Kutane Lymphome

Abstract

Cutaneous lymphomas are a heterogeneous group of clonal proliferations of T and B lymphocytes with various clinical manifestations and prognosis. The new EORTC WHO classification of cutaneous T- and B-cell lymphomas provides a uniform nomenclature based on clinical, histologic, cytologic and molecular biological features. Accurate classification is a prerequisite for uniform therapeutic concepts. For office-based dermatologist, more than 50% of the therapies deal with classic forms of cutaneous T-cell lymphomas, type mycosis fungoides. In recent years the paradigm for the therapy of cutaneous T-cell lymphomas has changed. Since early aggressive treatment with cytostatic agents does not increase the response rate or overall survival, a commonly accepted stage-adapted therapy is recommended. In this review the current status of the therapy of cutaneous lymphoma is described in detail.

Kutane Lymphome 2008

“…Das Verständnis in der Pathogenese kutaner T−Zell−Lymphome ist in den letzten Jahren substanziell gewachsen [6,18,26,31]. Dennoch ist die Ursache und der Zeitpunkt der malignen Trans− formation stimulierter T−Lymphozyten in ein genuines T−Zell− Lymphom nicht bekannt.…”