive against a number of bacteria and fungi.

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Labdane-Type Diterpenes Active against Acne from Pine Cones (Pinus densiflora)

Cited by 32 publications

References 20 publications

Bio-Guided Isolation of Methanol-Soluble Metabolites of Common Spruce (Picea abies) Bark by-Products and Investigation of Their Dermo-Cosmetic Properties

Bio-Guided Isolation of Methanol-Soluble Metabolites of Common Spruce (Picea abies) Bark by-Products and Investigation of Their Dermo-Cosmetic Properties

Preliminary Cytotoxicity and Antimicrobial Investigation of <i>Anthocaphalus chinensis</i>

Natural Phthalate Derivatives from the Bacterium <i>Burkholderia cepacia</i> K87

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