Abstract:Interleukin 1β (IL‐1β) is a proinflammatory cytokine that is normally expressed and released by monocytes in response to infection and injury. Chronic expression of IL‐1β has been associated with numerous inflammatory diseases. We previously reported chromatin looping for the IL1B gene that is mediated by a mutual DNA‐binding domain (DBD) interaction between two transcription factors, Spi‐1/PU.1 (Spi‐1) at the promoter and C/EBPβ at a distal enhancer. The nature of this critical interaction between the Spi‐1 w… Show more
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