La atención sostenida en la fase preclínica de la enfermedad de Alzheimer

Estévez-González, A; García‐Sánchez, Carmen; Boltes, Anunciación; García-Nonell, C; Rigau-Ratera, E; Otermín, Pilar; Gironell, Alexandre; Kulisevsky, J

doi:10.33588/rn.3609.2002613

Cited by 10 publications

(5 citation statements)

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“…The vast majority of studies of cognitive changes in the preclinical phase of AD have reported the presence of subtle memory changes as the key identifying characteristic of this stage (Backman et al, 2001;Estévez-Gonzalez et al, 2003;Lange et al, 2002;Small et al, 2000). However, recent studies have found that other cognitive functions, including attention (Estévez-Gonzalez et al, 2003), executive functions (Rapp & Reischies, 2005), visuospatial skills (Small et al, 1997), and language (Garrard et al, 2005), begin to deteriorate many years before the person enters the clinical stage of the disease.…”

Section: Discussionmentioning

confidence: 97%

“…However, recent studies have found that other cognitive functions, including attention (Estévez-Gonzalez et al, 2003), executive functions (Rapp & Reischies, 2005), visuospatial skills (Small et al, 1997), and language (Garrard et al, 2005), begin to deteriorate many years before the person enters the clinical stage of the disease. Some studies have found large discrepancies in a preclinical AD population in the scores of two tests: naming and visuoconstruction skills (Jacobson et al, 2002).…”

Section: Discussionmentioning

confidence: 98%

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Linguistic changes in verbal expression: A preclinical marker of Alzheimer's disease

Cuetos

Arango‐Lasprilla

Uribe

et al. 2007

J. Inter. Neuropsych. Soc.

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Despite the many studies examining linguistic deterioration in Alzheimer's disease (AD), very little is known about changes in verbal expression during the preclinical phase of this disease. The objective of this study was to determine whether changes in verbal expression occur in the preclinical phase of AD. The sample consisted of 40 healthy Spanish speakers from Antioquia, Colombia. A total of 19 were carriers of the E280A mutation in the Presenilin 1 gene, and 21 were noncarrier family members. The two groups were similar in age and education. All the participants were shown the Cookie Theft Picture Card from the Boston Diagnostic Aphasia Examination and were asked to describe the scene. Specific grammatical and semantic variables were evaluated. The performance of each group was compared using multivariate analyses of the variance for semantic and grammatical variables, and errors. Carriers of the mutation produced fewer semantic categories than noncarriers. In the preclinical phase of AD, changes in verbal expression are apparent and early detection of these differences may assist the early diagnosis of and intervention in this disease.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 98%

Linguistic changes in verbal expression: A preclinical marker of Alzheimer's disease

Cuetos

Arango‐Lasprilla

Uribe

et al. 2007

J. Inter. Neuropsych. Soc.

View full text Add to dashboard Cite

show abstract

“…The earliest clinical symptom of AD is usually impaired episodic memory [42][43][44][45]. Individuals with memory distortions (impairment of memory and recognition) and classified as pre-amnestic MCI and no underlying medical conditions that could explain these cognitive impairments (such as cerebrovascular disease, anxiety, stress or depression) have an 8.5-fold increased risk of progression to dementia (mainly AD) compared to those classified as possible-naMCI [46,47].…”

Section: Introductionmentioning

confidence: 99%

Neurobiological Highlights of Cognitive Impairment in Psychiatric Disorders

Morozova

Zorkina

Abramova

et al. 2022

IJMS

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This review is focused on several psychiatric disorders in which cognitive impairment is a major component of the disease, influencing life quality. There are plenty of data proving that cognitive impairment accompanies and even underlies some psychiatric disorders. In addition, sources provide information on the biological background of cognitive problems associated with mental illness. This scientific review aims to summarize the current knowledge about neurobiological mechanisms of cognitive impairment in people with schizophrenia, depression, mild cognitive impairment and dementia (including Alzheimer’s disease).The review provides data about the prevalence of cognitive impairment in people with mental illness and associated biological markers.

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“…Finalmente, este estudio proporciona datos nor mativos que podrían ser utilizados para la investi gación relacionada con el papel de la atención y la memoria de trabajo en diferentes trastornos psico patológicos y del neurodesarrollo. En este sentido, la tarea de CPT se ha usado para estudiar la enfer medad de Alzheimer [10,11], la enfermedad de Par kinson [12], la discalculia [13,14] y el TDAH [15,16]. En cuanto a la psicopatología, un diseño similar se ha utilizado para estudiar el trastorno bipolar [9].…”

Section: Discussionunclassified

“…Esta tarea fue inicialmente diseñada para detectar los déficits atencionales en pacientes con diagnóstico de esqui zofrenia o depresión. Posteriormente, se ha utiliza do para estudiar los déficits cognitivos en patolo gías como el trastorno bipolar [9], la enfermedad de Alzheimer [10,11], la enfermedad de Parkinson [12], la discalculia [13,14] y, especialmente, el trastorno por déficit de atención/hiperactividad (TDAH) [15,16]. Sin embargo, la localización específica y la dis tribución relativa de las activaciones de las redes identificadas con resonancia magnética funcional durante la ejecución del CPT varían significativamen te según el diseño de la tarea [17,18].…”

Section: Sujetos Y Métodosunclassified

Bases cerebrales de la atención sostenida y la memoria de trabajo: un estudio de resonancia magnética funcional basado en el Continuous Performance Test

Bartés-Serrallonga¹,

Adán²,

Solé-Casals³

et al. 2014

RevNeurol

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Introduction. One of the most used paradigms in the study of attention is the Continuous Performance Test (CPT). The identical pairs version (CPT-IP) has been widely used to evaluate attention deficits in developmental, neurological and psychiatric disorders. However, the specific locations and the relative distribution of brain activation in networks identified with functional imaging, varies significantly with differences in task design. Aim. To design a task to evaluate sustained attention using functional magnetic resonance imaging (fMRI), and thus to provide data for research concerned with the role of these functions. Subjects and methods. Forty right-handed, healthy students (50% women; age range: 18-25 years) were recruited. A CPT-IP implemented as a block design was used to assess sustained attention during the fMRI session. Results. The behavioural results from the CPT-IP task showed a good performance in all subjects, higher than 80% of hits. fMRI results showed that the used CPT-IP task activates a network of frontal, parietal and occipital areas, and that these are related to executive and attentional functions. Conclusions. In relation to the use of the CPT to study of attention and working memory, this task provides normative data in healthy adults, and it could be useful to evaluate disorders which have attentional and working memory deficits.

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La atención sostenida en la fase preclínica de la enfermedad de Alzheimer

Cited by 10 publications

References 0 publications

Linguistic changes in verbal expression: A preclinical marker of Alzheimer's disease

Linguistic changes in verbal expression: A preclinical marker of Alzheimer's disease

Neurobiological Highlights of Cognitive Impairment in Psychiatric Disorders

Bases cerebrales de la atención sostenida y la memoria de trabajo: un estudio de resonancia magnética funcional basado en el Continuous Performance Test

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