volume 9, issue 1, P107-114 2016
DOI: 10.15283/ijsc.2016.9.1.107
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Abstract: Background and ObjectivesHuman mesenchymal stem cells (hMSCs) are attractive candidates for cell therapy and regenerative medicine due to their multipotency and ready availability, but their application can be complicated by the factors such as age of the donors and senescence-associated growth arrest during culture conditions. The latter most likely reflects the fact that aging of hMSCs is associated with a rise in intracellular reactive oxygen species, loss of telomerase activity, decrease in human telomeras…

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