La méningite purulente en milieu hospitalier pédiatrique à Dakar (Sénégal)

Camara, B.; Cisse, M. F.; Faye, P.M.; Bâ, M.; Tall-Dia, A; Diouf, S.; Diagne, Ibrahima; Diagne, N.R Gueye; Ba, A.; Gueye, Arona; Sow, Doudou; Kuakuvi, N

doi:10.1016/s0399-077x(03)00221-x

Cited by 9 publications

(3 citation statements)

References 11 publications

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“…A study conducted in Senegal in 2003 reported a hospital frequency of 4.9%. [2] This now reflects the regression of PCM. A male predominance was noted (sex ratio = 2.33).…”

Section: Discussionmentioning

confidence: 76%

“…This result is in line with other studies carried out in Senegal with a sex ratio of 1.27. [2,3] However, other studies reported a female predominance. [4,5] There is therefore no direct relationship between the occurrence of PM and gender.…”

Section: Discussionmentioning

confidence: 99%

“…The results of our study are consistent with those of the literature. [2,6,7] The predominance of low social strata can be explained by overcrowding, unfavorable lifestyle in this group, as well as lack of vaccination or incomplete vaccination status in some cases. The proportion of children with an up-todate vaccination status was therefore much higher than that of children whose vaccination status was not up to date.…”

Section: Discussionmentioning

confidence: 99%

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Purulent Meningitis in Children: A Retrospective Study of 70 Cases in Senegal

Basse¹,

Faye²,

Sow³

et al. 2020

IJIDT

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Introduction: Despite much progress, purulent childhood meningitis (PCM) remains a public health problem. The objective of this work was to determine the epidemiological, clinical, therapeutic and evolutionary profile of purulent meningitis in children. Methods: Based on retrospective work carried out over a 4-year period (01 January 2014 to 31 December 2017), we studied the epidemiological, clinical, therapeutic and evolutionary aspects of cases of purulent meningitis hospitalized in the pediatric ward of the Children's Hospital of Diamniadio. Included were all children from 29 days to 15 years of age in whom the diagnosis of purulent meningitis was confirmed by the laboratory. Results: The hospital frequency was 1.9%. The mean age of the patients was 41.0 months. Among the affected children, 68.6% were fully vaccinated. The main germ was Neisseria meningitidis W135 (58.8%). Third generation cephalosporins were the antibiotics of choice (97.1%). No resistance was found to them. The cure rate with sequelae was 5.7%. Streptococcus pneumoniae was the germ responsible for 50% of the objective sequelae. The mortality rate was 7.1%. Conclusion: Neisseria meningitidis W135 is the main germ of purulent meningitis in our study. It is not included in the national routine immunization. It is imperative to adapt vaccination to the epidemiological fluctuation of pathogens in our regions.

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“…A study conducted in Senegal in 2003 reported a hospital frequency of 4.9%. [2] This now reflects the regression of PCM. A male predominance was noted (sex ratio = 2.33).…”

Section: Discussionmentioning

confidence: 76%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Purulent Meningitis in Children: A Retrospective Study of 70 Cases in Senegal

Basse¹,

Faye²,

Sow³

et al. 2020

IJIDT

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Morbi-mortalité en milieu hospitalier pédiatrique dakarois (Sénégal)

Camara

Diouf

Faye

et al. 2005

Archives de Pédiatrie

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Antimicrobial resistance in West Africa: a systematic review and meta-analysis

Bernabé

Langendorf²,

Ford

et al. 2017

International Journal of Antimicrobial Agents

121

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Growing data suggest that antimicrobial-resistant bacterial infections are common in low- and middle-income countries. This review summarises the microbiology of key bacterial syndromes encountered in West Africa and estimates the prevalence of antimicrobial resistance (AMR) that could compromise first-line empirical treatment. We systematically searched for studies reporting on the epidemiology of bacterial infection and prevalence of AMR in West Africa within key clinical syndromes. Within each syndrome, the pooled proportion and 95% confidence interval were calculated for each pathogen-antibiotic pair using random-effects models. Among 281 full-text articles reviewed, 120 met the eligibility criteria. The majority of studies originated from Nigeria (70; 58.3%), Ghana (15; 12.5%) and Senegal (15; 12.5%). Overall, 43 studies (35.8%) focused on urinary tract infections (UTI), 38 (31.7%) on bloodstream infections (BSI), 27 (22.5%) on meningitis, 7 (5.8%) on diarrhoea and 5 (4.2%) on pneumonia. Children comprised the majority of subjects. Studies of UTI reported moderate to high rates of AMR to commonly used antibiotics including evidence of the emergence of cephalosporin resistance. We found moderate rates of AMR among common bloodstream pathogens to typical first-line antibiotics including ampicillin, cotrimoxazole, gentamicin and amoxicillin/clavulanate. Among S. pneumoniae strains isolated in patients with meningitis, levels of penicillin resistance were low to moderate with no significant resistance noted to ceftriaxone or cefotaxime. AMR was common in this region, particularly in hospitalized patients with BSI and both outpatient and hospitalized patients with UTI. This raises concern given the limited diagnostic capability and second-line treatment options in the public sector in West Africa.

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La méningite purulente en milieu hospitalier pédiatrique à Dakar (Sénégal)

Cited by 9 publications

References 11 publications

Purulent Meningitis in Children: A Retrospective Study of 70 Cases in Senegal

Purulent Meningitis in Children: A Retrospective Study of 70 Cases in Senegal

Morbi-mortalité en milieu hospitalier pédiatrique dakarois (Sénégal)

Antimicrobial resistance in West Africa: a systematic review and meta-analysis

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