L’élimination des cellules sénescentes : vers un avenir meilleur ?

Chauvet, Véronique; Jouaville, Soukie; Garbez, Nicolas; Martins, Isabelle

doi:10.1051/medsci/20163211023

Cited by 1 publication

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“…En présence de ganciclovir, un antiviral ciblant les herpès virus, les cellules exprimant cette thymidine kinase meurent rapidement. Le second modèle, appelé INK-ATTAC (INK-linked apoptosis through targeted activation of caspase) [38] (➜), consiste en l'expression sous le contrôle du promoteur du gène codant p16 INK4a , de la luciférase et du gène « suicide » de la caspase 8, activable après addition de la molécule AP20187 (B/B homodimerizer). Ces deux modèles permettent à la fois la détection des cellules sénescentes dans l'animal anesthésié, sous caméra CCD (charge-coupled device) en présence de luciférine, et leur…”

Section: Accumulation De Cellules Sénescentes Au Cours Du Vieillissementunclassified

Cibler les cellules sénescentes

et al. 2018

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Our societies are facing with the emergence of an exponential number of patients with age-related degenerative chronic diseases such as osteoarthritis or osteoporosis. The "better" aging will thus be at the center of the next medical challenges in order to delay the loss of independence of the elderly and reduce costs of our health services. Over the last 5 years, based on innovative mouse models or in vitro studies, several research teams have demonstrated that many age-related degenerative diseases have in common a deleterious accumulation of so-called senescent cells in their respective deficient tissues. Thus, under the concept of senolysis, it has been proposed to target pharmacologically in vivo these cells to eliminate them and thus delay the emergence of these chronic diseases of the elderly subject. We propose here to summarize the recent strategies applied for the identification of novel senolytics and their uses in osteoarthritis and osteoporosis therapies.

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Section: Accumulation De Cellules Sénescentes Au Cours Du Vieillissementunclassified