Korean Red Ginseng attenuates ethanol-induced steatosis and oxidative stress via AMPK/Sirt1 activation

Han, Jae Yun; Lee, Sangkyu; Yang, Ji Hye; Kim, Sun-Ju; Sim, Juhee; Kim, Mi Gwang; Jeong, Tae Cheon; Ku, Sae Kwang; Cho, Il Je; Ki, Sung Hwan

doi:10.1016/j.jgr.2014.09.001

Cited by 60 publications

(42 citation statements)

References 36 publications

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“…Chronic alcohol exposure impairs adenosine monophosphate‐activated protein kinase (AMPK)/sirtuin 1 (Sirt1) axis, which is involved in regulating energy metabolism (You, Liang, Ajmo, & Ness, ; You, Matsumoto, Pacold, Cho, & Crabb, ) Ginsenoside Rb2 and Rd supplementation inhibited fat accumulation induced by ethanol. Accordingly, Rb2 and Rd effectively rescued ethanol‐induced suppression of Sirt1 and PPARα (Han et al, ).…”

Section: Natural Compounds Beneficial For Ald Treatmentmentioning

confidence: 99%

Natural compounds in the chemoprevention of alcoholic liver disease

Zhu

Wang

et al. 2019

Phytotherapy Research

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Alcoholic liver disease (ALD), caused by excessive consumption of alcohol, is a major cause of chronic liver disease worldwide. Much effort has been expended to explore the pathogenesis of ALD. Hepatic cell injury, oxidative stress, inflammation, regeneration, and bacterial translocation are all involved in the pathogenesis of ALD. Immediate abstinence is the most important therapeutic treatment for affected individuals. However, the medical treatment for ALD had not advanced in a long period. Intriguingly, an increasing body of research indicates the potential of natural compounds in the targeted therapy of ALD. A plethora of dietary natural products such as flavonoids, resveratrol, saponins, and β‐carotene are found to exert protective effects on ALD. This occurs through various mechanisms composed of antioxidative, anti‐inflammatory, iron chelation, pro‐apoptosis, and/or antiproliferation of hepatic stellate cells and hepatocellular carcinoma cells. In this review, we will summarize current knowledge about the pathogenesis and treatments of ALD and focus on the potential of natural compounds in ALD therapies and underlying mechanisms.

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Section: Natural Compounds Beneficial For Ald Treatmentmentioning

confidence: 99%

Natural compounds in the chemoprevention of alcoholic liver disease

Zhu

Wang

et al. 2019

Phytotherapy Research

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“…Inhibition of hsp90 by 17-dimethylamino-ethylamino-17-demethoxygeldanamycin ameliorated the steatosis and liver inflammation induced by chronic-plus-binge ethanol feeding, which suggests that hsp90 is a promising therapeutic target for the treatment of ALD 96 . More recently, the chronic-plus-binge ethanol feeding model has also been used to test the therapeutic potential of many drugs/compounds, including a CB2 agonist 62 , betulin (a triterpene from the bark of Betula platyphylla Suk) 97 , luteolin (a flavonoid) 98 , Lactobacillus rhamnosus GG 99 , Korean Red Ginseng 100 , glycycoumarin (a representative coumarin from traditional Chinese Medicine licorice) 101 , flaxseed oil enriched in α-linolenic acid (a plant-derived n-3 polyunsaturated fatty acid) 102 , thymoquinone (a biologically active compound isolated from the seeds of Nigella sativa L.) 103 , and β-caryophyllene (BCP: a plant-derived FDA-approved food additive with anti-inflammatory properties) 104 . The data from these studies revealed that treatment with all of these components ameliorated the chronic-plus-binge alcohol-induced liver inflammation and steatosis in mice.…”

Section: Application Of Chronic-plus-binge Ethanol Model In Testing Tmentioning

confidence: 99%

Animal Models of Alcoholic Liver Disease: Pathogenesis and Clinical Relevance

et al. 2017

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Alcoholic liver disease (ALD), a leading cause of chronic liver injury worldwide, comprises a range of disorders including simple steatosis, steatohepatitis, cirrhosis, and hepatocellular carcinoma. Over the last five decades, many animal models that have been useful for the study of ALD pathogenesis have been developed. Recently, a chronic-plus-binge ethanol feeding model was reported. This model induces significant steatosis, hepatic neutrophil infiltration, and liver injury. A clinically relevant model of high-fat diet feeding plus binge ethanol was also developed, which highlights the risk of excessive binge drinking in obese/overweight individuals. All of these models recapitulate some features of the different stages of ALD and have been widely used by many investigators to study the pathogenesis of ALD and test therapeutic drugs/components. However, these models are somewhat variable, depending on mouse genetic background, ethanol dose, and animal facility environment. This review focuses on these models and discusses these variations and some methods to improve the feeding protocol. The pathogenesis, clinical relevance, and translational studies of these models are also discussed.

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“…Red ginseng extract improves chronic alcohol-induced histopathological changes of liver in mice. This extract also inhibits oxidative stress and lipid peroxidation by reducing the formation of 4-HNE and the number of 4-HNE-positive cells and protects hepatocytes from inflammation and necrosis by activating AMP-activated protein kinase (AMPK)/Sirt1 pathway [82]. Recently, black ginseng extract has been reported to maintain the cellular redox status by restoring NOX and GSH level change and alleviate oxidative stress by reducing intracellular ROS production and lipid peroxide 4-HNE signals, resulting in the protection of hydrogen peroxide-induced oxidative damage in AML-12 cells [83].…”

Section: Protection Against Liver Injurymentioning

confidence: 99%

Can Medicinal Plants and Bioactive Compounds Combat Lipid Peroxidation Product 4-HNE-Induced Deleterious Effects?

Wang

et al. 2020

Biomolecules

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The toxic reactive aldehyde 4-hydroxynonenal (4-HNE) belongs to the advanced lipid peroxidation end products. Accumulation of 4-HNE and formation of 4-HNE adducts induced by redox imbalance participate in several cytotoxic processes, which contribute to the pathogenesis and progression of oxidative stress-related human disorders. Medicinal plants and bioactive natural compounds are suggested to be attractive sources of potential agents to mitigate oxidative stress, but little is known about the therapeutic potentials especially on combating 4-HNE-induced deleterious effects. Of note, some investigations clarify the attenuation of medicinal plants and bioactive compounds on 4-HNE-induced disturbances, but strong evidence is needed that these plants and compounds serve as potent agents in the prevention and treatment of disorders driven by 4-HNE. Therefore, this review highlights the pharmacological basis of these medicinal plants and bioactive compounds to combat 4-HNE-induced deleterious effects in oxidative stress-related disorders, such as neurotoxicity and neurological disorder, eye damage, cardiovascular injury, liver injury, and energy metabolism disorder. In addition, this review briefly discusses with special attention to the strategies for developing potential therapies by future applications of these medicinal plants and bioactive compounds, which will help biological and pharmacological scientists to explore the new vistas of medicinal plants in combating 4-HNE-induced deleterious effects.

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Korean Red Ginseng attenuates ethanol-induced steatosis and oxidative stress via AMPK/Sirt1 activation

Cited by 60 publications

References 36 publications

Natural compounds in the chemoprevention of alcoholic liver disease

Natural compounds in the chemoprevention of alcoholic liver disease

Animal Models of Alcoholic Liver Disease: Pathogenesis and Clinical Relevance

Can Medicinal Plants and Bioactive Compounds Combat Lipid Peroxidation Product 4-HNE-Induced Deleterious Effects?

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