Lab-on-Fiber biosensing for cancer biomarker detection

Ricciardi, Armando; Severino, Renato Souto; Quero, Giuseppe; Carotenuto, Benito; Consales, M.; Crescitelli, A.; Esposito, E.; Ruvo, Menotti; Sandomenico, Annamaria; Borriello, Anna; Giordano, M.; Sansone, Lucia; Granata, C.; Cutolo, A.; Cusano, A.

doi:10.1117/12.2194943

Cited by 10 publications

(8 citation statements)

References 6 publications

(5 reference statements)

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“…Furthermore, a human-Tg sensing probe was developed utilizing the strong LSPR properties of a square lattice of Au nano-pillars realized on a fiber tip. [123] Resonance wavelength shifts of 0.92 nm and 2.82 nm were observed for Tg concentrations of 0.4 μg ml -1 and 4 μg ml -1 , respectively.…”

Section: Periodic Nanostructured Biosensing Applications: Biomolecules Detectionmentioning

confidence: 91%

Advances in Fiber‐Optic Technology for Point‐of‐Care Diagnosis and In Vivo Biosensing

Tabassum

Kumar

2020

Adv Materials Technologies

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Development of reliable, sensitive, selective, and miniaturized sensing technologies is critical for health assessment and early diagnosis and treatment of diseases/anomalies while simultaneously mitigating the challenges associated with in vivo measurements. Some critical constraints to the realization of in vivo measurements include the necessity to fabricate the sensor on a tightly constrained footprint while ensuring acceptable biocompatibility, accuracy, and reliability. The inherent light-guiding properties of optical fibers over long distances, their microscopic cross-section that can be structured at the nanoscale to manipulate the light transmittance/reflectance spectrum, excellent biocompatibility enabling their efficient integration with bio-recognition molecules, immunity to electromagnetic interference, mechanical flexibility, and low cost have been inviting research attention to utilize these unique features for in vivo and label-free point-ofcare diagnostics. Hence, fiber-optic biosensing has become a promising research thrust, with a plethora of emerging methodologies to develop ultrasensitive and selective sensing probes.A unified presentation of the research trends on biosensors incorporated into optical fibers is presented.

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Section: Periodic Nanostructured Biosensing Applications: Biomolecules Detectionmentioning

confidence: 91%

Advances in Fiber‐Optic Technology for Point‐of‐Care Diagnosis and In Vivo Biosensing

Tabassum

Kumar

2020

Adv Materials Technologies

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“…Charge dissipation issue imposed by the electrically insulating nature of silica glass constituting the fibers, has been overcome by depositing onto the resist surface sacrificial layers such as conducting polymers or metals . The patterned resist can be used as an active part of optical components , or it can serve as sacrificial layer for subsequent etching or lift‐off procedures .…”

Section: Lab On Tipmentioning

confidence: 99%

“…With a similar approach, Ricciardi et al. demonstrated an optical fiber biosensor for detecting human thyroglobulin (Tg) at nanomolar concentrations . This biosensor consists of a chromium‐gold pillars array supporting LSPRs in the NIR.…”

Section: Lab On Tipmentioning

confidence: 99%

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Lab on Fiber Technology for biological sensing applications

Vaiano

Carotenuto

Pisco

et al. 2016

Laser & Photonics Reviews

237

155

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This review presents an overview of “Lab on Fiber” technologies and devices with special focus on the design and development of advanced fiber optic nanoprobes for biological applications. Depending on the specific location where functional materials at micro and nanoscale are integrated, “Lab on Fiber Technology” is classified into three main paradigms: Lab on Tip (where functional materials are integrated onto the optical fiber tip), Lab around Fiber (where functional materials are integrated on the outer surface of optical fibers), and Lab in Fiber (where functional materials are integrated within the holey structure of specialty optical fibers). This work reviews the strategies, the main achievements and related devices developed in the “Lab on Fiber” roadmap, discussing perspectives and challenges that lie ahead, with special focus on biological sensing applications.

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“…14 Moreover, by using EBL and RIE or a lift-off process, ordered arrays of gold pillars have been fabricated on the fiber. 33,36,51 The lift-off 36,51 or RIE 33 processes were used to remove the sacrificial e-beam resist in order to obtain the desired gold pillar design onto the fiber tips. Although the direct top-down methodology allows production of repeatable patterns, it remains an expensive approach.…”

Section: Introductionmentioning

confidence: 99%

Lab-on-fiber technology: a new vision for chemical and biological sensing

Ricciardi

Crescitelli

Vaiano

et al. 2015

Analyst

178

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The integration of microfluidics and photonic biosensors has allowed achievement of several laboratory functions in a single chip, leading to the development of photonic lab-on-a-chip technology. Although a lot of progress has been made to implement such sensors in small and easy-to-use systems, many applications such as point-of-care diagnostics and in vivo biosensing still require a sensor probe able to perform measurements at precise locations that are often hard to reach. The intrinsic property of optical fibers to conduct light to a remote location makes them an ideal platform to meet this demand. The motivation to combine the good performance of photonic biosensors on chips with the unique advantages of optical fibers has thus led to the development of the so-called lab-on-fiber technology. This emerging technology envisages the integration of functionalized materials on micro- and nano-scales (i.e. the labs) with optical fibers to realize miniaturized and advanced all-in-fiber probes, especially useful for (but not limited to) label-free chemical and biological applications. This review presents a broad overview of lab-on-fiber biosensors, with particular reference to lab-on-tip platforms, where the labs are integrated on the optical fiber facet. Light-matter interaction on the fiber tip is achieved through the integration of thin layers of nanoparticles or nanostructures supporting resonant modes, both plasmonic and photonic, highly sensitive to local modifications of the surrounding environment. According to the physical principle that is exploited, different configurations - such as localized plasmon resonance probes, surface enhanced Raman scattering probes and photonic probes - are classified, while various applications are presented in context throughout. For each device, the surface chemistry and the related functionalization protocols are reviewed. Moreover, the implementation strategies and fabrication processes, either based on bottom-up or top-down approaches, are discussed. In conclusion we highlight some of the further development opportunities, including lab-in-a-needle technology, which could have a direct and disruptive impact in localized cancer treatment applications.

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Lab-on-Fiber biosensing for cancer biomarker detection

Cited by 10 publications

References 6 publications

Advances in Fiber‐Optic Technology for Point‐of‐Care Diagnosis and In Vivo Biosensing

Advances in Fiber‐Optic Technology for Point‐of‐Care Diagnosis and In Vivo Biosensing

Lab on Fiber Technology for biological sensing applications

Lab-on-fiber technology: a new vision for chemical and biological sensing

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