Lab-in-a-Tube: Detection of Individual Mouse Cells for Analysis in Flexible Split-Wall Microtube Resonator Sensors

Smith, Elliot J.; Schulze, Sabine; Kiravittaya, Suwit; Mei, Yongfeng; Sánchez, Samuel; Schmidt, Oliver G.

doi:10.1021/nl1036148

Cited by 111 publications

(108 citation statements)

References 36 publications

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“…[32] Photolithography was first utilized to prepare U-shaped photoresist (ARP-3510) pattern as a sacrificial layer on a silicon substrate. Angle deposition was applied to grow strained SiO/SiO 2 (≈8/42 nm) nanomembrane bilayer with deposition rate ≈5 and ≈0.5 Å s −1 respectively via electron-beam evaporation method.…”

Section: Methodsmentioning

confidence: 99%

“…[24][25][26][27] These key merits enable extensive applications ranging from optofluidic sensing, [28][29][30][31] single cell analysis, [32] dynamic molecular process detection, [33] photon plasmon coupling, [34] to optical spin-orbit coupling. [35] To combine with other media/objects, luminescent quantum dots, [36,37] quantum wells, [38] and organic molecules [39] have been enwrapped into the microtube wall by the rolling up process, which couple photoluminescence (PL) light to the microtube cavities to support whisperinggallery mode (WGM) resonances.…”

Section: Strong Coupling In a Photonic Molecule Formed By Trapping A mentioning

confidence: 99%

“…[32] Figure 2a shows an optical image of a rolledup microtube. The outer diameter of the microtube is ≈10.8 µm and the wall thickness is ≈140 nm.…”

Section: Fabrication and Characterizationsmentioning

confidence: 99%

mentioning

confidence: 99%

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Strong Coupling in a Photonic Molecule Formed by Trapping a Microsphere in a Microtube Cavity

Wang

Yin

et al. 2017

Advanced Optical Materials

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role for the efficient intercavity coupling. However, the evanescent field is relatively weak in the reported photonic mole cules because most of the optical field is strongly confined within the coupled cavities (e.g., microdisks, [4,8,11,18] micro toroids, [19] microspheres, [3] microrods, [5,20] and microfibers [7] ). As such, one needs a deliberate control on both the cavity geometries and the intercavity coupling gap to ensure a good spectral match and efficient evanescent coupling between the coupled cavities. [18] Moreover, dynamic tuning of the intercavity coupling strength has been investigated in recent years, which were carried out by advanced and sophisticated techniques such as strain tuning, [21,22] acoustooptic control, [23] and precise micromanipulation techniques. [3] To extend and promote the research in the field of photonic molecules, it is of high interest to design novel photonic molecules extending from adjacent solid microcavities to thinwalled hollow cavities which possess intense evanescent field facilitating intercavity coupling and provide novel strategy for tuning of the coupling strength.Microtube cavities, which are formed by selfrolling of pre strained nanomembranes, feature unique properties such as hollowcore structures and ultrathin cavity walls (≈100-300 nm) for the study of lightmatter interactions and the integration of "labinatube" systems. [24][25][26][27] These key merits enable extensive applications ranging from optofluidic sensing, [28][29][30][31] single cell analysis, [32] dynamic molecular process detection, [33] photon plasmon coupling, [34] to optical spin-orbit coupling.[35] To combine with other media/objects, luminescent quantum dots, [36,37] quantum wells, [38] and organic molecules [39] have been enwrapped into the microtube wall by the rolling up process, which couple photoluminescence (PL) light to the microtube cavities to support whisperinggallery mode (WGM) resonances. [37,40] In this context, a design and demonstration of photonic molecule based on microtube cavity is of fundamental interest for the study of strong optical coupling and the promo tion of its potential applications.Herein, we report a novel design of photonic molecule by trapping a microsphere cavity into the hollow core of a rolled up microtube cavity. We focus on studying the WGM coupling between the trapped microsphere and microtube cavity with a significant difference of cavity sizes, which is in contrast to pre vious reports where the two externally adjacent microcavities possess highly similar sizes [11,12,41] or slightly mismatched sizes (less than two times). [4][5][6][7]18,[42][43][44] Periodic modulations on A photonic molecule formed by trapping a microsphere cavity into a hollow microtube cavity is demonstrated, which provides a novel design over conventional photonic molecules comprised of solid-core whispering gallery mode microcavities with externally tangent configuration. Periodic spectral modulations of mode intensity, resonant mode shift, and quality factor are observed...

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Section: Methodsmentioning

confidence: 99%

Section: Strong Coupling In a Photonic Molecule Formed By Trapping A mentioning

confidence: 99%

“…[32] Figure 2a shows an optical image of a rolledup microtube. The outer diameter of the microtube is ≈10.8 µm and the wall thickness is ≈140 nm.…”

Section: Fabrication and Characterizationsmentioning

confidence: 99%

mentioning

confidence: 99%

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Strong Coupling in a Photonic Molecule Formed by Trapping a Microsphere in a Microtube Cavity

Wang

Yin

et al. 2017

Advanced Optical Materials

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“…Whispering-gallery mode (WGM) resonators have been demonstrated as highly sensitive detectors for humidity [1], UV light [2], single cells [3], or nanoparticles [4]. Especially the field of biosensing has been investigated in detail during the past years [5].…”

Section: Introductionmentioning

confidence: 99%

Efficient free-space read-out of WGM lasers using circular micromirrors

Wienhold¹,

Kraemmer²,

Bacher³

et al. 2015

Opt. Express

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Abstract:Lasing from whispering-gallery mode (WGM) resonators occurs omnidirectional in azimuthal plane. Most applications of WGM resonators require spectral analysis with off-chip detectors, where in-plane emission and beam divergence hinder efficient detection. We demonstrate redirecting WGM laser emission from all azimuthal angles using a circular micromirror placed around the cavity. By collecting reflections off the micromirror via free-space optics, read-out intensity improved by one order of magnitude. Blocking vertically emitted spontaneous emission and recording reflections off the micromirror only, signal-to-noise ratio improved from 4.6 dB to 15 dB. Our read-out concept may be applied to arbitrary WGM cavity geometries without deteriorating the cavity's quality factor.

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