L0009 Pain hypersensitivity induced by paradoxical sleep deprivation is not due to altered binding to brain μ-opioid receptors

Nascimento, Danielle C.; Andersen, M.L.; Hipólide, Débora Cristina; Nóbrega, José N.; Tufík, S.

doi:10.1016/s1389-9457(07)70379-9

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“…Numerous studies have investigated the impact of experimental sleep disturbances on pain perception ( Moldofsky, 1995 ; Iaboni and Moldofsky, 2008 ; Finan et al, 2013 ; Schrimpf et al, 2015 ), and despite highly heterogeneous SD protocols, the overall results point to an increase in pain responses and behaviors when the sleep is disturbed in otherwise healthy humans, rats, or mice. Studies in rodents show that sleep loss either in the form of total sleep ( Alexandre et al, 2020 ) or rapid eye movement (REM) sleep loss ( Nascimento et al, 2007 ; Skinner et al, 2011 ) not only increases pain perception, but also decreases the analgesic efficacy of opioids. Furthermore, sleep apnea which is commonly experienced by opioid users, that also results in fragmented sleep, and may be an additional risk factor in developing opioid tolerance, OUD and susceptibility to relapse ( Doufas et al, 2013 ; Jaoude et al, 2016 ; Ardon et al, 2020 ).…”

Section: Sleep Loss/deprivation As a Modulator Of The Opioid Mediated...mentioning

confidence: 99%

Opioids, sleep, analgesia and respiratory depression: Their convergence on Mu (μ)-opioid receptors in the parabrachial area

et al. 2023

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Opioids provide analgesia, as well as modulate sleep and respiration, all by possibly acting on the μ-opioid receptors (MOR). MOR’s are ubiquitously present throughout the brain, posing a challenge for understanding the precise anatomical substrates that mediate opioid induced respiratory depression (OIRD) that ultimately kills most users. Sleep is a major modulator not only of pain perception, but also for changing the efficacy of opioids as analgesics. Therefore, sleep disturbances are major risk factors for developing opioid overuse, withdrawal, poor treatment response for pain, and addiction relapse. Despite challenges to resolve the neural substrates of respiratory malfunctions during opioid overdose, two main areas, the pre-Bötzinger complex (preBötC) in the medulla and the parabrachial (PB) complex have been implicated in regulating respiratory depression. More recent studies suggest that it is mediation by the PB that causes OIRD. The PB also act as a major node in the upper brain stem that not only receives input from the chemosensory areas in medulla, but also receives nociceptive information from spinal cord. We have previously shown that the PB neurons play an important role in mediating arousal from sleep in response to hypercapnia by its projections to the forebrain arousal centers, and it may also act as a major relay for the pain stimuli. However, due to heterogeneity of cells in the PB, their precise roles in regulating, sleep, analgesia, and respiratory depression, needs addressing. This review sheds light on interactions between sleep and pain, along with dissecting the elements that adversely affects respiration.

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Section: Sleep Loss/deprivation As a Modulator Of The Opioid Mediated...mentioning

confidence: 99%

Opioids, sleep, analgesia and respiratory depression: Their convergence on Mu (μ)-opioid receptors in the parabrachial area

et al. 2023

View full text Add to dashboard Cite

show abstract

L0009 Pain hypersensitivity induced by paradoxical sleep deprivation is not due to altered binding to brain μ-opioid receptors

Cited by 1 publication

References 0 publications

Opioids, sleep, analgesia and respiratory depression: Their convergence on Mu (μ)-opioid receptors in the parabrachial area

Opioids, sleep, analgesia and respiratory depression: Their convergence on Mu (μ)-opioid receptors in the parabrachial area

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